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Role of α-Dystroglycan as a Schwann Cell Receptor for Mycobacterium leprae
Abstract
α-Dystroglycan (α-DG) is a component of the dystroglycan complex, which is involved in early development and morphogenesis and in the pathogenesis of muscular dystrophies. Here, α-DG was shown to serve as a Schwann cell receptor for Mycobacterium leprae , the causative organism of leprosy. Mycobacterium leprae specifically bound to α-DG only in the presence of the G domain of the α2 chain of laminin-2. Native α-DG competitively inhibited the laminin-2–mediated M. leprae binding to primary Schwann cells. Thus, M. leprae may use linkage between the extracellular matrix and cytoskeleton through laminin-2 and α-DG for its interaction with Schwann cells.
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Cited by
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Cole, S. T., Eiglmeier, K., Parkhill, J., James, K. D., Thomson, N. R., Wheeler, P. R., Honoré, N., Garnier, T., Churcher, C., Harris, D., et al. (2001) · Nature · doi:10.1038/35059006 · Cited by 1,777
Deciphering the Glycosylome of Dystroglycanopathies Using Haploid Screens for Lassa Virus Entry
Jae, L. T., Raaben, M., Riemersma, M., van Beusekom, E., Blomen, V. A., Velds, A., Kerkhoven, R. M., Carette, J. E., Topaloglu, H., Meinecke, P., et al. (2013) · Science · doi:10.1126/science.1233675 · Cited by 272
Molecular Recognition by LARGE Is Essential for Expression of Functional Dystroglycan
Kanagawa, M., Saito, F., Kunz, S., Yoshida-Moriguchi, T., Barresi, R., Kobayashi, Y. M., Muschler, J., Dumanski, J. P., Michele, D. E., Oldstone, M. B. A., et al. (2004) · Cell · doi:10.1016/j.cell.2004.06.003 · Cited by 261
Self-citationOn the molecular architecture of myelinated fibers
Arroyo, E. J., & Scherer, S. S. (2000) · Histochemistry and Cell Biology · doi:10.1007/s004180050001 · Cited by 252
The evolution of the dystroglycan complex, a major mediator of muscle integrity
Adams, J. C., & Brancaccio, A. (2015) · Biology Open · doi:10.1242/bio.012468 · Cited by 35
Metadata
- Authors
- Rambukkana, A., Yamada, H., Zanazzi, G., Mathus, T., Salzer, J. L., Yurchenco, P. D., Campbell, K. P., & Fischetti, V. A.
- Venue
- Science
- Published
- 1998-12-11
- Volume
- 282
- Issue
- 5396
- Pages
- 2076-2079
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2008741744
- Cited by
- 233
- References
- 0
- FWCI
- 15.62
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rambukkana, A., Yamada, H., Zanazzi, G., Mathus, T., Salzer, J. L., Yurchenco, P. D., Campbell, K. P., & Fischetti, V. A. (1998). Role of α-Dystroglycan as a Schwann Cell Receptor for Mycobacterium leprae. Science. https://doi.org/10.1126/science.282.5396.2076
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