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Sarafotoxin, a Novel Vasoconstrictor Peptide: Phosphoinositide Hydrolysis in Rat Heart and Brain
Abstract
Sarafotoxins, a group of 21-residue cardiotoxic peptides from snake venom that induce coronary vasoconstriction, show high-affinity binding to rat atrial and brain membranes and activate the hydrolysis of phosphoinositides. Neither their binding nor their activity is affected by blockers or activators of known receptors and ion channels, suggesting that sarafotoxins act either directly on the phosphoinositide phosphodiesterase system or on a novel receptor. Their amino acid sequence shows a high degree of homology with that of endothelin, a recently described 21-residue vasoconstrictor peptide found in porcine aortic endothelium. This is remarkable, since endothelin is a natural compound of the mammalian vascular system while sarafotoxins are highly toxic components of snake venom.
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Cited by
Davenport, A. P., Hyndman, K. A., Dhaun, N., Southan, C., Kohan, D. E., Pollock, J. S., Pollock, D. M., Webb, D. J., & Maguire, J. J. (2016) · Pharmacological Reviews · doi:10.1124/pr.115.011833 · Cited by 772
Mast Cells Can Enhance Resistance to Snake and Honeybee Venoms
Metz, M., Piliponsky, A. M., Chen, C.-C., Lammel, V., Åbrink, M., Pejler, G., Tsai, M., & Galli, S. J. (2006) · Science · doi:10.1126/science.1128877 · Cited by 319
Schneider, L. A., Schlenner, S. M., Feyerabend, T. B., Wunderlin, M., & Rodewald, H.-R. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071262 · Cited by 145
Mast cells and IgE in defense against venoms: Possible “good side” of allergy?
Galli, S. J., Starkl, P., Marichal, T., & Tsai, M. (2016) · Allergology International · doi:10.1016/j.alit.2015.09.002 · Cited by 73
Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy
Galli, S. J., Metz, M., Starkl, P., Marichal, T., & Tsai, M. (2020) · Allergo Journal International · doi:10.1007/s40629-020-00118-6 · Cited by 57
Metadata
- Authors
- Kloog, Y., Ambar, I., Sokolovsky, M., Kochva, E., Wollberg, Z., & Bdolah, A.
- Venue
- Science
- Published
- 1988-10-14
- Volume
- 242
- Issue
- 4876
- Pages
- 268-270
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1969712064
- Cited by
- 368
- References
- 0
- FWCI
- 23.56
- Type
- journal article
- Language
- en
- Open access
- closed
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- Kloog, Y., Ambar, I., Sokolovsky, M., Kochva, E., Wollberg, Z., & Bdolah, A. (1988). Sarafotoxin, a Novel Vasoconstrictor Peptide: Phosphoinositide Hydrolysis in Rat Heart and Brain. Science. https://doi.org/10.1126/science.2845579
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
