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Differences in Left-Right Axis Pathways in Mouse and Chick: Functions of FGF8 and SHH
Abstract
A molecular pathway leading to left-right asymmetry in the chick embryo has been described, in which FGF8 is a right determinant and Sonic Hedgehog a left determinant. Here evidence is presented that the Fgf8 and Sonic Hedgehog genes are required for left-right axis determination in the mouse embryo, but that they have different functions from those previously reported in the chick. In the mouse FGF8 is a left determinant and Sonic Hedgehog is required to prevent left determinants from being expressed on the right.
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Citations
Cited by
Retinoic Acid Synthesis and Signaling during Early Organogenesis
Duester, G. (2008) · Cell · doi:10.1016/j.cell.2008.09.002 · Cited by 1,098
1 Developmental roles and clinical significance of Hedgehog signaling
McMahon, A. P., Ingham, P. W., & Tabin, C. J. (2003) · Current Topics in Developmental Biology · doi:10.1016/s0070-2153(03)53002-2 · Cited by 772
Retinoic acid in development: Towards an integrated view
Niederreither, K., & Dollé, P. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2340 · Cited by 726
Zhang, X. M., Ramalho-Santos, M., & McMahon, A. P. (2001) · Cell · doi:10.1016/s0092-8674(01)00385-3 · Cited by 606
Establishment of vertebrate left–right asymmetry
Hamada, H., Meno, C., Watanabe, D., & Saijoh, Y. (2002) · Nature Reviews Genetics · doi:10.1038/nrg732 · Cited by 489
Metadata
- Authors
- Meyers, E. N., & Martin, G. R.
- Venue
- Science
- Published
- 1999-07-16
- Volume
- 285
- Issue
- 5426
- Pages
- 403-406
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2016882805
- Cited by
- 304
- References
- 0
- FWCI
- 9.13
- Type
- journal article
- Language
- en
- Open access
- closed
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- Meyers, E. N., & Martin, G. R. (1999). Differences in Left-Right Axis Pathways in Mouse and Chick: Functions of FGF8 and SHH. Science. https://doi.org/10.1126/science.285.5426.403
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
