The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A Cell's Sense of Direction
Abstract
In eukaryotic cells directional sensing is mediated by heterotrimeric guanine nucleotide–binding protein (G protein)–linked signaling pathways. In Dictyostelium discoideum amoebae and mammalian leukocytes, the receptors and G-protein subunits are uniformly distributed around the cell perimeter. Chemoattractants induce the transient appearance of binding sites for several pleckstrin homology domain–containing proteins on the inner face of the membrane. In gradients of attractant these sites are persistently present on the side of the cell facing the higher concentration, even in the absence of a functional actin cytoskeleton or cell movement. Thus, the cell senses direction by spatially regulating the activity of the signal transduction pathway.
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Cites
Cell Migration: A Physically Integrated Molecular Process
Lauffenburger, D. A., & Horwitz, A. F. (1996) · Cell · doi:10.1016/s0092-8674(00)81280-5 · Cited by 3,915
Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases
Caron, E., & Hall, A. (1998) · Science · doi:10.1126/science.282.5394.1717 · Cited by 1,019
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Exploring and Engineering the Cell Surface Interface
Stevens, M. M., & George, J. H. (2005) · Science · doi:10.1126/science.1106587 · Cited by 2,607
Biomedical surface science: Foundations to frontiers
Castner, D. G., & Ratner, B. D. (2002) · Surface Science · doi:10.1016/s0039-6028(01)01587-4 · Cited by 1,329
Defining Network Topologies that Can Achieve Biochemical Adaptation
Ma, W., Trusina, A., El-Samad, H., Lim, W. A., & Tang, C. (2009) · Cell · doi:10.1016/j.cell.2009.06.013 · Cited by 919
Wang, W., Goswami, S., Lapidus, K., Wells, A. L., Wyckoff, J. B., Sahai, E., Singer, R. H., Segall, J. E., & Condeelis, J. S. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1136 · Cited by 455
Cell migration requires both ion translocation and cytoskeletal anchoring by the Na-H exchanger NHE1
Denker, S. P., & Barber, D. L. (2002) · The Journal of Cell Biology · doi:10.1083/jcb.200208050 · Cited by 432
Metadata
- Authors
- Parent, C. A., & Devreotes, P. N.
- Venue
- Science
- Published
- 1999-04-30
- Volume
- 284
- Issue
- 5415
- Pages
- 765-770
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2024813407
- Cited by
- 890
- References
- 2
- FWCI
- 18.05
- Type
- journal article
- Language
- en
- Open access
- closed
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
