The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
p115 RhoGEF, a GTPase Activating Protein for Gα 12 and Gα 13
Abstract
Members of the regulators of G protein signaling (RGS) family stimulate the intrinsic guanosine triphosphatase (GTPase) activity of the α subunits of certain heterotrimeric guanine nucleotide–binding proteins (G proteins). The guanine nucleotide exchange factor (GEF) for Rho, p115 RhoGEF, has an amino-terminal region with similarity to RGS proteins. Recombinant p115 RhoGEF and a fusion protein containing the amino terminus of p115 had specific activity as GTPase activating proteins toward the α subunits of the G proteins G 12 and G 13 , but not toward members of the G s , G i , or G q subfamilies of Gα proteins. This GEF may act as an intermediary in the regulation of Rho proteins by G 13 and G 12 .
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Self-citationDirect Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα 13
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Self-citationGAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits
Berman, D. M., Wilkie, T. M., & Gilman, A. G. (1996) · Cell · doi:10.1016/s0092-8674(00)80117-8 · Cited by 729
Self-citationRGS Proteins and Signaling by Heterotrimeric G Proteins
Dohlman, H. G., & Thorner, J. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.7.3871 · Cited by 518
Gα12 and Gα13 Stimulate Rho-dependent Stress Fiber Formation and Focal Adhesion Assembly
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Self-citationVascular System Defects and Impaired Cell Chemokinesis as a Result of Gα 13 Deficiency
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The drosophila gastrulation gene concertina encodes a Gα-like protein
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Cited by
GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors
Rossman, K. L., Der, C. J., & Sondek, J. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1587 · Cited by 1,697
Burridge, K., & Wennerberg, K. (2004) · Cell · doi:10.1016/s0092-8674(04)00003-0 · Cited by 1,578
Somlyo, A. P., & Somlyo, A. V. (2000) · The Journal of Physiology · doi:10.1111/j.1469-7793.2000.t01-2-00177.x · Cited by 1,207
G-protein-coupled receptors and signaling networks: emerging paradigms
Marinissen, M. J., & Gutkind, J. S. (2001) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)01678-3 · Cited by 1,049
Regulation, signaling, and physiological functions of G-Proteins
Syrovatkina, V., Alegre, K. O., Dey, R., & Huang, X.-Y. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.08.002 · Cited by 498
Metadata
- Authors
- Kozasa, T., Jiang, X., Hart, M. J., Sternweis, P. M., Singer, W. D., Gilman, A. G., Bollag, G., & Sternweis, P. C.
- Venue
- Science
- Published
- 1998-06-26
- Volume
- 280
- Issue
- 5372
- Pages
- 2109-2111
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2022723700
- Cited by
- 854
- References
- 17
- FWCI
- 20.94
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kozasa, T., Jiang, X., Hart, M. J., Sternweis, P. M., Singer, W. D., Gilman, A. G., Bollag, G., & Sternweis, P. C. (1998). p115 RhoGEF, a GTPase Activating Protein for Gα 12 and Gα 13. Science. https://doi.org/10.1126/science.280.5372.2109
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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