The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Disruption of a Neuropeptide Gene, flp-1 , Causes Multiple Behavioral Defects in Caenorhabditis elegans
Abstract
Neuropeptides serve as important signaling molecules in the nervous system. The FMRFamide (Phe-Met-Arg-Phe-amide)–related neuropeptide gene family in the nematode Caenorhabditis elegans is composed of at least 18 genes that may encode 53 distinct FMRFamide-related peptides. Disruption of one of these genes, flp-1 , causes numerous behavioral defects, including uncoordination, hyperactivity, and insensitivity to high osmolarity. Conversely, overexpression of flp-1 results in the reciprocal phenotypes. On the basis of epistasis analysis, flp-1 gene products appear to signal upstream of a G protein–coupled second messenger system. These results demonstrate that varying the levels of FLP-1 neuropeptides can profoundly affect behavior and that members of this large neuropeptide gene family are not functionally redundant in C. elegans .
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Cites
The structure of the nervous system of the nematode Caenorhabditis elegans
White, J. G., Southgate, E., Thomson, J. N., & Brenner, S. (1986) · Philosophical Transactions of the Royal Society of London. B, Biological Sciences · doi:10.1098/rstb.1986.0056 · Cited by 5,589
Bargmann, C. I., & Horvitz, H. R. (1991) · Neuron · doi:10.1016/0896-6273(91)90276-6 · Cited by 740
Cited by
Cao, J., Packer, J. S., Ramani, V., Cusanovich, D. A., Huynh, C., Daza, R., Qiu, X., Lee, C., Furlan, S. N., Steemers, F. J., et al. (2017) · doi:10.1101/104844 · Cited by 1,402
Neurobiology of the Caenorhabditis elegans Genome
Bargmann, C. I. (1998) · Science · doi:10.1126/science.282.5396.2028 · Cited by 929
Nässel, D. R. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00057-6 · Cited by 481
New insights into copper monooxygenases and peptide amidation: Structure, mechanism and function
Prigge, S. T., Mains, R. E., Eipper, B. A., & Amzel* **, L. M. (2000) · Cellular and Molecular Life Sciences · doi:10.1007/pl00000763 · Cited by 460
Speese, S., Petrie, M., Schuske, K., Ailion, M., Ann, K., Iwasaki, K., Jorgensen, E. M., & Martin, T. F. J. (2007) · Journal of Neuroscience · doi:10.1523/jneurosci.1466-07.2007 · Cited by 333
Metadata
- Authors
- Nelson, L. S., Rosoff, M. L., & Li, C.
- Venue
- Science
- Published
- 1998-09-11
- Volume
- 281
- Issue
- 5383
- Pages
- 1686-1690
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030678592
- Cited by
- 172
- References
- 2
- FWCI
- 5.35
- Type
- journal article
- Language
- en
- Open access
- closed
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- Nelson, L. S., Rosoff, M. L., & Li, C. (1998). Disruption of a Neuropeptide Gene, flp-1 , Causes Multiple Behavioral Defects in Caenorhabditis elegans. Science. https://doi.org/10.1126/science.281.5383.1686
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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