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Cited by 255

The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.

Identification of a Full-Length cDNA for an Endogenous Retrovirus of Miniature Swine

Open access
Akiyoshi, Donna E., Denaro, Maria, Zhu, Haihong, Greenstein, Julia L., Banerjee, Papia, Fishman, Jay A.·1998·Journal of Virology

Abstract

Endogenous retroviruses of swine are a concern in the use of pig-derived tissues for xenotransplantation into humans. The nucleotide sequence of porcine endogenous retrovirus taken from lymphocytes of miniature swine (PERV-MSL) has been characterized. PERV-MSL is a type C retrovirus of 8,132 bp with the greatest nucleic acid sequence identity to gibbon ape leukemia virus and murine leukemia virus. Constitutive production of PERV-MSL RNA has been detected in normal leukocytes and in multiple organs of swine. The copy numbers of full-length PERV sequences per genome (approximately 8 to 15) vary among swine strains. The open reading frames for gag,pol, and env in PERV-MSL have over 99% amino acid sequence identity to those of Tsukuba-1 retrovirus and are highly homologous to those of endogenous retrovirus of cell line PK15 (PK15-ERV). Most of the differences in the predicted amino acid sequences of PK15-ERV and PERV-MSL are in the SU (cell attach- ment) region of env. The existence of these PERV clones will enable studies of infection by endogenous retroviruses in xenotransplantation.

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Crossref · 10.1128/jvi.72.5.4503-4507.1998

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Metadata

Authors
Akiyoshi, D. E., Denaro, M., Zhu, H., Greenstein, J. L., Banerjee, P., & Fishman, J. A.
Venue
Journal of Virology
Published
1998-05
Volume
72
Issue
5
Pages
4503-4507
ISSN
  • 0022-538X (ISSN-L)
  • 1098-5514
OpenAlex
W2108280026
Cited by
255
References
36
FWCI
27.74
Type
journal article
Language
en
Open access
green

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Akiyoshi, D. E., Denaro, M., Zhu, H., Greenstein, J. L., Banerjee, P., & Fishman, J. A. (1998). Identification of a Full-Length cDNA for an Endogenous Retrovirus of Miniature Swine. Journal of Virology. https://doi.org/10.1128/jvi.72.5.4503-4507.1998

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