Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell · doi:10.1016/0092-8674(94)90380-8 · Cited by 3,188

The stress-activated protein kinase subfamily of c-Jun kinases

Kyriakis, J. M., Banerjee, P. T., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., & Woodgett, J. R. (1994) · Nature · doi:10.1038/369156a0 · Cited by 2,601

Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine

Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7420 · Cited by 2,244

The mechanism of action of cyclosporin A and FK506

Schreiber, S. L., & Crabtree, G. R. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90111-j · Cited by 2,127

Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways

Whitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543

Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway

Gupta, S., Campbell, D., Dérijard, B., & Davis, R. J. (1995) · Science · doi:10.1126/science.7824938 · Cited by 1,433

Selective interaction of JNK protein kinase isoforms with transcription factors.

Gupta, S., Barrett, T., Whitmarsh, A. J., Cavanagh, J., Sluss, H. K., Dérijard, B., & Davis, R. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00636.x · Cited by 1,341

JNK is involved in signal integration during costimulation of T lymphocytes

Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M., & Ben‐Neriah, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90056-6 · Cited by 907

Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3

Beals, C. R., Sheridan, C. M., Turck, C. W., Gardner, P. I., & Crabtree, G. R. (1997) · Science · doi:10.1126/science.275.5308.1930 · Cited by 759

T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS

Cantrell, D. A. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.259 · Cited by 673

Nuclear factor of activated T (NFAT) cells activity within CD4+ T cells is influenced by activation status and tissue localisation

Harris, N. L., Watt, V., MacLenachan, S., Diehl, S. A., Marsland, B. J., Rincón, M., & Gros, G. S. L. (2005) · Microbes and Infection · doi:10.1016/j.micinf.2005.06.020 · Cited by 3

Signal Transduction to the Nucleus by MAP Kinase

Davis, R. J. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-218-0_9 · Cited by 3

Enzyme-Linked Immunosorbent Assay for the Measurement of JNK Activity in Cell Extracts

Tamaskovic, R., Forrer, P., & Jaussi, R. (1999) · Biological Chemistry · doi:10.1515/bc.1999.072 · Cited by 3

FOXO Transcription Factors

Brunet, A., Tran, H. G., & Greenberg, M. E. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00250-3 · Cited by 2

Genkwanin blocks the interaction between phosphorylated JNK and NFATc1 to promote osteogenic differentiation and collagen Ⅰ α1 production

Hao, Y., Chen, Y.-Y., Han, X., Wang, X., Wu, F.-P., Wen, C.-L., Chen, T.-Q., Tan, S., Zheng, D.-D., Hong, Y., et al. (2025) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2025.177687 · Cited by 2

NFAT-Dependent Gene Expression in the Nervous System: A Critical Mediator of Neurotrophin-Induced Plasticity

Groth, R. D., & Mermelstein, P. G. (2007) · Springer eBooks · doi:10.1007/978-0-387-73609-9_10 · Cited by 2

Direct effects of the angiotensin‐converting enzyme inhibitor ramiprilat on adult rat ventricular cardiomyocytes

Helmig, S., Schuckenböhmer, P., Heger, J., Euler, G., Piper, H. M., & Schlüter, K. ‐. (2007) · Acta Physiologica · doi:10.1111/j.1748-1716.2007.01738.x · Cited by 2

Mechanosensitive phosphorylation of NFATC4 at S213/S217 drives fibroblast-to-myofibroblast transition and fibrosis

Kadri, S., Mattner, L. F., Zeng, Z., Prakki, S. R. S., Verma, A. K., Cetin, U., Mayr, C. H., Ansari, M., Wei, X., Asgharpour, S., et al. (2026) · Journal of Clinical Investigation · doi:10.1172/jci195121 · Cited by 1

Evolution of mechanisms of Ca2+-signaling. Role of Ca2+ in regulation of fundamental cell functions

Шемарова, И. В., & Нестеров, В. П. (2008) · Journal of Evolutionary Biochemistry and Physiology · doi:10.1134/s0022093008040017 · Cited by 1

The NFAT Family: Structure, Regulation, and Biological Functions

Macián, F., & Rao, A. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50650-1 · Cited by 1

Fibrotic Signaling in Cardiomyopathies

Ravi, S., Willis, M. S., & Schisler, J. C. (2018) · Molecular and translational medicine · doi:10.1007/978-3-319-98143-7_10 · Cited by 1

Calcineurin-Targeted Inhibition of Immune Reactivity

Kung, L., & Halloran, P. F. (2001) · Springer eBooks · doi:10.1007/978-94-010-0765-8_1 · Cited by 1

Signaling pathways in myocyte hypertrophy : role of GATA4, mitogen-activated protein kinases and protein kinase C

Kerkelä, R. (2003) · Cited by 1

[The effect of ascorbic acid in preservation solutions on the antioxidative potential of blood plasma during liver transplantation in miniature swine].

Popov, I. N., Gäbel, W., Lohse, W., Lewin, G., Richter, E., & von Baehr, R. (1989) · PubMed · Cited by 1

Osteoclast Signal Transduction Pathways: The RANKL/RANK System

Yao, Z., & Boyce, B. F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.62203-1 · Cited by 1

BLyS/BR3 Receptor Signaling in the Biology and Pathophysiology of Aggressive B-Cell Lymphomas

Fu, L., Pham, L. V., Lin-Lee, Y.-C., Tamayo, A. T., & Ford, R. J. (2009) · Humana Press eBooks · doi:10.1007/978-1-60327-013-7_11

Novel insights into the calcineurin/NFAT pathway in cardiac hypertrophy

van Rooij, E. (2004) · doi:10.26481/dis.20041209er

Identificación de nuevos mecanismos moleculares del inmunosupresor FK506 en Saccharomyces cervisiae

Hernández, C. J. R. (2006) · doi:10.4995/thesis/10251/1849

Regulación transcripcional dependiente de calcio en el sistema nervioso

Naranjo, J. R., & Gómez‐Villafuertes, R. (2009) · Dialnet (Universidad de la Rioja)

IDENTIFICACIÓN DE PROTEÍNAS QUE INTERACCIONAN CON CypA, CypB Y FKBP12 Y SU IMPLICACIÓN EN LA TOXICIDAD RENAL PRODUCIDA POR LOS INMUNOSUPRESORES CsA Y FK506

Rodríguez, G. S. (2008) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Gene Expression in Vascular Smooth Muscle

Rose, P. (2007) · ScholarWorks -A service of University of Vermont Libraries (University of Vermont)

Diabetic Vascular Complications & Inflammation - role of NFAT and TNFalpha

Öhman, J. N. (2009) · Lund University Publications (Lund University)

Wnt-5a signaling in breast cancer metastasis

Säfholm, A. (2007) · Lund University Publications (Lund University)

Discrimination of JNK3 bound small molecules by saturation transfer difference NMR experiments

Lim, J.-S., & Ahn, H. (2012) · Journal of the Korean Magnetic Resonance Society · doi:10.6564/jkmrs.2012.16.1.067

Regulatory mechanisms of the Ca2+-dependent transcription factor NFAT in sensory neurons

Kim, M. S. (2009) · doi:10.17077/etd.2147nhlk

Regulation of ATF3 expression in cardiomyocytes

Giraldo Ramirez, D. A. (2008) · Spiral (Imperial College London) · doi:10.25560/1300

The role of NFAT proteins in Rag and Nfatc1a Gene Regulation in Murine Thymus

Yang, S. (2007) · Online Publication Service of Würzburg University (Würzburg University)

Development and application of genus-specific peptide arrays for kinome analysis

Arsenault, R. J. (2011) · HARVEST (University of Saskatchewan)

SIGNALING PATHWAYS IN MYOCYTE HYPERTROPHY

Oulu, B. (2003)

PROTEIN KINASE Cµ IN TC ELL ACTIVATION

Isakov, N., & Altman, A. (2002)

The role of nuclear factors of activated T-cells (NFAT) in neuronal death.

Habas, A. (2004) · doi:10.18297/etd/555

NFAT and MEF2, Two Families of Calcium-dependent Transcription Regulators

Liu, J. O., Chen, L., Pan, F., & Stroud, J. C. (2007) · Springer eBooks · doi:10.1007/978-0-387-40049-5_17

Regulation of NFAT5 by signaling pathways involved in osmotic stress responses and cell growth

Armisen, B. M. (2008) · Repositori digital de la UPF (Universitat Pompeu Fabra)

Mechanisms of Stress Response Signaling and Recovery in the Liver of Young versus Aged Mice: The p38 MAPK and SOCS Families of Regulatory Proteins

Papaconstantinou, J. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50705-1

Calcineurin-NFAT Signaling in Cardiac Hypertrophy: In Sickness and In Health?

Wilkins, B. J. (2004) · OhioLink ETD Center (Ohio Library and Information Network)

The role of JIP-1 in JNK signalling during stress and apoptosis

Vaishnav, M. (2002) · Figshare

Protease-activated receptor (PAR)-1 and PAR-2 protect rat astrocytes from apoptotic cell death via differentially regulating JNK isoform-specific release of the chemokine GRO/CINC-1 - two novel protective pathways in brain

Wang, Y. (2007) · Digitalen Hochschulbibliothek Sachsen-Anhalt (Universitäts- und Landesbibliothek Sachsen-Anhalt) · doi:10.25673/4753

Caractérisation du rôle de la protéine kinase MEK1 dans les voies de transduction des MAP kinases

Chetoui, N. (2005) · Corpus Université Laval (Université Laval)

Transcriptional Control through Regulated Nuclear Transport

Ho, S. N. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50651-3

Phenylephrine preconditioning of isolated ventricular myocytes involves modulation of KATP channels through activation of survival kinases

Turrell, H. E. (2009) · Leicester Research Archive (University of Leicester)

FOXO Transcription Factors: Key Targets of the PI3K-Akt Pathway That Regulate Cell Proliferation, Survival, and Organismal Aging

Brunet, A., Tran, H. G., & Greenberg, M. E. (2003) · Elsevier eBooks · doi:10.1016/b978-012124546-7/50645-8

Redox regulation of protein serine/threonine phosphatase calcineurin

Namgaladze, D. (2002) · KOPS (University of Konstanz)

Functions of stress-activated MAP kinases in the immune response

Rincón, M., & Davis, R. J. (2007) · Springer eBooks · doi:10.1007/4735_2007_0253

Additional file 7 of Global DNA methylation pattern involved in the modulation of differentiation potential of adipogenic and myogenic precursors in skeletal muscle of pigs

Zhang, X., Sun, W., He, L., Wang, L., Qiu, K., & Yin, J. (2020) · Figshare · doi:10.6084/m9.figshare.13468001

Additional file 2 of Global DNA methylation pattern involved in the modulation of differentiation potential of adipogenic and myogenic precursors in skeletal muscle of pigs

Zhang, X., Sun, W., He, L., Wang, L., Qiu, K., & Yin, J. (2020) · Figshare · doi:10.6084/m9.figshare.13467989

Additional file 6 of Global DNA methylation pattern involved in the modulation of differentiation potential of adipogenic and myogenic precursors in skeletal muscle of pigs

Zhang, X., Sun, W., He, L., Wang, L., Qiu, K., & 尹靖东 (2020) · Figshare · doi:10.6084/m9.figshare.13467999

Additional file 1 of Global DNA methylation pattern involved in the modulation of differentiation potential of adipogenic and myogenic precursors in skeletal muscle of pigs

Zhang, X., Sun, W., He, L., Wang, L., Qiu, K., & Yin, J. (2020) · Figshare · doi:10.6084/m9.figshare.13467985

Additional file 3 of Global DNA methylation pattern involved in the modulation of differentiation potential of adipogenic and myogenic precursors in skeletal muscle of pigs

Zhang, X., Sun, W., He, L., Wang, L., Qiu, K., & 尹靖东 (2020) · Figshare · doi:10.6084/m9.figshare.13467991

Additional file 4 of Global DNA methylation pattern involved in the modulation of differentiation potential of adipogenic and myogenic precursors in skeletal muscle of pigs

Zhang, X., Sun, W., He, L., Wang, L., Qiu, K., & 尹靖东 (2020) · Figshare · doi:10.6084/m9.figshare.13467995

Additional file 5 of Global DNA methylation pattern involved in the modulation of differentiation potential of adipogenic and myogenic precursors in skeletal muscle of pigs

Zhang, X., Sun, W., He, L., Wang, L., Qiu, K., & 尹靖东 (2020) · Figshare · doi:10.6084/m9.figshare.13467997

Rôle du canal TRPM4 dans l'hypertrophie cardiaque : utilisation d'un modèle d'entraînement.

Gueffier, M. (2015) · doi:10.70675/eb7eb9d2z097fz4aa6z8f36zf94885673bd5

Contribution de la protéine O-fucosyltransférase 1( POFUT1) à la différenciation myogénique et à la tumorigenèse colorectale

Chabanais, J. (2019) · theses.fr (ABES) · doi:10.70675/e92b8968z3dd2z4735z8091z1f5f9a03059e

Etude des effecteurs de la voie Ca2+/Calmoduline dans les leucémies aiguës lymphoblastiques T

Catherinet, C. (2017) · theses.fr (ABES) · doi:10.70675/aa90c6a6z8815z4b8bz81ccz3038ffc2614d

Regulation of NFATc3 stability by SUMO and E3 ubiquitin-ligases Trim39 and Trim17

Basu-Shrivastava, M. (2020) · theses.fr (ABES) · doi:10.70675/0aa33054zc607z413dz8aedz05ed052d5438 · Cited by 1

BindingDB Entry 50034185: Synthesis and SAR of 2-phenoxypyridines as novel c-Jun N-terminal kinase inhibitors.

BindingDB (2012) · UC San Diego · doi:10.7270/q2v69k0w

BindingDB Entry 50042910: Design and synthesis of 1-aryl-5-anilinoindazoles as c-Jun N-terminal kinase inhibitors.

BindingDB (2014) · UC San Diego · doi:10.7270/q21837wc

The regulaton and function of nuclear factor of activated T-cells in neurons

Ulrich, J. D. (2011) · doi:10.17077/etd.7apq8oau

c-Jun NH 2 -Terminal Kinase Inhibits Targeting of the Protein Phosphatase Calcineurin to NFATc1

Chow, C.-W., Dong, C., Flavell, R. A., & Davis, R. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5227-5234.2000 · Cited by 140

Role of kinases and the phosphatase calcineurin in the nuclear shuttling of transcription factor NF-AT4

Shibasaki, F., Price, E. R., Milan, D. J., & McKeon, F. (1996) · Nature · doi:10.1038/382370a0 · Cited by 487

c-Jun N-terminal Kinase (JNK) Positively Regulates NFATc2 Transactivation through Phosphorylation within the N-terminal Regulatory Domain

Ortega‐Pérez, I., Cano, E., Were, F., Villar, M., Vázquez, J., & Redondo, J. M. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501898200 · Cited by 79

Dynamic equilibrium between calcineurin and kinase activities regulates the phosphorylation state and localization of the nuclear factor of activated T-cells

Scott, J. E., Ruff, V. A., & Leach, K. L. (1997) · Biochemical Journal · doi:10.1042/bj3240597 · Cited by 11

A Role for the p38 MAP Kinase Pathway in the Nuclear Shuttling of NFATp

Arco, P. G., Martı́nez-Martı́nez, S., Maldonado, J. L., Ortega‐Pérez, I., & Redondo, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13872 · Cited by 159