The DOI matches its Crossref record.
Mast Cells Can Enhance Resistance to Snake and Honeybee Venoms
Abstract
Snake or honeybee envenomation can cause substantial morbidity and mortality, and it has been proposed that the activation of mast cells by snake or insect venoms can contribute to these effects. We show, in contrast, that mast cells can significantly reduce snake-venom–induced pathology in mice, at least in part by releasing carboxypeptidase A and possibly other proteases, which can degrade venom components. Mast cells also significantly reduced the morbidity and mortality induced by honeybee venom. These findings identify a new biological function for mast cells in enhancing resistance to the morbidity and mortality induced by animal venoms.
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In the citing paper
“They also mediate protection from venoms produced by a range of animals, including snakes and bees. 5 , 6 , 7”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [5]
In the citing paper
“On the other hand, mast cells can also be protective, for example against Staphylococcus, honeybee, and snake venom. 1 , 5 , 6 , 7”
From Mast cell ontogeny: From fetal development to life‐long health and disease (2023) · cites this paper as [5]
In the citing paper
“Metz et al. showed that mast cells not only diminished the toxicity of sarafotoxin 6b and enhanced the survival of mice injected with that peptide, but also did so in mice injected with the whole venom of A. engaddensis [15].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [15]
In the citing paper
“we will describe evidence that mast cells can enhance innate resistance, and survival, to challenge with reptile or arthropod venoms during a first exposure to such venoms.”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [15]
In the citing paper
“Using mast cell knock-in mice, Metz et al. also provided evidence that mast cells were important in substantially enhancing the innate resistance of mice to honeybee (Apis mellifera) venom and to the venoms of two North American pit vipers, the western diamondback rattlesnake (Crotalus atrox) and the southern copperhead (Agkistrodon contortrix contortrix) [15].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [15]
In the citing paper
“However, later work by our group, employing both pharmacological approaches and shRNA knock down of CPA3 in adoptively-transferred mast cells [15], as well as elegant studies by Schneider et al., who exploited a mouse they created which expressed only a catalytically inactive CPA3 [81], indicated that CPA3 is the key mast cell-derived protease that detoxifies both ET-1 and sarafotoxin 6b.”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [15]
In the citing paper
“The latter finding suggested that mast cells can contribute to IgE-mediated acquired resistance to honeybee venom, as well as enhance the innate resistance of mice to a first exposure to that venom [15].”
From Mast cells and IgE in defense against lethality of venoms: Possible “benefit” of allergy (2020) · cites this paper as [15]
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Cited by
Sorted by citations
Galli, S. J., Borregaard, N., & Wynn, T. A. (2011) · Nature Immunology · doi:10.1038/ni.2109 · Cited by 1,055
Self-citationMast cell tryptases and chymases in inflammation and host defense.
Caughey, G. H. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00509.x · Cited by 442
Widespread Immunological Functions of Mast Cells: Fact or Fiction?
Rodewald, H.-R., & Feyerabend, T. B. (2012) · Immunity · doi:10.1016/j.immuni.2012.07.007 · Cited by 240
Innate Immunity and Its Regulation by Mast Cells
St. John, A. L., & Abraham, S. N. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1203420 · Cited by 220
Mast cells, versatile gatekeepers of pain
Chatterjea, D., & Martinov, T. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2014.03.001 · Cited by 110
Metadata
- Authors
- Metz, M., Piliponsky, A. M., Chen, C.-C., Lammel, V., Åbrink, M., Pejler, G., Tsai, M., & Galli, S. J.
- Affiliations
- Department of Pathology, Stanford University School of Medicine, Stanford, CA 94305–5324, USA.
- Venue
- Science
- Published
- 2006-07-28
- Volume
- 313
- Issue
- 5786
- Pages
- 526-530
- ISSN
- 0036-8075
- 1095-9203
- Cited by
- 319
- References
- 0
- Language
- en
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- The paper
- Metz, M., Piliponsky, A. M., Chen, C.-C., Lammel, V., Åbrink, M., Pejler, G., Tsai, M., & Galli, S. J. (2006). Mast Cells Can Enhance Resistance to Snake and Honeybee Venoms. Science. https://doi.org/10.1126/science.1128877
