The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Search for Cross-Species Transmission of Porcine Endogenous Retrovirus in Patients Treated with Living Pig Tissue
Abstract
Pig organs may offer a solution to the shortage of human donor organs for transplantation, but concerns remain about possible cross-species transmission of porcine endogenous retrovirus (PERV). Samples were collected from 160 patients who had been treated with various living pig tissues up to 12 years earlier. Reverse transcription–polymerase chain reaction (RT-PCR) and protein immunoblot analyses were performed on serum from all 160 patients. No viremia was detected in any patient. Peripheral blood mononuclear cells from 159 of the patients were analyzed by PCR using PERV-specific primers. No PERV infection was detected in any of the patients from whom sufficient DNA was extracted to allow complete PCR analysis (97 percent of the patients). Persistent microchimerism (presence of donor cells in the recipient) was observed in 23 patients for up to 8.5 years.
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Cites
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Cell migration and chimerism after whole-organ transplantation: The basis of graft acceptance
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Two sets of human-tropic pig retrovirus
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Identification of a Full-Length cDNA for an Endogenous Retrovirus of Miniature Swine
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Cited by
Results of Two Cases of Pig-to-Human Kidney Xenotransplantation
Montgomery, R. A., Stern, J. M., Lonze, B. E., Tatapudi, V. S., Mangiola, M., Wu, M., Weldon, E., Lawson, N., Deterville, C., Dieter, R. A., et al. (2022) · New England Journal of Medicine · doi:10.1056/nejmoa2120238 · Cited by 508
Infection by porcine endogenous retrovirus after islet xenotransplantation in SCID mice
van der Laan, L. J. W., Lockey, C., Griffeth, B. C., Frasier, F. S., Wilson, C. A., Onions, D. E., Hering, B. J., Long, Z., Otto, E., Torbett, B. E., et al. (2000) · Nature · doi:10.1038/35024089 · Cited by 395
Self-citationPrevention of acute liver failure in rats with reversibly immortalized human hepatocytes
Kobayashi, N., Fujiwara, T., Westerman, K. A., Inoue, Y., Sakaguchi, M., Noguchi, H., Miyazaki, M., Cai, J., Tanaka, N., Fox, I. J., et al. (2000) · Science · doi:10.1126/science.287.5456.1258 · Cited by 331
Advances in bioartificial liver devices
Allen, J. W., Hassanein, T., & Bhatia, S. N. (2001) · Hepatology · doi:10.1053/jhep.2001.26753 · Cited by 326
Will the Pig Solve the Transplantation Backlog?
Cooper, D. K. C., Gollackner, B., & Sachs, D. H. (2002) · Annual Review of Medicine · doi:10.1146/annurev.med.53.082901.103900 · Cited by 288
Metadata
- Authors
- Paradis, K., Langford, G., Long, Z., Heneine, W., Sandstrom, P., Switzer, W. M., Chapman, L. E., Lockey, C., Onions, D., The XEN 111 Study Group, & Otto, E.
- Venue
- Science
- Published
- 1999-08-20
- Volume
- 285
- Issue
- 5431
- Pages
- 1236-1241
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2076129653
- Cited by
- 729
- References
- 19
- FWCI
- 79.14
- Type
- journal article
- Language
- en
- Open access
- closed
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- Paradis, K., Langford, G., Long, Z., Heneine, W., Sandstrom, P., Switzer, W. M., Chapman, L. E., Lockey, C., Onions, D., The XEN 111 Study Group, & Otto, E. (1999). Search for Cross-Species Transmission of Porcine Endogenous Retrovirus in Patients Treated with Living Pig Tissue. Science. https://doi.org/10.1126/science.285.5431.1236
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