The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Specific Inhibition of Stat3 Signal Transduction by PIAS3
Abstract
The signal transducer and activator of transcription-3 (Stat3) protein is activated by the interleukin 6 (IL-6) family of cytokines, epidermal growth factor, and leptin. A protein named PIAS3 (protein inhibitor of activated STAT) that binds to Stat3 was isolated and characterized. The association of PIAS3 with Stat3 in vivo was only observed in cells stimulated with ligands that cause the activation of Stat3. PIAS3 blocked the DNA-binding activity of Stat3 and inhibited Stat3-mediated gene activation. Although Stat1 is also phosphorylated in response to IL-6, PIAS3 did not interact with Stat1 or affect its DNA-binding or transcriptional activity. The results indicate that PIAS3 is a specific inhibitor of Stat3.
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“Members of the protein inhibitor of activated STAT (PIAS) family, especially PIAS3, are small ubiquitin-like modifier-E3 ligases that bind specifically to STAT3 and abrogate its activity.15”
From Critical analysis of the potential for targeting STAT3 in human malignancy (2013) · cites this paper as [15]
Citations
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Cited by
Sorted by citations
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
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Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway
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JAKS AND STATS: Biological Implications
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Metadata
- Authors
- Chung, C. D., Liao, J., Liu, B., Rao, X., Jay, P., Berta, P., & Shuai, K.
- Affiliations
- University of California, Los Angeles (US)
- Corresponding author
- Chung, Chan D.
- Liao, Jiayu
- Shuai, Ke
- Venue
- Science
- Published
- 1997-12-05
- Volume
- 278
- Issue
- 5344
- Pages
- 1803-1805
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993520606
- Cited by
- 980
- References
- 17
- Citations by year
- 2026: 8 · 2025: 10 · 2024: 11 · 2023: 18 · 2022: 21 · 2021: 27 · 2020: 29 · 2019: 26 · 2018: 28 · 2017: 23 · 2016: 26 · 2015: 30 · 2014: 41 · 2013: 47 · 2012: 35
- FWCI
- 18.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r01ai039612-01)
- National Cancer Institute (T32CA09056, T32CA009056)
- National Institute of Allergy and Infectious Diseases (AI39612)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Keywords
- STAT3, PIAS3, signal transduction inhibition, interleukin-6 family cytokines, epidermal growth factor, leptin, STAT1, transcriptional regulation
- MeSH terms
- Amino Acid Sequence, Animals, Carrier Proteins, Cell Line, DNA, DNA-Binding Proteins, Gene Expression Regulation, Humans, Molecular Sequence Data, Phosphoproteins, Phosphorylation, Recombinant Fusion Proteins, Transfection, Tumor Cells, Cultured, Tumor Necrosis Factor-alpha, Signal Transduction, Transcriptional Activation, Trans-Activators, Interleukin-6, NF-kappa B, Interferon-alpha, Phosphotyrosine, Intracellular Signaling Peptides and Proteins, STAT1 Transcription Factor, STAT3 Transcription Factor, Protein Inhibitors of Activated STAT, Interferon Regulatory Factor-1, Mice
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