The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Molecular Mimicry by Herpes Simplex Virus-Type 1: Autoimmune Disease After Viral Infection
Abstract
Viral infection is sometimes associated with the initiation or exacerbation of autoimmune disease, although the underlying mechanisms remain unclear. One proposed mechanism is that viral determinants that mimic host antigens trigger self-reactive T cell clones to destroy host tissue. An epitope expressed by a coat protein of herpes simplex virus–type 1 (HSV-1) KOS strain has now been shown to be recognized by autoreactive T cells that target corneal antigens in a murine model of autoimmune herpes stromal keratitis. Mutant HSV-1 viruses that lacked this epitope did not induce autoimmune disease. Thus, expression of molecular mimics can influence the development of autoimmune disease after viral infection.
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Cites
Immunoregulatory mechanisms of the eye
Streilein, J. W., Wilbanks, G. A., & Cousins, S. W. (1992) · Journal of Neuroimmunology · doi:10.1016/0165-5728(92)90253-h · Cited by 157
Cited by
Viruses and Autoimmunity: A Review on the Potential Interaction and Molecular Mechanisms
Smatti, M. K., Cyprian, F. S., Nasrallah, G. K., Al Thani, A. A., Almishal, R. O., & Yassine, H. M. (2019) · Viruses · doi:10.3390/v11080762 · Cited by 544
Mechanisms for the induction of autoimmunity by infectious agents
Wucherpfennig, K. W. (2001) · Journal of Clinical Investigation · doi:10.1172/jci14235 · Cited by 435
From Infection to Autoimmunity
Fairweather, D., Kaya, Z., Shellam, G. R., Lawson, C. M., & Rose, N. R. (2001) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0492 · Cited by 328
Recent Progress in Herpes Simplex Virus Immunobiology and Vaccine Research
Koelle, D. M., & Corey, L. (2003) · Clinical Microbiology Reviews · doi:10.1128/cmr.16.1.96-113.2003 · Cited by 263
Molecular Mimicry, Microbial Infection, and Autoimmune Disease: Evolution of the Concept
Oldstone, M. B. A. (2005) · Current Topics in Microbiology and Immunology · doi:10.1007/3-540-30791-5_1 · Cited by 146
Metadata
- Authors
- Zhao, Z.-S., Granucci, F., Yeh, L., Schaffer, P. A., & Cantor, H.
- Venue
- Science
- Published
- 1998-02-27
- Volume
- 279
- Issue
- 5355
- Pages
- 1344-1347
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2016333231
- Cited by
- 512
- References
- 1
- FWCI
- 36.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- The paper
- Zhao, Z.-S., Granucci, F., Yeh, L., Schaffer, P. A., & Cantor, H. (1998). Molecular Mimicry by Herpes Simplex Virus-Type 1: Autoimmune Disease After Viral Infection. Science. https://doi.org/10.1126/science.279.5355.1344
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
