The DOI matches its Crossref record; 30 of the 30 references it cites were found in a registry or an index.
The Role of Local Actin Instability in Axon Formation
Abstract
The role of localized instability of the actin network in specifying axonal fate was examined with the use of rat hippocampal neurons in culture. During normal neuronal development, actin dynamics and instability polarized to a single growth cone before axon formation. Consistently, global application of actin-depolymerizing drugs and of the Rho-signaling inactivator toxin B to nonpolarized cells produced neurons with multiple axons. Moreover, disruption of the actin network in one individual growth cone induced its neurite to become the axon. Thus, local instability of the actin network restricted to a single growth cone is a physiological signal specifying neuronal polarization.
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Cites
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Cooper, J. A. (1987) · The Journal of cell biology · doi:10.1083/jcb.105.4.1473 · Cited by 2,009
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Self-citationActin-Based Cell Motility and Cell Locomotion
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Glucosylation of Rho proteins by Clostridium difficile toxin B
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Cited by
Microtubule assembly, organization and dynamics in axons and dendrites
Conde, C., & Cáceres, A. (2009) · Nature Reviews Neuroscience · doi:10.1038/nrn2631 · Cited by 1,086
RHO GTPASES in neuronal morphogenesis
Luo, L. (2000) · Nature Reviews Neuroscience · doi:10.1038/35044547 · Cited by 986
Actin Cytoskeleton Regulation in Neuronal Morphogenesis and Structural Plasticity
Luo, L. (2002) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.18.031802.150501 · Cited by 658
Neuronal polarity: from extracellular signals to intracellular mechanisms.
Arimura, N., & Kaibuchi, K. (2007) · Nature Reviews Neuroscience · doi:10.1038/nrn2056 · Cited by 655
Hippocampal Neuronal Polarity Specified by Spatially Localized mPar3/mPar6 and PI 3-Kinase Activity
Shi, S.-H., Jan, L. Y., & Jan, Y.-N. (2003) · Cell · doi:10.1016/s0092-8674(02)01249-7 · Cited by 600
Metadata
- Authors
- Bradke, F., & Dotti, C. G.
- Venue
- Science
- Published
- 1999-03-19
- Volume
- 283
- Issue
- 5409
- Pages
- 1931-1934
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1978679499
- Cited by
- 532
- References
- 30
- FWCI
- 8.82
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
