The DOI matches its Crossref record; 41 of the 41 references it cites were found in a registry or an index.
Mediation of Neuronal Apoptosis by Enhancement of Outward Potassium Current
Abstract
Apoptosis of mouse neocortical neurons induced by serum deprivation or by staurosporine was associated with an early enhancement of delayed rectifier ( I K ) current and loss of total intracellular K + . This I K augmentation was not seen in neurons undergoing excitotoxic necrosis or in older neurons resistant to staurosporine-induced apoptosis. Attenuating outward K + current with tetraethylammonium or elevated extracellular K + , but not blockers of Ca 2+ , Cl − , or other K + channels, reduced apoptosis, even if associated increases in intracellular Ca 2+ concentration were prevented. Furthermore, exposure to the K + ionophore valinomycin or the K + -channel opener cromakalim induced apoptosis. Enhanced K + efflux may mediate certain forms of neuronal apoptosis.
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Cites
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Cited by
Bonnet, S., Archer, S. L., Allalunis-Turner, J., Haromy, A., Beaulieu, C., Thompson, R., Lee, C. T., Lopaschuk, G. D., Puttagunta, L., Bonnet, S., et al. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.020 · Cited by 1,530
Physiology of cell volume regulation in vertebrates
Hoffmann, E. K., Lambert, I. H., & Pedersen, S. F. (2009) · Physiological Reviews · doi:10.1152/physrev.00037.2007 · Cited by 1,441
Mitochondria and neuronal survival
Nicholls, D. G., & Budd, S. L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.1.315 · Cited by 1,243
The changing landscape of ischaemic brain injury mechanisms
Lee, J.-M., Zipfel, G. J., & Choi, D. W. (1999) · Nature · doi:10.1038/399a007 · Cited by 1,102
Self-citationMolecular Background of Leak K+Currents: Two-Pore Domain Potassium Channels
Enyedi, P., & Czirják, G. (2010) · Physiological Reviews · doi:10.1152/physrev.00029.2009 · Cited by 868
Metadata
- Authors
- Yu, S. P., Yeh, C.-H., Sensi, S. L., Gwag, B. J., Canzoniero, L. M. T., Farhangrazi, Z. S., Ying, H. S., Tian, M., Dugan, L. L., & Choi, D. W.
- Venue
- Science
- Published
- 1997-10-03
- Volume
- 278
- Issue
- 5335
- Pages
- 114-117
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2082490296
- Cited by
- 578
- References
- 41
- FWCI
- 9.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Yu, S. P., Yeh, C.-H., Sensi, S. L., Gwag, B. J., Canzoniero, L. M. T., Farhangrazi, Z. S., Ying, H. S., Tian, M., Dugan, L. L., & Choi, D. W. (1997). Mediation of Neuronal Apoptosis by Enhancement of Outward Potassium Current. Science. https://doi.org/10.1126/science.278.5335.114
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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