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Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice
Abstract
To determine which proteinases are responsible for the lung destruction characteristic of pulmonary emphysema, macrophage elastase–deficient (MME −/− ) mice were subjected to cigarette smoke. In contrast to wild-type mice, MME − / − mice did not have increased numbers of macrophages in their lungs and did not develop emphysema in response to long-term exposure to cigarette smoke. Smoke-exposed MME − / − mice that received monthly intratracheal instillations of monocyte chemoattractant protein–1 showed accumulation of alveolar macrophages but did not develop air space enlargement. Thus, macrophage elastase is probably sufficient for the development of emphysema that results from chronic inhalation of cigarette smoke.
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Cited by
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How Matrix Metalloproteinases Regulate Cell Behavior
Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959
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Metadata
- Authors
- Hautamaki, R. D., Kobayashi, D. K., Senior, R. M., & Shapiro, S. D.
- Venue
- Science
- Published
- 1997-09-26
- Volume
- 277
- Issue
- 5334
- Pages
- 2002-2004
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2099969611
- Cited by
- 1,469
- References
- 0
- FWCI
- 34.95
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hautamaki, R. D., Kobayashi, D. K., Senior, R. M., & Shapiro, S. D. (1997). Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice. Science. https://doi.org/10.1126/science.277.5334.2002
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