The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
PIP 2 and PIP as Determinants for ATP Inhibition of K ATP Channels
Abstract
Adenosine triphosphate (ATP)–sensitive potassium (K ATP ) channels couple electrical activity to cellular metabolism through their inhibition by intracellular ATP. ATP inhibition of K ATP channels varies among tissues and is affected by the metabolic and regulatory state of individual cells, suggesting involvement of endogenous factors. It is reported here that phosphatidylinositol-4,5-bisphosphate (PIP 2 ) and phosphatidylinositol-4-phosphate (PIP) controlled ATP inhibition of cloned K ATP channels (K ir 6.2 and SUR1). These phospholipids acted on the K ir 6.2 subunit and shifted ATP sensitivity by several orders of magnitude. Receptor-mediated activation of phospholipase C resulted in inhibition of K ATP -mediated currents. These results represent a mechanism for control of excitability through phospholipids.
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Cites
Ionic mechanisms involved in the regulation of insulin secretion by muscarinic agonists
Bordin, S., Boschero, A. C., Carneiro, E. M., & Atwater, I. (1995) · The Journal of Membrane Biology · doi:10.1007/bf00207273 · Cited by 67
Cited by
Phosphoinositides: Tiny Lipids With Giant Impact on Cell Regulation
Balla, T. (2013) · Physiological Reviews · doi:10.1152/physrev.00028.2012 · Cited by 1,638
Inwardly Rectifying Potassium Channels: Their Structure, Function, and Physiological Roles
Hibino, H., Inanobe, A., Furutani, K., Murakami, S., Findlay, I., & Kurachi, Y. (2010) · Physiological Reviews · doi:10.1152/physrev.00021.2009 · Cited by 1,539
KATP channels as molecular sensors of cellular metabolism
Nichols, C. G. (2006) · Nature · doi:10.1038/nature04711 · Cited by 851
PIP 2 Is a Necessary Cofactor for Ion Channel Function: How and Why?
Suh, B.-C., & Hille, B. (2008) · Annual Review of Biophysics · doi:10.1146/annurev.biophys.37.032807.125859 · Cited by 646
Hydrogen Sulfide as Endothelium-Derived Hyperpolarizing Factor Sulfhydrates Potassium Channels
Mustafa, A. K., Sikka, G., Gazi, S. K., Steppan, J., Jung, S. M., Bhunia, A. K., Barodka, V. M., Gazi, F. K., Barrow, R. K., Wang, R., et al. (2011) · Circulation Research · doi:10.1161/circresaha.111.240242 · Cited by 622
Metadata
- Authors
- Baukrowitz, T., Schulte, U., Oliver, D., Herlitze, S., Krauter, T., Tucker, S. J., Ruppersberg, J. P., & Fakler, B.
- Venue
- Science
- Published
- 1998-11-06
- Volume
- 282
- Issue
- 5391
- Pages
- 1141-1144
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2082648108
- Cited by
- 513
- References
- 1
- FWCI
- 13.96
- Type
- journal article
- Language
- en
- Open access
- closed
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- Baukrowitz, T., Schulte, U., Oliver, D., Herlitze, S., Krauter, T., Tucker, S. J., Ruppersberg, J. P., & Fakler, B. (1998). PIP 2 and PIP as Determinants for ATP Inhibition of K ATP Channels. Science. https://doi.org/10.1126/science.282.5391.1141
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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