The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Type C Retrovirus Released from Porcine Primary Peripheral Blood Mononuclear Cells Infects Human Cells
Open accessAbstract
As part of the evaluation of porcine cells, tissues, and organs intended for transplantation into humans, we investigated the conditions required to induce expression and release of porcine endogenous retrovirus (PoEV) from primary cells. Pigs contain endogenous retroviral sequences encoding infectious retrovirus, yet little is known about the conditions required to activate the expression and release of PoEV from primary cells. We show here that mitogenic activation of peripheral blood mononuclear cells (PBMC) isolated from the National Institutes of Health (NIH) miniature pig and the Yucatan pig resulted in the activation and release of an infectious type C retrovirus. Coculture of activated porcine PBMC with pig or human cell lines resulted in the transfer and expression of PoEV-specific sequences and the establishment of a productive infection. Sequence comparison of portions of the PoEV pol gene expressed in pig cell lines productively infected with virus derived from NIH miniature pig and Yucatan pig PBMC revealed marked similarity, suggesting that one or a few loci may be capable of being activated to yield an infectious virus. These findings demonstrate that the presence of endogenous viruses in source animals needs to be carefully considered when the infectious disease potential of xenotransplantation is being assessed.
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Cites
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Cited by
Dejardin, L. M., Arnoczky, S. P., Ewers, B. J., Haut, R. C., & Clarke, R. B. (2001) · The American Journal of Sports Medicine · doi:10.1177/03635465010290021001 · Cited by 276
Delwart, E. L. (2007) · Reviews in Medical Virology · doi:10.1002/rmv.532 · Cited by 259
Infection Barriers to Successful Xenotransplantation Focusing on Porcine Endogenous Retroviruses
Denner, J., & Tönjes, R. R. (2012) · Clinical Microbiology Reviews · doi:10.1128/cmr.05011-11 · Cited by 208
Metadata
- Authors
- Wilson, C. A., Wong, S., Muller, J., Davidson, C. E., Rose, T. M., & Burd, P.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1998-04
- Volume
- 72
- Issue
- 4
- Pages
- 3082-3087
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W2165500753
- Cited by
- 382
- References
- 19
- FWCI
- 40.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Wilson, C. A., Wong, S., Muller, J., Davidson, C. E., Rose, T. M., & Burd, P. (1998). Type C Retrovirus Released from Porcine Primary Peripheral Blood Mononuclear Cells Infects Human Cells. Journal of Virology. https://doi.org/10.1128/jvi.72.4.3082-3087.1998
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
