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Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα 13
Abstract
Signaling pathways that link extracellular factors to activation of the monomeric guanosine triphosphatase (GTPase) Rho control cytoskeletal rearrangements and cell growth. Heterotrimeric guanine nucleotide–binding proteins (G proteins) participate in several of these pathways, although their mechanisms are unclear. The GTPase activities of two G protein α subunits, Gα 12 and Gα 13 , are stimulated by the Rho guanine nucleotide exchange factor p115 RhoGEF. Activated Gα 13 bound tightly to p115 RhoGEF and stimulated its capacity to catalyze nucleotide exchange on Rho. In contrast, activated Gα 12 inhibited stimulation by Gα 13 . Thus, p115 RhoGEF can directly link heterotrimeric G protein α subunits to regulation of Rho.
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Cited by
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Konermann, S., Brigham, M. D., Trevino, A. E., Joung, J., Abudayyeh, O. O., Barcena, C., Hsu, P. D., Habib, N., Gootenberg, J. S., Nishimasu, H., et al. (2015) · Nature · doi:10.1038/nature14136 · Cited by 2,825
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
Rossman, K. L., Der, C. J., & Sondek, J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1587 · Cited by 1,697
Burridge, K., & Wennerberg, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00003-0 · Cited by 1,578
Somlyo, A. P., & Somlyo, A. V. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-2-00177.x · Cited by 1,207
p115 RhoGEF, a GTPase Activating Protein for Gα 12 and Gα 13
Kozasa, T., Jiang, X., Hart, M. J., Sternweis, P. M., Singer, W. D., Gilman, A. G., Bollag, G., & Sternweis, P. C. (1998) · Science · doi:10.1126/science.280.5372.2109 · Cited by 854
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Metadata
- Authors
- Hart, M. J., Jiang, X., Kozasa, T., Roscoe, W., Singer, W. D., Gilman, A. G., Sternweis, P. C., & Bollag, G.
- Venue
- Science
- Published
- 1998-06-26
- Volume
- 280
- Issue
- 5372
- Pages
- 2112-2114
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2144554951
- Cited by
- 779
- References
- 0
- FWCI
- 21.05
- Type
- journal article
- Language
- en
- Open access
- closed
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- Hart, M. J., Jiang, X., Kozasa, T., Roscoe, W., Singer, W. D., Gilman, A. G., Sternweis, P. C., & Bollag, G. (1998). Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα 13. Science. https://doi.org/10.1126/science.280.5372.2112
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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