Cited by 357Signaling Pathways in DiseaseProtein Kinase Regulation and GTPase SignalingGenomics and Chromatin Dynamics

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

Chow, Chi-Wing, Rincón, Mercedes, Cavanagh, Julie, Dickens, Martin, Davis, Roger J.·1997·Science

Open this paper in CoChat — free account

Abstract

The nuclear factor of activated T cells (NFAT) group of transcription factors is retained in the cytoplasm of quiescent cells. NFAT activation is mediated in part by induced nuclear import. This process requires calcium-dependent dephosphorylation of NFAT caused by the phosphatase calcineurin. The c-Jun amino-terminal kinase (JNK) phosphorylates NFAT4 on two sites. Mutational removal of the JNK phosphorylation sites caused constitutive nuclear localization of NFAT4. In contrast, JNK activation in calcineurin-stimulated cells caused nuclear exclusion of NFAT4. These findings show that the nuclear accumulation of NFAT4 promoted by calcineurin is opposed by the JNK signal transduction pathway.

Integrity signals

Registry

Crossref · 10.1126/science.278.5343.1638

Cites

24 of 24 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain
Dérijard, B., Hibi, M., Wu, I.-H., Barrett, T., Su, B., Deng, T., Karin, M., & Davis, R. J. (1994) · Cell · doi:10.1016/0092-8674(94)90380-8 · Cited by 3,188
Self-citation
The stress-activated protein kinase subfamily of c-Jun kinases
Kyriakis, J. M., Banerjee, P. T., Nikolakaki, E., Dai, T., Rubie, E. A., Ahmad, M. F., Avruch, J., & Woodgett, J. R. (1994) · Nature · doi:10.1038/369156a0 · Cited by 2,601
Pro-inflammatory Cytokines and Environmental Stress Cause p38 Mitogen-activated Protein Kinase Activation by Dual Phosphorylation on Tyrosine and Threonine
Raingeaud, J., Gupta, S., Rogers, J. S., Dickens, M., Han, J., Ulevitch, R. J., & Davis, R. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.13.7420 · Cited by 2,244
Self-citation
The mechanism of action of cyclosporin A and FK506
Schreiber, S. L., & Crabtree, G. R. (1992) · Immunology Today · doi:10.1016/0167-5699(92)90111-j · Cited by 2,127
Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways
Whitmarsh, A. J., & Davis, R. J. (1996) · Journal of Molecular Medicine · doi:10.1007/s001090050063 · Cited by 1,543
Self-citation
Transcription Factor ATF2 Regulation by the JNK Signal Transduction Pathway
Gupta, S., Campbell, D., Dérijard, B., & Davis, R. J. (1995) · Science · doi:10.1126/science.7824938 · Cited by 1,433
Self-citation
Selective interaction of JNK protein kinase isoforms with transcription factors.
Gupta, S., Barrett, T., Whitmarsh, A. J., Cavanagh, J., Sluss, H. K., Dérijard, B., & Davis, R. J. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00636.x · Cited by 1,341
Self-citation
JNK is involved in signal integration during costimulation of T lymphocytes
Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M., & Ben‐Neriah, Y. (1994) · Cell · doi:10.1016/0092-8674(94)90056-6 · Cited by 907
Nuclear Export of NF-ATc Enhanced by Glycogen Synthase Kinase-3
Beals, C. R., Sheridan, C. M., Turck, C. W., Gardner, P. I., & Crabtree, G. R. (1997) · Science · doi:10.1126/science.275.5308.1930 · Cited by 759
T CELL ANTIGEN RECEPTOR SIGNAL TRANSDUCTION PATHWAYS
Cantrell, D. A. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.259 · Cited by 673

Show all 24 references

Research works printed but not linked: 2

Dickens M., et al., ibid. 277, 693 (1997)].
Rapp U. R., Troppmair J., Beck T., Birrer M. J., Oncogene 9, 3493 (1994);

Sorted by citations

Free radicals, metals and antioxidants in oxidative stress-induced cancer
Valko, M., Rhodes, C. J., Moncol, J., Izakovic, M., & Mazur, M. (2006) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2005.12.009 · Cited by 6,680
Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions*
Pearson, G. W., Robinson, F. L., Gibson, T. B., Xu, B.-E., Karandikar, M. S., Berman, K. S., & Cobb, M. H. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.2.0428 · Cited by 4,111
Mammalian Mitogen-Activated Protein Kinase Signal Transduction Pathways Activated by Stress and Inflammation
Kyriakis, J. M., & Avruch, J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.807 · Cited by 3,400
Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human
Widmann, C., Gibson, S. B., Jarpe, M. B., & Johnson, G. L. (1999) · Physiological Reviews · doi:10.1152/physrev.1999.79.1.143 · Cited by 2,707
Transcriptional regulation by calcium, calcineurin, and NFAT
Hogan, P. G., Chen, L., Nardone, J., & Rao, A. (2003) · Genes & Development · doi:10.1101/gad.1102703 · Cited by 1,991
Mitogen-Activated Protein Kinases: Specific Messages from Ubiquitous Messengers
Schaeffer, H. J., & Weber, M. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.4.2435 · Cited by 1,600
NFAT proteins: key regulators of T-cell development and function
Macián, F. (2005) · Nature reviews. Immunology · doi:10.1038/nri1632 · Cited by 1,624
Signal transduction by the c-Jun N-terminal kinase (JNK) — from inflammation to development
Ip, Y. T., & Davis, R. J. (1998) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(98)80143-9 · Cited by 1,538
Self-citation
Mammalian MAPK Signal Transduction Pathways Activated by Stress and Inflammation: A 10-Year Update
Kyriakis, J. M., & Avruch, J. (2012) · Physiological Reviews · doi:10.1152/physrev.00028.2011 · Cited by 1,529
The Jnk1 and Jnk2 Protein Kinases Are Required for Regional Specific Apoptosis during Early Brain Development
Kuan, C.-Y., Yang, D. D., Roy, D. R. S., Davis, R. J., RAKIC, P. T., & Flavell, R. A. (1999) · Neuron · doi:10.1016/s0896-6273(00)80727-8 · Cited by 889
Self-citation
Partners in transcription: NFAT and AP-1
Macián, F., López‐Rodríguez, C., & Rao, A. (2001) · Oncogene · doi:10.1038/sj.onc.1204386 · Cited by 766
Generic Signals and Specific Outcomes
Crabtree, G. R. (1999) · Cell · doi:10.1016/s0092-8674(00)80571-1 · Cited by 730
Mitogen-activated protein kinases: new signaling pathways functioning in cellular responses to environmental stress
Cowan, K. J., & Storey, K. B. (2003) · Journal of Experimental Biology · doi:10.1242/jeb.00220 · Cited by 594
Defective T Cell Differentiation in the Absence of Jnk1
Dong, C., Yang, D. D., Wysk, M., Whitmarsh, A. J., Davis, R. J., & Flavell, R. A. (1998) · Science · doi:10.1126/science.282.5396.2092 · Cited by 579
Self-citation
FOXO transcription factors
Carter, M. E., & Brunet, A. (2007) · Current Biology · doi:10.1016/j.cub.2007.01.008 · Cited by 588
Uses for JNK: the Many and Varied Substrates of the c-Jun N-Terminal Kinases
Bogoyevitch, M. A., & Kobe, B. (2006) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00025-06 · Cited by 584
Regulation of NFATc1 in Osteoclast Differentiation
Kim, J. H., & Kim, N. (2014) · Journal of Bone Metabolism · doi:10.11005/jbm.2014.21.4.233 · Cited by 570
“Several kinases such as glycogen synthase kinase 3 (GSK3), casein kinase 1 (CK1), p38, and JNK phosphorylate the various serine-rich motifs in NFAT proteins, thereby preventing translocation into the nucleus or promoting nuclear export of NFAT proteins.[59-63] A recent study has reported that the ectopic expression of…”
Background
JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships
Zeke, A., Misheva, M., Reményi, A., & Bogoyevitch, M. A. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00043-14 · Cited by 552
L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons
Graef, I. A., Mermelstein, P. G., Stankunas, K., Neilson, J. R., Deisseroth, K. A., Tsien, R. W., & Crabtree, G. R. (1999) · Nature · doi:10.1038/44378 · Cited by 514
Calcineurin?NFAT signaling regulates the cardiac hypertrophic response in coordination with the MAPKs
Molkentin, J. D. (2004) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.01.021 · Cited by 504
Transcriptional regulation by the MAP kinase signaling cascades
Yang, S., Sharrocks, A. D., & Whitmarsh, A. J. (2003) · Gene · doi:10.1016/s0378-1119(03)00816-3 · Cited by 498
Concerted Dephosphorylation of the Transcription Factor NFAT1 Induces a Conformational Switch that Regulates Transcriptional Activity
Okamura, H., Aramburu, J. F., García‐Rodríguez, C., Viola, J. P. B., Raghavan, A., Tahiliani, M., Zhang, X., Qin, J., Hogan, P. G., & Rao, A. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00053-8 · Cited by 481
Activated glycogen synthase-3β suppresses cardiac hypertrophy in vivo
Antos, C. L., McKinsey, T. A., Frey, N., Kutschke, W. J., McAnally, J., Shelton, J. M., Richardson, J. A., Hill, J. A., & Olson, E. N. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.231619298 · Cited by 476
Differentiation of CD4+ T Cells to Th1 Cells Requires MAP Kinase JNK2
Yang, D. D., Conze, D. B., Whitmarsh, A. J., Barrett, T., Davis, R. J., Rincón, M., & Flavell, R. A. (1998) · Immunity · doi:10.1016/s1074-7613(00)80640-8 · Cited by 453
Self-citation
Calcium–calcineurin signaling in the regulation of cardiac hypertrophy
Wilkins, B. J., & Molkentin, J. D. (2004) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2004.07.121 · Cited by 447
Calcium, Calcineurin, and the Control of Transcription
Crabtree, G. R. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.r000024200 · Cited by 440
MAP kinases and the control of nuclear events
Turjanski, A. G., Vaque, J. P., & Gutkind, J. S. (2007) · Oncogene · doi:10.1038/sj.onc.1210415 · Cited by 439
Akt Blocks Breast Cancer Cell Motility and Invasion through the Transcription Factor NFAT
Yoeli-Lerner, M., Yiu, G. K., Rabinovitz, I., Erhardt, P., Jauliac, S., & Toker, A. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.10.033 · Cited by 407
Protein Kinase Cθ in T Cell Activation
Isakov, N., & Altman, A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064807 · Cited by 369
Involvement of c-Jun N-terminal Kinase in Oxidative Stress-mediated Suppression of Insulin Gene Expression
Kaneto, H., Xu, G., FUJII, N. L., Kim, S., Bonner‐Weir, S., & Weir, G. C. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202066200 · Cited by 349
Regulation of transcription factor function by phosphorylation
Whitmarsh, A. J., & Davis, R. J. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000757 · Cited by 345
Self-citation
Intramolecular Masking of Nuclear Import Signal on NF-AT4 by Casein Kinase I and MEKK1
Zhu, J., Shibasaki, F., Price, R., Guillemot, J.-C., Yano, T., Dötsch, V., Wagner, G., Ferrara, P., & McKeon, F. (1998) · Cell · doi:10.1016/s0092-8674(00)81445-2 · Cited by 307
A conserved family of calcineurin regulatorsPreprint
Kingsbury, T. J., & Cunningham, K. W. (2000) · Genes & Development · doi:10.1101/gad.14.13.1595 · Cited by 305
Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38
Harper, S. J., & LoGrasso, P. V. (2001) · Cellular Signalling · doi:10.1016/s0898-6568(01)00148-6 · Cited by 304
Differential targeting of MAP kinases to the ETS‐domain transcription factor Elk‐1
Yang, S., Whitmarsh, A. J., Davis, R. J., & Sharrocks, A. D. (1998) · The EMBO Journal · doi:10.1093/emboj/17.6.1740 · Cited by 299
Self-citation
Calcineurin: From structure to function
Aramburu, J. F., Rao, A., & Klee, C. B. (2001) · Current topics in cellular regulation · doi:10.1016/s0070-2137(01)80011-x · Cited by 299
Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development
Schulz, R. A., & Yutzey, K. E. (2003) · Developmental Biology · doi:10.1016/j.ydbio.2003.10.008 · Cited by 302
Manipulating Immune Responses with Immunosuppressive Agents that Target NFAT
Kiani, A., Rao, A., & Aramburu, J. F. (2000) · Immunity · doi:10.1016/s1074-7613(00)80188-0 · Cited by 281
Interaction of a mitogen-activated protein kinase signaling module with the neuronal protein JIP3
Kelkar, N., Gupta, S., Dickens, M., & Davis, R. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.3.1030-1043.2000 · Cited by 281
Self-citation
Targeting the JNK MAPK cascade for inhibition: basic science and therapeutic potential
Bogoyevitch, M. A., Boehm, I., Oakley, A. J., Ketterman, A. J., & Barr, R. K. (2003) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2003.11.016 · Cited by 270
The Transcription Factor NFAT4 Is Involved in the Generation and Survival of T Cells
Oukka, M., Ho, I., de la Brousse, F. C., Hoey, T., Grusby, M. J., & Glimcher, L. H. (1998) · Immunity · doi:10.1016/s1074-7613(00)80612-3 · Cited by 266
Regulation of the immune response by stress‐activated protein kinases
Rincón, M., & Davis, R. J. (2009) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00744.x · Cited by 272
Self-citation
Regulation of Mitogen-Activated Protein Kinase Signaling Networks by G Protein-Coupled Receptors
Gutkind, J. S. (2000) · Science Signaling · doi:10.1126/stke.2000.40.re1 · Cited by 277
MAPK signaling pathways in the regulation of hematopoiesis
Geest, C. R., & Coffer, P. J. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0209097 · Cited by 267
NFAT functions as a working memory of Ca2+ signals in decoding Ca2+ oscillation
Tomida, T., Hirose, K., Takizawa, A., Shibasaki, F., & Iino, M. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg381 · Cited by 255
Regeneration in the metazoans: why does it happen?
Alvarado, A. S. (2000) · BioEssays · doi:10.1002/(sici)1521-1878(200006)22:6 · Cited by 342
Interleukin-7: physiological roles and mechanisms of action
Hofmeister, R., Khaled, A. R., Benbernou, N., Rajnavölgyi, É., Muegge, K., & Durum, S. K. (1999) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(98)00025-2 · Cited by 243
Redefining the roles of p38 and JNK signaling in cardiac hypertrophy: dichotomy between cultured myocytes and animal models
Liang, Q. (2003) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2003.10.001 · Cited by 239
Calcineurin as a Multifunctional Regulator
Shibasaki, F., Hallin, U., & Uchino, H. (2002) · The Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a003063 · Cited by 230
TRANSCRIPTIONAL AND POST-TRANSCRIPTIONAL CONTROL OF GENE EXPRESSION IN INFLAMMATION
Kracht, M., & Saklatvala, J. (2002) · Cytokine · doi:10.1006/cyto.2002.0895 · Cited by 229
Activation and Cellular Localization of the Cyclosporine A-sensitive Transcription Factor NF-AT in Skeletal Muscle Cells
Abbott, K. L., Friday, B. B., Thaloor, D., Murphy, T. J., & Pavlath, G. K. (1998) · Molecular Biology of the Cell · doi:10.1091/mbc.9.10.2905 · Cited by 226
Molecular determinants that mediate selective activation of p38 MAP kinase isoforms
Enslen, H., Brancho, D. M., & Davis, R. J. (2000) · The EMBO Journal · doi:10.1093/emboj/19.6.1301 · Cited by 222
Self-citation
C-Jun Nh2-Terminal Kinase (Jnk)1 and Jnk2 Have Similar and Stage-Dependent Roles in Regulating T Cell Apoptosis and Proliferation
Sabapathy, K., Kallunki, T., David, J., Graef, I. A., Karin, M., & Wagner, E. F. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.3.317 · Cited by 220
Alteration in temporal kinetics of Ca2+ signaling and control of growth and proliferation
Lipskaia, L., & Lompré, A. (2004) · Biology of the Cell · doi:10.1016/j.biolcel.2003.11.001 · Cited by 224
NFAT signaling in vertebrate development
Graef, I. A., Chen, F., & Crabtree, G. R. (2001) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(00)00225-2 · Cited by 215
The role of NF-AT transcription factors in T cell activation and differentiation11We dedicate this review to Prof. Dr. Rigomar Rieger (Gatersleben), a great scientist and man, on the occasion of his 70th birthday. One of us (E.S.) had the pleasure of working in his department.
Serfling, E., Berberich‐Siebelt, F., Chuvpilo, S. A., Jankevics, E., Klein‐Hessling, S., Twardzik, T., & Avots, A. (2000) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/s0167-4889(00)00082-3 · Cited by 213
Advances in Carcinogenic Metal Toxicity and Potential Molecular Markers
Koedrith, P., & Seo, Y. R. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12129576 · Cited by 209
Carcinogenic effect of nickel compounds
Lu, H., Shi, X., Costa, M., & Huang, C. (2005) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-005-8215-2 · Cited by 210
JNK pathway: diseases and therapeutic potential
Cui, J., Zhang, M., Zhang, Y., & Xu, Z. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00579.x · Cited by 202
Nuclear Import and Export of Viruses and Virus Genomes
Whittaker, G. R., & Helenius, A. (1998) · Virology · doi:10.1006/viro.1998.9165 · Cited by 200
Crystal structure of JNK3: a kinase implicated in neuronal apoptosis
Xie, X., Gu, Y., Fox, T., Coll, J. T., Fleming, M. A., Markland, W., Caron, P. R., Wilson, K. P., & Su, M. S.-S. (1998) · Structure · doi:10.1016/s0969-2126(98)00100-2 · Cited by 198
Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation
Itoh, M., Adachi, M., Yasui, H., Takekawa, M., Tanaka, H., & Imai, K. (2002) · Molecular Endocrinology · doi:10.1210/me.2002-0144 · Cited by 238
Requirement for Transcription Factor NFAT in Interleukin-2 Expression
Chow, C.-W., Rincón, M., & Davis, R. J. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.3.2300 · Cited by 198
Self-citation
c‐Jun N‐terminal kinases (JNK) antagonize cardiac growth through cross‐talk with calcineurin–NFAT signaling
Liang, Q., Bueno, O. F., Wilkins, B. J., Kuan, C.-Y., Xia, Y., & Molkentin, J. D. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg474 · Cited by 197
Signaling in Myocardial Hypertrophy
Sugden, P. H. (1999) · Circulation Research · doi:10.1161/01.res.84.6.633 · Cited by 196
Multiple transcription factor families regulate axon growth and regeneration
Moore, D. L., & Goldberg, J. L. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20934 · Cited by 195
NFAT signaling and the invention of vertebrates
Wu, H., Peisley, A., Graef, I. A., & Crabtree, G. R. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.04.006 · Cited by 196
Revisiting the Concept of Targeting NFAT to Control T Cell Immunity and Autoimmune Diseases
Lee, J.-U., Kim, L.-K., & Choi, J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02747 · Cited by 205
Increasingly complex: New players enter the Wnt signaling network
Pandur, P., Maurus, D., & Kühl, M. (2002) · BioEssays · doi:10.1002/bies.10164 · Cited by 188
Specificity of Linear Motifs That Bind to a Common Mitogen-Activated Protein Kinase Docking Groove
Garai, Á., Zeke, A., Gógl, G., Törő, I., Fördős, F., Blankenburg, H., Bárkai, T., Varga, J., Alexa, A., Emig, D., et al. (2012) · Science Signaling · doi:10.1126/scisignal.2003004 · Cited by 177
A Conserved Docking Motif for CK1 Binding Controls the Nuclear Localization of NFAT1
Okamura, H., García‐Rodríguez, C., Martinson, H. M., Qin, J., Virshup, D. M., & Rao, A. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.10.4184-4195.2004 · Cited by 195
Phosphorylation of NFATc4 by p38 Mitogen-Activated Protein Kinases
Yang, T. T. C., Xiong, Q., Enslen, H., Davis, R. J., & Chow, C.-W. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.11.3892-3904.2002 · Cited by 174
Self-citation
MAP kinases in inflammatory bowel disease
Coskun, M., Olsen, J., Seidelin, J. B., & Nielsen, O. H. (2010) · Clinica Chimica Acta · doi:10.1016/j.cca.2010.12.020 · Cited by 176
The NFAT-Related Protein NFATL1 (TonEBP/NFAT5) Is Induced Upon T Cell Activation in a Calcineurin-Dependent Manner
Trama, J. P., Lu, Q., Hawley, R. G., & Ho, S. N. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.9.4884 · Cited by 170
The JNK and P38 MAP kinase signaling pathways in T cell–mediated immune responses44This team of investigators has contributed extensively to the field of MAP kinase signal transduction in thymocyte and T cell differentiation.
Rincón, M., Flavell, R. A., & Davis, R. J. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(00)00219-7 · Cited by 167
Self-citation
Calcineurin and cardiac hypertrophy: Where have we been? Where are we going?
Wilkins, B. J., & Molkentin, J. D. (2002) · The Journal of Physiology · doi:10.1113/jphysiol.2002.017129 · Cited by 163
Glycogen Synthase Kinase-3 Inhibits the DNA Binding Activity of NFATc
Neal, J. W., & Clipstone, N. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m004888200 · Cited by 167
Regulation of Calcineurin by Growth Cone Calcium Waves Controls Neurite Extension
Lautermilch, N. J., & Spitzer, N. C. (2000) · Journal of Neuroscience · doi:10.1523/jneurosci.20-01-00315.2000 · Cited by 164
Constitutive NF-κB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomas
Fu, L., Lin-Lee, Y.-C., Pham, L. V., Tamayo, A. T., Yoshimura, L. C., & Ford, R. J. (2006) · Blood · doi:10.1182/blood-2005-10-4042 · Cited by 162
Direct and Indirect Interactions between Calcineurin-NFAT and MEK1-Extracellular Signal-Regulated Kinase 1/2 Signaling Pathways Regulate Cardiac Gene Expression and Cellular Growth
Sanna, B., Bueno, O. F., Dai, Y., Wilkins, B. J., & Molkentin, J. D. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.3.865-878.2005 · Cited by 162
Transcription Factors in Lymphocyte Development— T and B Cells Get Together
Glimcher, L. H., & Singh, H. (1999) · Cell · doi:10.1016/s0092-8674(00)80955-1 · Cited by 157
A Role for the p38 MAP Kinase Pathway in the Nuclear Shuttling of NFATp
Arco, P. G., Martı́nez-Martı́nez, S., Maldonado, J. L., Ortega‐Pérez, I., & Redondo, J. M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.18.13872 · Cited by 159
Crosstalk between mitogen-activated protein kinases and mitochondria in cardiac diseases: Therapeutic perspectives
Javadov, S. A., Jang, S., & Agostini, B. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.05.013 · Cited by 159
Glycogen Synthase Kinase 3β and Extracellular Signal-Regulated Kinase Inactivate Heat Shock Transcription Factor 1 by Facilitating the Disappearance of Transcriptionally Active Granules after Heat Shock
He, B., Meng, Y., & Mivechi, N. F. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.11.6624 · Cited by 157
Calcineurin-Crz1 Signaling in Lower Eukaryotes
Thewes, S. (2014) · Eukaryotic Cell · doi:10.1128/ec.00038-14 · Cited by 157
Osteoclast differentiation requires TAK1 and MKK6 for NFATc1 induction and NF-κB transactivation by RANKL
Huang, H., Ryu, J., Ha, J., Chang, E.-J., Kim, H. J., Kim, H.-M., Kitamura, T., Lee, Z. H., & Kim, H. (2006) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401882 · Cited by 156
P2X7 receptor activation induces CXCL2 production in microglia through NFAT and PKC/MAPK pathways
Shiratori, M., Tozaki‐Saitoh, H., Yoshitake, M., Tsuda, M., & Inoue, K. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06809.x · Cited by 153
Ca2+-Operated Transcriptional Networks: Molecular Mechanisms and In Vivo Models
Mellström, B., Savignac, M., Gómez‐Villafuertes, R., & Naranjo, J. R. (2008) · Physiological Reviews · doi:10.1152/physrev.00041.2005 · Cited by 160
Identification of Amino Acid Residues and Protein Kinases Involved in the Regulation of NFATc Subcellular Localization
Porter, C. M., Havens, M. A., & Clipstone, N. A. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.275.5.3543 · Cited by 151
Role of the JNK Pathway in Human Diseases
Sabapathy, K. (2012) · Progress in molecular biology and translational science · doi:10.1016/b978-0-12-396456-4.00013-4 · Cited by 149
The Function Role of GATA-3 in Th1 and Th2 Differentiation
Zhou, M., & Ouyang, W. (2003) · Immunologic Research · doi:10.1385/ir:28:1:25 · Cited by 153
Wnt-5a/Ca2+-Induced NFAT Activity Is Counteracted by Wnt-5a/Yes-Cdc42-Casein Kinase 1α Signaling in Human Mammary Epithelial Cells
Dejmek, J. S., Säfholm, A., Nielsen, C. K., Andersson, T., & Leandersson, K. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.02354-05 · Cited by 145
c-Jun NH2-Terminal Kinase (JNK)1 and JNK2 Have Distinct Roles in CD8+ T Cell Activation
Conze, D. B., Krahl, T., Kennedy, N. J., Weiss, L., Lumsden, J. M., Hess, P., Flavell, R. A., Gros, G. S. L., Davis, R. J., & Rincón, M. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011508 · Cited by 145
Self-citation
Cutting Edge: Transcriptional Activity of NFATc1 Is Enhanced by the Pim-1 Kinase
Rainio, E.-M., Sandholm, J. A., & Koskinen, P. J. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.4.1524 · Cited by 140
A Constitutively Active NFATc1 Mutant Induces a Transformed Phenotype in 3T3-L1 Fibroblasts
Neal, J. W., & Clipstone, N. A. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m300528200 · Cited by 140
c-Jun NH 2 -Terminal Kinase Inhibits Targeting of the Protein Phosphatase Calcineurin to NFATc1
Chow, C.-W., Dong, C., Flavell, R. A., & Davis, R. J. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.14.5227-5234.2000 · Cited by 140
Self-citation
p38 protects human melanoma cells from UV-induced apoptosis through down-regulation of NF-κB activity and Fas expression
Ivanov, V. N., & Ronai, Z. A. (2000) · Oncogene · doi:10.1038/sj.onc.1203602 · Cited by 125
Prevention of Cardiac Hypertrophy by Calcineurin Inhibition
Olson, E. N., & Molkentin, J. D. (1999) · Circulation Research · doi:10.1161/01.res.84.6.623 · Cited by 126
NFAT as cancer target: Mission possible?
Qin, J., Nag, S. A., Wang, W., Zhou, J., Zhang, W., Wang, H., & Zhang, R. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.07.009 · Cited by 128
CBP/p300 Integrates Raf/Rac-Signaling Pathways in the Transcriptional Induction of NF-ATc during T Cell Activation
Avots, A., Buttmann, M., Chuvpilo, S. A., Escher, C., Smola, U., Bannister, A. J., Rapp, U. R., Kouzarides, T., & Serfling, E. (1999) · Immunity · doi:10.1016/s1074-7613(00)80051-5 · Cited by 125

Authors: Chow, C.-W., Rincón, M., Cavanagh, J., Dickens, M., & Davis, R. J.
Affiliations: University of Vermont (US)
C.-W. Chow, J. Cavanagh, M. Dickens, R. J. Davis, Howard Hughes Medical Institute, Program in Molecular Medicine, Department of Biochemistry and Molecular Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Corresponding author: Davis, Roger J.
ORCID: Cavanagh, Julie
Dickens, Martin
Davis, Roger J.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 1997-11-28
Volume: 278
Issue: 5343
Pages: 1638-1641
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.278.5343.1638
OpenAlex: W2053010478
Cited by: 357
References: 24
Citations by year: 2026: 1 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 11 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 8 · 2013: 3 · 2012: 15
FWCI: 7.70
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders: National Institutes of Health (5r01ca058396-09)
National Cancer Institute (CA 58396, CA65831)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Signaling Pathways in Disease
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Keywords: NFAT4, NFAT, c-Jun N-terminal kinase, calcineurin, JNK phosphorylation, nuclear import, nuclear accumulation, transcription factor regulation, signal transduction
MeSH terms: Animals, Binding Sites, Cell Line, Cell Nucleus, Cytoplasm, DNA-Binding Proteins, Humans, Mutation, Nuclear Proteins, Phosphorylation, Protein Kinases, Recombinant Fusion Proteins, T-Lymphocytes, Transcription Factors, Transcription, Genetic, Signal Transduction, Cyclosporine, Calcium-Calmodulin-Dependent Protein Kinases, Jurkat Cells, COS Cells, Calcineurin, Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase Kinases, JNK Mitogen-Activated Protein Kinases, NFATC Transcription Factors, Calcineurin Inhibitors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nuclear Accumulation of NFAT4 Opposed by the JNK Signal Transduction Pathway

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks