The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Acute Activation of Maxi-K Channels ( hSlo ) by Estradiol Binding to the β Subunit
Abstract
Maxi-K channels consist of a pore-forming α subunit and a regulatory β subunit, which confers the channel with a higher Ca 2+ sensitivity. Estradiol bound to the β subunit and activated the Maxi-K channel ( hSlo ) only when both α and β subunits were present. This activation was independent of the generation of intracellular signals and could be triggered by estradiol conjugated to a membrane-impenetrable carrier protein. This study documents the direct interaction of a hormone with a voltage-gated channel subunit and provides the molecular mechanism for the modulation of vascular smooth muscle Maxi-K channels by estrogens.
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Self-citationSpecific binding sites for oestrogen at the outer surfaces of isolated endometrial cells
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SPECIFIC, NONGENOMIC ACTIONS OF STEROID HORMONES
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mSlo , a Complex Mouse Gene Encoding "Maxi" Calcium-Activated Potassium Channels
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Germain, P., Staels, B., Dacquet, C., Spedding, M., & Laudet, V. (2006) · Pharmacological Reviews · doi:10.1124/pr.58.4.2 · Cited by 688
Steroid-hormone rapid actions, membrane receptors and a conformational ensemble model
Norman, A. W., Mizwicki, M. T., & Norman, D. P. G. (2004) · Nature Reviews Drug Discovery · doi:10.1038/nrd1283 · Cited by 569
Nongenomic steroid action: controversies, questions, and answers
LÖSEL, R. M., FALKENSTEIN, E., FEURING, M., SCHULTZ, A., TILLMANN, H.-C., ROSSOL-HASEROTH, K., & WEHLING, M. (2003) · Physiological Reviews · doi:10.1152/physrev.00003.2003 · Cited by 561
Nature of Functional Estrogen Receptors at the Plasma Membrane
Pedram, A., Razandi, M., & Levin, E. R. (2006) · Molecular Endocrinology · doi:10.1210/me.2005-0525 · Cited by 522
Regulation of Amino Acid and Glucose Transporters in Endothelial and Smooth Muscle Cells
Mann, G. E., Yudilevich, D. L., & Sobrevia, L. (2003) · Physiological Reviews · doi:10.1152/physrev.00022.2002 · Cited by 430
Self-citation
Metadata
- Authors
- Valverde, M. A., Rojas, P., Amigo, J., Cosmelli, D., Orio, P., Bahamonde, M. I., Mann, G. E., Vergara, C., & Latorre, R.
- Venue
- Science
- Published
- 1999-09-17
- Volume
- 285
- Issue
- 5435
- Pages
- 1929-1931
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2029489419
- Cited by
- 507
- References
- 34
- FWCI
- 12.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Acute Activation of Maxi-K Channels ( hSlo ) by Estradiol Binding to the β Subunit. https://app.cochat.ai/papers/10.1126/science.285.5435.1929
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- Valverde, M. A., Rojas, P., Amigo, J., Cosmelli, D., Orio, P., Bahamonde, M. I., Mann, G. E., Vergara, C., & Latorre, R. (1999). Acute Activation of Maxi-K Channels ( hSlo ) by Estradiol Binding to the β Subunit. Science. https://doi.org/10.1126/science.285.5435.1929
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
