The DOI matches its Crossref record; 25 of the 25 references it cites were found in a registry or an index.
Requirement of Type III TGF-β Receptor for Endocardial Cell Transformation in the Heart
Abstract
Transforming growth factor–β (TGF-β) signaling is mediated by a complex of type I (TBRI) and type II (TBRII) receptors. The type III receptor (TBRIII) lacks a recognizable signaling domain and has no clearly defined role in TGF-β signaling. Cardiac endothelial cells that undergo epithelial-mesenchymal transformation express TBRIII, and here TBRIII-specific antisera were found to inhibit mesenchyme formation and migration in atrioventricular cushion explants. Misexpression of TBRIII in nontransforming ventricular endothelial cells conferred transformation in response to TGF-β2. These results support a model where TBRIII localizes transformation in the heart and plays an essential, nonredundant role in TGF-β signaling.
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Self-citation
Metadata
- Authors
- Brown, C. B., Boyer, A. S., Runyan, R. B., & Barnett, J. V.
- Venue
- Science
- Published
- 1999-03-26
- Volume
- 283
- Issue
- 5410
- Pages
- 2080-2082
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1971510126
- Cited by
- 383
- References
- 25
- FWCI
- 8.92
- Type
- journal article
- Language
- en
- Open access
- closed
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- Brown, C. B., Boyer, A. S., Runyan, R. B., & Barnett, J. V. (1999). Requirement of Type III TGF-β Receptor for Endocardial Cell Transformation in the Heart. Science. https://doi.org/10.1126/science.283.5410.2080
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
