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Teratogen-Mediated Inhibition of Target Tissue Response to Shh Signaling
Abstract
Veratrum alkaloids and distal inhibitors of cholesterol biosynthesis have been studied for more than 30 years as potent teratogens capable of inducing cyclopia and other birth defects. Here, it is shown that these compounds specifically block the Sonic hedgehog (Shh) signaling pathway. These teratogens did not prevent the sterol modification of Shh during autoprocessing but rather inhibited the response of target tissues to Shh, possibly acting through the sterol sensing domain within the Patched protein regulator of Shh response.
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“Low cholesterol levels may impair sonic hedgehog signaling and cause the striking developmental malformations. Activity of this signaling factor and its distribution are regulated by posttranslational attachment of cholesterol to its amino terminus [26,27,28].”
From Loss of Mevalonate/Cholesterol Homeostasis in the Brain: A Focus on Autism Spectrum Disorder and Rett Syndrome (2019) · cites this paper as [27]
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Cites
Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function
Chiang, C. C., Litingtung, Y., Lee, E., Young, K. E., Corden, J. L., Westphal, H., & Beachy, P. A. (1996) · Nature · doi:10.1038/383407a0 · Cited by 3,062
Self-citationAltered Neural Cell Fates and Medulloblastoma in Mouse patched Mutants
Goodrich, L. V., Milenković, L., Higgins, K. M., & Scott, M. P. (1997) · Science · doi:10.1126/science.277.5329.1109 · Cited by 1,696
Cholesterol Modification of Hedgehog Signaling Proteins in Animal Development
Porter, J. A., Young, K. E., & Beachy, P. A. (1996) · Science · doi:10.1126/science.274.5285.255 · Cited by 1,360
Self-citationNiemann-Pick C1 Disease Gene: Homology to Mediators of Cholesterol Homeostasis
Carstea, E. D., Morris, J. A., Coleman, K. G., Loftus, S. K., Zhang, D., Cummings, C., Gu, J., Rosenfeld, M. A., Pavan, W. J., Krizman, D. B., et al. (1997) · Science · doi:10.1126/science.277.5323.228 · Cited by 1,293
Roelink, H., Porter, J. A., Chiang, C. C., Tanabe, Y., Chang, D. T., Beachy, P. A., & Jessell, T. M. (1995) · Cell · doi:10.1016/0092-8674(95)90397-6 · Cited by 888
Self-citationEricson, J., Brenner‐Morton, S., Kawakami, A., Roelink, H., & Jessell, T. M. (1996) · Cell · doi:10.1016/s0092-8674(00)81386-0 · Cited by 870
Defective cholesterol biosynthesis associated with the Smith-Lemli-Opitz syndrome
Tint, G. S., Irons, M., Elias, E. R., Batta, A. K., Frieden, R., Chen, T. S., & Salen, G. (1994) · New England Journal of Medicine · doi:10.1056/nejm199401133300205 · Cited by 798
Identification of Sonic hedgehog as a candidate gene responsible for holoprosencephaly
Belloni, E., Muenke, M., Roessler, E., Traverse, G., Siegel-Bartelt, J., Frumkin, A., Mitchell, H. F., Donis-Keller, H., Helms, C. A., Hing, A. V., et al. (1996) · Nature Genetics · doi:10.1038/ng1196-353 · Cited by 643
Early Stages of Motor Neuron Differentiation Revealed by Expression of Homeobox Gene Islet-1
Ericson, J., Thor, S., Edlund, T., Jessell, T. M., & Yamada, T. (1992) · Science · doi:10.1126/science.1350865 · Cited by 620
Autoproteolysis in hedgehog protein biogenesis
Lee, J., Ekker, S. C., von Kessler, D. P., Porter, J. A., Sun, B. I., & Beachy, P. A. (1994) · Science · doi:10.1126/science.7985023 · Cited by 547
Self-citation
Research works printed but not linked: 2
- Roux C., Arch. Fr. Pediatr.21, 451 (1964); C. R. Soc. Biol. 160, 1353 (1966).
- Liem K. F., Tremml G., Roelink H., Jessell T. M., ibid82, 969 (1995).
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Self-citationRomer, J. T., Kimura, H., Magdaleno, S. M., Sasai, K., Fuller, C. E., Baines, H., Connelly, M., Stewart, C. F., Gould, S. E., Rubin, L. L., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.08.019 · Cited by 521
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Self-citationFrank-Kamenetsky, M. D., Zhang, X. M., Bottega, S., Guicherit, O. M., Wichterle, H., Dudek, H., Bumcrot, D. A., Wang, F. Y., Jones, S. S., Shulok, J. R., et al. (2002) · Journal of Biology · doi:10.1186/1475-4924-1-10 · Cited by 491
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Balaskas, N., Ribeiro, A., Panovska‐Griffiths, J., Dessaud, É., Sasai, N., Page, K. M., Briscoe, J., & Ribes, V. (2012) · Cell · doi:10.1016/j.cell.2011.10.047 · Cited by 474
Varnat, F., Duquet, A., Malerba, M., Zbinden, M., Mas, C., Gervaz, P., & Altaba, A. R. I. (2009) · EMBO Molecular Medicine · doi:10.1002/emmm.200900039 · Cited by 465
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Braverman, N., Lin, P., Moebius, F. F., Obie, C., Moser, A., Glossmann, H., Wilcox, W. R., Rimoin, D. L., Smith, M., Kratz, L., et al. (1999) · Nature Genetics · doi:10.1038/10357 · Cited by 285
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Gupta, S. K., Takebe, N., & LoRusso, P. M. (2010) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758834010366430 · Cited by 268
Helms, J. A., & Schneider, R. A. (2003) · Nature · doi:10.1038/nature01656 · Cited by 256
CNS-derived glia ensheath peripheral nerves and mediate motor root development
Kucenas, S., Takada, N., Park, H., Woodruff, E. A., Broadie, K. S., & Appel, B. (2008) · Nature Neuroscience · doi:10.1038/nn2025 · Cited by 248
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Briscoe, J., & Ericson, J. (1999) · Seminars in Cell and Developmental Biology · doi:10.1006/scdb.1999.0295 · Cited by 256
Cholesterol activates the G-protein coupled receptor Smoothened to promote Hedgehog signaling
Luchetti, G., Sircar, R., Kong, J. H., Nachtergaele, S., Sagner, A., Byrne, E. F. X., Covey, D. F., Siebold, C., & Rohatgi, R. (2016) · eLife · doi:10.7554/elife.20304 · Cited by 261
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Altaba, A. R. I. (1999) · Trends in Genetics · doi:10.1016/s0168-9525(99)01840-5 · Cited by 250
Unique functions of Sonic hedgehog signaling during external genitalia development
Haraguchi, R., Mo, R., Hui, C., Motoyama, J., Makino, S., Shiroishi, T., Gaffield, W., & Yamada, G. (2001) · Development · doi:10.1242/dev.128.21.4241 · Cited by 251
Regulation of endoplasmic reticulum cholesterol by plasma membrane cholesterol
Lange, Y., Ye, J., Rigney, M., & Steck, T. L. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32101-5 · Cited by 245
A crucial requirement for Hedgehog signaling in small cell lung cancer
Park, K.-S., Martelotto, L. G., Peifer, M., Sos, M. L., Karnezis, A. N., Mahjoub, M. R., Bernard, K., Conklin, J. F., Szczepny, A., Yuan, J., et al. (2011) · Nature Medicine · doi:10.1038/nm.2473 · Cited by 247
Metadata
- Authors
- Cooper, M. K., Porter, J. A., Young, K. E., & Beachy, P. A.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Porter, Jeffery A.
- Beachy, Philip A.
- ORCID
- Beachy, Philip A.
- Venue
- Science
- Published
- 1998-06-05
- Volume
- 280
- Issue
- 5369
- Pages
- 1603-1607
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2002249795
- Cited by
- 848
- References
- 26
- Citations by year
- 2026: 7 · 2025: 7 · 2024: 12 · 2023: 13 · 2022: 18 · 2021: 9 · 2020: 16 · 2019: 25 · 2018: 22 · 2017: 25 · 2016: 26 · 2015: 27 · 2014: 34 · 2013: 31 · 2012: 50
- FWCI
- 14.39
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Pharmacological Effects and Toxicity Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Kidney Cyst Diseases
- Keywords
- teratogens, Sonic hedgehog signaling, veratrum alkaloids, cholesterol biosynthesis inhibitors, cyclopia, congenital malformations, sterol-sensing domain
- MeSH terms
- Abnormalities, Drug-Induced, Patched Receptors, Animals, trans-1,4-Bis(2-chlorobenzaminomethyl)cyclohexane Dihydrochloride, Cell Membrane, Central Nervous System, Chick Embryo, Cholesterol, DNA-Binding Proteins, Endoplasmic Reticulum, Membrane Proteins, Muscle Proteins, Nerve Tissue Proteins, Nuclear Proteins, Proteins, Receptors, Cell Surface, Teratogens, Tomatine, Transcription Factors, Triparanol, Veratrum Alkaloids, Signal Transduction, Trans-Activators, Holoprosencephaly, Homeodomain Proteins, Culture Techniques, Hepatocyte Nuclear Factor 3-beta, PAX7 Transcription Factor, Hedgehog Proteins, LIM-Homeodomain Proteins
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