Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling

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Altered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants

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Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development

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Niemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis

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Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis

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Two Critical Periods of Sonic Hedgehog Signaling Required for the Specification of Motor Neuron Identity

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Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome

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Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly

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Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene Islet-1

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Autoproteolysis in hedgehog protein biogenesis

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The product of hedgehog autoproteolytic cleavage active in local and long-range signalling

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Control of cell pattern in the neural tube: Motor neuron induction by diffusible factors from notochord and floor plate

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Distribution of Sonic hedgehog peptides in the developing chick and mouse embryo

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Patterning of the embryonic forebrain

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Teratogenic compounds of Veratrum californicum (Durand). V. Comparison of cyclopian effects of steroidal alkaloids from the plant and structurally related compounds from other sources

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Inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in hepatoma tissue culture cells by pure cholesterol and several cholesterol derivatives. Evidence supporting two distinct mechanisms.20l.

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Multiple roles of cholesterol in hedgehog protein biogenesis and signaling.Preprint

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Subcellular localization of the segment polarity protein patched suggests an interaction with the wingless reception complex in Drosophila embryos

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Glycoprotein 330/Low Density Lipoprotein Receptor-related Protein-2 Mediates Endocytosis of Low Density Lipoproteins via Interaction with Apolipoprotein B100

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Progesterone Inhibits Cholesterol Biosynthesis in Cultured Cells

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3-Hydroxy-3-methylglutaryl coenzyme A reductase activity in cultured fibroblasts from patients with mevalonate kinase deficiency: differential response to lipid supplied by fetal bovine serum in tissue culture medium.

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Inhibition of Cholesterol Synthesis and Cell Growth by 24(R, S),25-Iminolanosterol and Triparanol in Cultured Rat Hepatoma Cells

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The effects of BM 15.766, an inhibitor of 7-dehydrocholesterol δ7-reductase∗, on cholesterol biosynthesis in primary rat hepatocytes

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Effects of drugs on cholesterol esterification in normal and Niemann-Pick type C fibroblasts: AY-9944, other cationic amphiphilic drugs and DMSO

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Cholesterol homeostasis is modulated by amphiphiles at transcriptional and post-transcriptional loci

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Vertebrate Smoothened functions at the primary cilium

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Inhibition of Hedgehog signaling by direct binding of cyclopamine to SmoothenedPreprint

Chen, J., Taipale, J., Cooper, M. K., & Beachy, P. A. (2002) · Genes & Development · doi:10.1101/gad.1025302 · Cited by 1,464

Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine

Taipale, J., Chen, J., Cooper, M. K., Wang, B., Mann, R. K., Milenković, L., Scott, M. P., & Beachy, P. A. (2000) · Nature · doi:10.1038/35023008 · Cited by 1,314

Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours

Berman, D. M., Karhadkar, S. S., Maitra, A., Oca, R. M. D., Gerstenblith, M. R., Briggs, K. J., Parker, A. R., Shimada, Y., Eshleman, J. R., Watkins, D. N., et al. (2003) · Nature · doi:10.1038/nature01972 · Cited by 1,251

Hedgehog: functions and mechanisms

Varjosalo, M., & Taipale, J. (2008) · Genes & Development · doi:10.1101/gad.1693608 · Cited by 1,217

From Teratogens to Potential Therapeutics: Natural Inhibitors of the Hedgehog Signaling Network Come of Age

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Mechanistic Investigation of Veratrum Alkaloid-Induced Mammalian Teratogenesis

Gaffield, W., Incardona, J. P., Kapur, R. P., & Roelink, H. (1999) · ACS symposium series · doi:10.1021/bk-2000-0745.ch012

The teratogenic Veratrum alkaloid cyclopamine inhibits Sonic hedgehog signal transduction

Incardona, J. P., Gaffield, W., Kapur, R. P., & Roelink, H. (1998) · Development · doi:10.1242/dev.125.18.3553 · Cited by 654

A teratogen inhibiting cholesterol biosynthesis phenocopies Sonic Hedgehog developmental gene mutation in rat embryos

Kolf‐Clauw, M., Clotmarr, F., Roux, C., & Picard, J. (1998) · Toxicology Letters · doi:10.1016/s0378-4274(98)80829-1

The role of cholesterol in Shh signaling and teratogen-induced holoprosencephaly

Incardona, J. P., & Roelink, H. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000653 · Cited by 76