Stat3 and Stat4: members of the family of signal transducers and activators of transcription.
Open accessAbstract
The deduced amino acid sequence of two members of the signal transducers and activators of transcription (STAT) family from the mouse are described. Comparison with the deduced protein sequence of the two previously described genes (Stat91 and Stat113), discovered because of their activation as transcription factors after interferon-induced tyrosine phosphorylation, shows several highly conserved regions, including the putative SH3 and SH2 domains. The conserved amino acid stretches likely point to conserved domains that enable these proteins to carry out the several required functions they are known and proposed to carry out. While Stat1 and Stat3 are widely expressed, Stat4 expression is restricted to testis, thymus, and spleen. Antiserum to Stat3 detects a major approximately 92-kDa protein and a minor approximately 89-kDa protein, while antiserum to Stat4 precipitates one major protein of approximately 89 kDa.
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The tissue-specific distribution of some STATs may contribute to their functional specificity.
“the tissue-specific distribution of some STATs may also contribute to their functional specificity (45”
From STAT3 Contributes to the Mitogenic Response of Hepatocytes during Liver Regeneration (2002) · cites this paper as [45]
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- Authors
- Zhong, Z., Wen, Z., & Darnell, J. E.
- Affiliations
- Rockefeller University (US)
- Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021.
- ORCID
- Wen, Z
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1994-05-24
- Volume
- 91
- Issue
- 11
- Pages
- 4806-4810
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC43877
- OpenAlex
- W2070242833
- Cited by
- 397
- References
- 0
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 13 · 2023: 4 · 2022: 3 · 2021: 9 · 2020: 9 · 2019: 6 · 2018: 13 · 2017: 6 · 2016: 10 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 12
- FWCI
- 16.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Allergy and Infectious Diseases (R01AI032489, AI32489)
- Topics
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- STAT3, STAT4, STAT family, signal transducer and activator of transcription, STAT1, transcription factors, SH2 domain, SH3 domain, protein sequence conservation, tissue-specific gene expression, mice
- MeSH terms
- Amino Acid Sequence, Animals, Base Sequence, Cell Line, Cloning, Molecular, DNA, DNA-Binding Proteins, Humans, Molecular Sequence Data, RNA, Messenger, Tissue Distribution, Transcription Factors, Signal Transduction, Transcriptional Activation, Trans-Activators, Conserved Sequence, Sequence Homology, Amino Acid, STAT3 Transcription Factor, STAT4 Transcription Factor, Mice
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