The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Role of Rac1 and Oxygen Radicals in Collagenase-1 Expression Induced by Cell Shape Change
Abstract
Integrin-mediated reorganization of cell shape leads to an altered cellular phenotype. Disruption of the actin cytoskeleton, initiated by binding of soluble antibody to α5β1 integrin, led to increased expression of the collagenase-1 gene in rabbit synovial fibroblasts. Activation of the guanosine triphosphate–binding protein Rac1, which was downstream of the integrin, was necessary for this process, and expression of activated Rac1 was sufficient to increase expression of collagenase-1. Rac1 activation generated reactive oxygen species that were essential for nuclear factor kappa B–dependent transcriptional regulation of interleukin-1α, which, in an autocrine manner, induced collagenase-1 gene expression. Remodeling of the extracellular matrix and consequent alterations of integrin-mediated adhesion and cytoarchitecture are central to development, wound healing, inflammation, and malignant disease. The resulting activation of Rac1 may lead to altered gene regulation and alterations in cellular morphogenesis, migration, and invasion.
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Citations
Cites
A role for Rho in Ras transformation
Qiu, R. G., Chen, J., McCormick, F., & Symons, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.25.11781 · Cited by 533
Self-citation
Cited by
Free Radicals in the Physiological Control of Cell Function
Dröge, W. (2002) · Physiological Reviews · doi:10.1152/physrev.00018.2001 · Cited by 9,855
How Matrix Metalloproteinases Regulate Cell Behavior
Sternlicht, M. D., & Werb, Z. (2001) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.17.1.463 · Cited by 3,959
Self-citationReactive oxygen species in cancer
Liou, G.-Y., & Storz, P. (2010) · Free Radical Research · doi:10.3109/10715761003667554 · Cited by 3,382
RHO GTPASES: Biochemistry and Biology
Jaffe, A. B., & Hall, A. (2005) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.21.020604.150721 · Cited by 3,009
Oxidant signals and oxidative stress
Finkel, T. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00002-4 · Cited by 1,393
Metadata
- Authors
- Kheradmand, F., Werner, E., Tremble, P., Symons, M., & Werb, Z.
- Venue
- Science
- Published
- 1998-05-08
- Volume
- 280
- Issue
- 5365
- Pages
- 898-902
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1993808418
- Cited by
- 391
- References
- 1
- FWCI
- 12.27
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kheradmand, F., Werner, E., Tremble, P., Symons, M., & Werb, Z. (1998). Role of Rac1 and Oxygen Radicals in Collagenase-1 Expression Induced by Cell Shape Change. Science. https://doi.org/10.1126/science.280.5365.898
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
