The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Functional Expression of a New Pharmacological Subtype of Brain Nicotinic Acetylcholine Receptor
Abstract
A new type of agonist-binding subunit of rat neuronal nicotinic acetylcholine receptors (nAChRs) was identified. Rat genomic DNA and complementary DNA encoding this subunit (alpha2) were cloned and analyzed. Complementary DNA expression studies in Xenopus oocytes revealed that the injection of messenger RNAs (mRNAs) for alpha2 and beta2 (a neuronal nAChR subunit) led to the generation of a functional nAChR. In contrast to the other known neuronal nAChRs, the receptor produced by the injection of alpha2 and beta2 mRNAs was resistant to the α-neurotoxin Bgt3.1. In situ hybridization histochemistry showed that alpha2 mRNA was expressed in a small number of regions, in contrast to the wide distribution of the other known agonist-binding subunits (alpha3 and alpha4) mRNAs. These results demonstrate that the alpha2 subunit differs from other known agonist-binding α-subunits of nAChRs in its distribution in the brain and in its pharmacology.
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Cites
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Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family
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Cited by
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Self-citationNicotine binding and nicotinic receptor subunit RNA after chronic nicotine treatment
Marks, M., Pauly, Jr., Gross, S., Deneris, E., Hermans-Borgmeyer, I., Heinemann, S., & Collins, A. (1992) · The Journal of Neuroscience · doi:10.1523/jneurosci.12-07-02765.1992 · Cited by 551
Self-citationRegulation of Class I MHC Gene Expression in the Developing and Mature CNS by Neural Activity
Corriveau, R. A., Huh, G. S., & Shatz, C. J. (1998) · Neuron · doi:10.1016/s0896-6273(00)80562-0 · Cited by 548
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Metadata
- Authors
- Wada, K., Ballivet, M., Boulter, J., Connolly, J., Wada, E., Deneris, E. S., Swanson, L. W., Heinemann, S., & Patrick, J.
- Venue
- Science
- Published
- 1988-04-15
- Volume
- 240
- Issue
- 4850
- Pages
- 330-334
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1986388523
- Cited by
- 310
- References
- 34
- FWCI
- 16.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Functional Expression of a New Pharmacological Subtype of Brain Nicotinic Acetylcholine Receptor. https://app.cochat.ai/papers/10.1126/science.2832952
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- Wada, K., Ballivet, M., Boulter, J., Connolly, J., Wada, E., Deneris, E. S., Swanson, L. W., Heinemann, S., & Patrick, J. (1988). Functional Expression of a New Pharmacological Subtype of Brain Nicotinic Acetylcholine Receptor. Science. https://doi.org/10.1126/science.2832952
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
