The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium.
Open accessAbstract
The residue involved in sodium regulation of G-protein-coupled receptors has been identified by site-directed mutagenesis of the alpha 2-adrenergic receptor gene. Mutation of Asp-79 to Asn-79 entirely eliminates allosteric regulation of ligand binding by monovalent cations without perturbing the selectivity of adrenergic binding or allosteric modulation of that binding by amiloride analogs. The high degree of conservation of this aspartate residue in all G-protein-coupled receptors, without even a conservative change to glutamate, underscores the probable importance of this allosteric regulation.
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Cites
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Isolation, sequence analysis, and intron-exon arrangement of the gene encoding bovine rhodopsin
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Cited by
Dopamine receptors: from structure to function
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Emerging paradigms in GPCR allostery: implications for drug discovery
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Metadata
- Authors
- Horstman, D. A., Brandon, S., Wilson, A. L., Guyer, C. A., Cragoe, E. J., & Limbird, L. E.
- Venue
- Journal of Biological Chemistry
- Publisher
- Elsevier BV
- Published
- 1990-12
- Volume
- 265
- Issue
- 35
- Pages
- 21590-21595
- ISSN
- 0021-9258 (ISSN-L)
- OpenAlex
- W1539774089
- Cited by
- 271
- References
- 26
- FWCI
- 6.08
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- CoChat. (2026). Citation check: An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium. https://app.cochat.ai/papers/10.1016/s0021-9258(18)45781-x
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- Horstman, D. A., Brandon, S., Wilson, A. L., Guyer, C. A., Cragoe, E. J., & Limbird, L. E. (1990). An aspartate conserved among G-protein receptors confers allosteric regulation of alpha 2-adrenergic receptors by sodium. Journal of Biological Chemistry. https://doi.org/10.1016/s0021-9258(18)45781-x
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
