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Interleukin-2 Receptor β Chain Gene: Generation of Three Receptor Forms by Cloned Human α and β Chain cDNA's
Abstract
Interleukin-2 (IL-2) binds to two distinct receptor molecules, the IL-2 receptor α (IL-2Rα, p55) chain and the newly identified IL-2 receptor β (IL-2Rβ, p70-75) chain. The cDNA encoding the human IL-2Rβ chain has now been isolated. The overall primary structure of the IL-2Rβ chain shows no apparent homology to other known receptors. Unlike the IL-2Rα chain, the IL-2Rβ chain has a large cytoplasmic region in which a functional domain (or domains) mediating an intracellular signal transduction pathway (or pathways) may be embodied. The cDNA-encoded β chain binds and internalizes IL-2 when expressed on T lymphoid cells but not fibroblast cells. Furthermore, the cDNA gives rise to the generation of high-affinity IL-2 receptor when co-expressed with the IL-2Rα chain cDNA.
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Cited by
Molecular cloning and expression of an IL-6 signal transducer, gp130
Hibi, M., Murakami, M., Saito, M., Hirano, T., Taga, T., & Kishimoto, T. (1990) · Cell · doi:10.1016/0092-8674(90)90411-7 · Cited by 1,039
Molecular cloning and expression of a receptor for human tumor necrosis factor
Schall, T. J., Lewis, M., Koller, K. J., Lee, A., Rice, G. C., Wong, G. H. W., Gatanaga, T., Granger, G. A., Lentz, R., Raab, H., et al. (1990) · Cell · doi:10.1016/0092-8674(90)90816-w · Cited by 964
Hallböök, F., Ibáñez, C. F., & Persson, H. (1991) · Neuron · doi:10.1016/0896-6273(91)90180-8 · Cited by 834
Interleukin-6 and its receptor: a paradigm for cytokines
Kishimoto, T., Akira, S., & Taga, T. (1992) · Science · doi:10.1126/science.1411569 · Cited by 665
Biology and regulation of IL-2: from molecular mechanisms to human therapy
Spolski, R., Li, P., & Leonard, W. J. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0046-y · Cited by 637
Metadata
- Authors
- Hatakeyama, M., Tsudo, M., Minamoto, S., Kono, T., Doi, T., Miyata, T., Miyasaka, M., & Taniguchi, T.
- Venue
- Science
- Published
- 1989-05-05
- Volume
- 244
- Issue
- 4904
- Pages
- 551-556
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2096746841
- Cited by
- 677
- References
- 0
- FWCI
- 49.90
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Hatakeyama, M., Tsudo, M., Minamoto, S., Kono, T., Doi, T., Miyata, T., Miyasaka, M., & Taniguchi, T. (1989). Interleukin-2 Receptor β Chain Gene: Generation of Three Receptor Forms by Cloned Human α and β Chain cDNA's. Science. https://doi.org/10.1126/science.2785715
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
