Cited by 458Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

The Contribution of α2-Noradrenergic Mechanisms to Prefrontal Cortical Cognitive Function: Potential Significance for Attention-Deficit Hyperactivity Disorder

Arnsten, Amy F.T.·1996·Archives of General Psychiatry

Abstract

This article aims to review research in nonhuman primates demonstrating that norepinephrine can enhance the cognitive functioning of the prefrontal cortex through actions at alpha 2 A-adrenergic receptors postjunctional to noradrenergic terminals. As prefrontal cortex cognitive deficits are prominent in several psychiatric disorders, including attention-deficit hyperactivity disorder, these basic findings may have relevance for the development of novel pharmacotherapies.

Integrity signals

Registry

Crossref · 10.1001/archpsyc.1996.01830050084013

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14 of 14 references verified0 citation errors · 0 not checkable

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  • Development of guanfacine's use in ADHD was based on understanding its prefrontal enhancement in monkeys and recognition that ADHD is a PFC disorder.

    “with the development of guanfacine’s use in ADHD based on understanding its prefrontal enhancement in monkeys (Arnsten and Contant, 1992, Arnsten et al., 1996), and the recognition that ADHD is a PFC disorder.”

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Authors
Arnsten, A. F. T.
Affiliations
Yale University (US)
Corresponding author
Arnsten, Amy F.T.
Venue
Archives of General Psychiatry
Published
1996-05-01
Volume
53
Issue
5
Pages
448
ISSN
0003-990X (ISSN-L)
OpenAlex
W2042348492
Cited by
458
References
14
Citations by year
2026: 1 · 2025: 2 · 2024: 5 · 2023: 5 · 2022: 6 · 2021: 8 · 2020: 6 · 2019: 4 · 2018: 5 · 2017: 10 · 2016: 23 · 2015: 13 · 2014: 18 · 2013: 11 · 2012: 21
FWCI
8.58
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG06036)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
alpha2A-adrenergic receptor, norepinephrine, prefrontal cortex, cognitive function, noradrenergic terminals, postjunctional receptors, attention deficit hyperactivity disorder, mental illness, pharmacotherapy
MeSH terms
Adrenergic alpha-Agonists, Animals, Haplorhini, Attention Deficit Disorder with Hyperactivity, Clonidine, Cognition Disorders, Humans, Locus Coeruleus, Models, Neurological, Neural Pathways, Norepinephrine, Guanfacine, Prefrontal Cortex, Receptors, Adrenergic, alpha-2

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