The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Cancer Exosomes Trigger Fibroblast to Myofibroblast Differentiation
Open accessAbstract
There is a growing interest in the cell–cell communication roles in cancer mediated by secreted vesicles termed exosomes. In this study, we examined whether exosomes produced by cancer cells could transmit information to normal stromal fibroblasts and trigger a cellular response. We found that some cancer-derived exosomes could trigger elevated α-smooth muscle actin expression and other changes consistent with the process of fibroblast differentiation into myofibroblasts. We show that TGF-β is expressed at the exosome surface in association with the transmembrane proteoglycan betaglycan. Although existing in a latent state, this complex was fully functional in eliciting SMAD-dependent signaling. Inhibiting either signaling or betaglycan expression attenuated differentiation. While the kinetics and overall magnitude of the response were similar to that achieved with soluble TGF-β, we identified important qualitative differences unique to the exosomal route of TGF-β delivery, as exemplified by a significant elevation in fibroblast FGF2 production. This hitherto unknown trigger for instigating cellular differentiation in a distinctive manner has major implications for mechanisms underlying cancer-recruited stroma, fibrotic diseases, and wound-healing responses. Cancer Res; 70(23); 9621–30. ©2010 AACR.
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Isolation and Characterization of Exosomes from Cell Culture Supernatants and Biological Fluids
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Self-citationMyofibroblasts and mechano-regulation of connective tissue remodelling
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Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes
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B lymphocytes secrete antigen-presenting vesicles.
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Rab27a and Rab27b control different steps of the exosome secretion pathway
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Non-Smad pathways in TGF-β signaling
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Functional delivery of viral miRNAs via exosomes
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Cited by
The biology , function , and biomedical applications of exosomes
Kalluri, R., & LeBleu, V. S. (2020) · Science · doi:10.1126/science.aau6977 · Cited by 10,770
Biological properties of extracellular vesicles and their physiological functions
Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Peinado, H., Alečković, M., Lavotshkin, S., Matei, I., Costa-Silva, B., Moreno-Bueno, G., Hergueta-Redondo, M., Williams, C., García-Santos, G., Ghajar, C. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2753 · Cited by 3,715
Concepts of extracellular matrix remodelling in tumour progression and metastasis
Winkler, J., Abisoye-Ogunniyan, A., Metcalf, K. J., & Werb, Z. (2020) · Nature Communications · doi:10.1038/s41467-020-18794-x · Cited by 2,296
Exosomes: biogenesis, biologic function and clinical potential
Zhang, Y., Liu, Y., Liu, H., & Tang, W. H. (2019) · Cell & Bioscience · doi:10.1186/s13578-019-0282-2 · Cited by 2,119
Metadata
- Authors
- Webber, J., Steadman, R., Mason, M. D., Tabi, Z., & Clayton, A.
- Venue
- Cancer Research
- Published
- 2010-12-01
- Volume
- 70
- Issue
- 23
- Pages
- 9621-9630
- ISSN
- 0008-5472 (ISSN-L)
- 1538-7445
- OpenAlex
- W2063480251
- Cited by
- 852
- References
- 37
- FWCI
- 8.51
- Type
- journal article
- Language
- en
- Open access
- bronze
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