The DOI matches its Crossref record.
DNA Binding by Proteins
Abstract
Study of proteins that recognize specific DNA sequences has yielded much information, but the field is still in its infancy. Already two major structural motifs have been discovered, the helix-turn-helix and zinc finger, and numerous examples of DNA-binding proteins containing either of them are known. The restriction enzyme Eco RI uses yet a different motif. Additional motifs are likely to be found as well. There is a growing understanding of some of the physical chemistry involved in protein-DNA binding, but much remains to be learned before it becomes possible to engineer a protein that binds to a specific DNA sequence.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cited by
Sequence-Selective Recognition of DNA by Strand Displacement with a Thymine-Substituted Polyamide
Nielsen, P. E., Egholm, M., Berg, R. H., & Buchardt, O. (1991) · Science · doi:10.1126/science.1962210 · Cited by 3,332
Specific regulation of gene expression by antisense, sense and antigene nucleic acids
Hélène, C., & Toulmé, J.-J. (1990) · Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · doi:10.1016/0167-4781(90)90031-v · Cited by 768
Synonymous codon usage in Drosophila melanogaster: Natural selection and translational accuracy
Akashi, H. (1994) · Genetics · doi:10.1093/genetics/136.3.927 · Cited by 742
Epstein, D. J., Vekemans, M., & Gros, P. (1991) · Cell · doi:10.1016/0092-8674(91)90071-6 · Cited by 665
The helix-turn-helix DNA binding motif
Brennan, R. G., & Matthews, B. W. (1989) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)94115-3 · Cited by 613
Metadata
- Authors
- Schleif, R.
- Venue
- Science
- Published
- 1988-09-02
- Volume
- 241
- Issue
- 4870
- Pages
- 1182-1187
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2059950836
- Cited by
- 196
- References
- 0
- FWCI
- 11.05
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: DNA Binding by Proteins. https://app.cochat.ai/papers/10.1126/science.2842864
- The paper
- Schleif, R. (1988). DNA Binding by Proteins. Science. https://doi.org/10.1126/science.2842864
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
