The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Mixer , a Homeobox Gene Required for Endoderm Development
Abstract
An expression cloning strategy in Xenopus laevis was used to isolate a homeobox-containing gene, Mixer , that can cause embryonic cells to form endoderm. Mixer transcripts are found specifically in the prospective endoderm of gastrula, which coincides with the time and place that endodermal cells become histologically distinct and irreversibly determined. Loss-of-function studies with a dominant inhibitory mutant demonstrate that Mixer activity is required for endoderm development. In particular, the expression of Sox17 α and Sox17 β, two previously identified endodermal determinants, require Mixer function. Together, these data suggest that Mixer is an embryonic transcription factor involved in specifying the endodermal germ layer.
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Bouwmeester, T., Kim, S.-H., Sasai, Y., Lu, B., & Robertis, E. M. D. (1996) · Nature · doi:10.1038/382595a0 · Cited by 759
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Self-citationDepletion of definitive gut endoderm in Sox17 -null mutant mice
Kanai-Azuma, M., Kanai, Y., Gad, J. M., Tajima, Y., Taya, C., Kurohmaru, M., Sanai, Y., Yonekawa, H., Yazaki, K., Tam, P. P. L., et al. (2002) · Development · doi:10.1242/dev.129.10.2367 · Cited by 704
Borchers, A., & Pieler, T. (2010) · Genes · doi:10.3390/genes1030413 · Cited by 506
The establishment of spemann's organizer and patterning of the vertebrate embryo
De Robertis, E. M., Larraín, J., Oelgeschläger, M., & Wessely, O. (2000) · Nature Reviews Genetics · doi:10.1038/35042039 · Cited by 429
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Metadata
- Authors
- Henry, G. L., & Melton, D. A.
- Venue
- Science
- Published
- 1998-07-03
- Volume
- 281
- Issue
- 5373
- Pages
- 91-96
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2044095291
- Cited by
- 204
- References
- 1
- FWCI
- 7.77
- Type
- journal article
- Language
- en
- Open access
- closed
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- Henry, G. L., & Melton, D. A. (1998). Mixer , a Homeobox Gene Required for Endoderm Development. Science. https://doi.org/10.1126/science.281.5373.91
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
