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Apoptosis of T Cells Mediated by Ca 2+ -Induced Release of the Transcription Factor MEF2
Abstract
T cell receptor (TCR)–induced apoptosis of thymocytes is mediated by calcium-dependent expression of the steroid receptors Nur77 and Nor1. Nur77 expression is controlled by the transcription factor myocyte enhancer factor 2 (MEF2), but how MEF2 is activated by calcium signaling is still obscure. Cabin1, a calcineurin inhibitor, was found to regulate MEF2. MEF2 was normally sequestered by Cabin1 in a transcriptionally inactive state. TCR engagement led to an increase in intracellular calcium concentration and the dissociation of MEF2 from Cabin1, as a result of competitive binding of activated calmodulin to Cabin1. The interplay between Cabin1, MEF2, and calmodulin defines a distinct signaling pathway from the TCR to the Nur77 promoter during T cell apoptosis.
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Citations
Cited by
Dong, X.-X., Wang, Y., & Qin, Z.-H. (2009) · Acta Pharmacologica Sinica · doi:10.1038/aps.2009.24 · Cited by 1,297
MEF2: a central regulator of diverse developmental programs
Potthoff, M. J., & Olson, E. N. (2007) · Development · doi:10.1242/dev.008367 · Cited by 834
Greer, P. L., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.002 · Cited by 661
Class II histone deacetylases: versatile regulators
Verdin, E., Dequiedt, F., & Kasler, H. G. (2003) · Trends in Genetics · doi:10.1016/s0168-9525(03)00073-8 · Cited by 664
Comparative Genome and Proteome Analysis of Anopheles gambiae and Drosophila melanogaster
Zdobnov, E. M., von Mering, C., Letunic, I., Torrents, D., Suyama, M., Copley, R. R., Christophides, G. K., Thomasova, D., Holt, R. A., Subramanian, G. M., et al. (2002) · Science · doi:10.1126/science.1077061 · Cited by 553
Metadata
- Authors
- Youn, H.-D., Sun, L., Prywes, R., & Liu, J. O.
- Venue
- Science
- Published
- 1999-10-22
- Volume
- 286
- Issue
- 5440
- Pages
- 790-793
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2078850134
- Cited by
- 258
- References
- 0
- FWCI
- 8.02
- Type
- journal article
- Language
- en
- Open access
- closed
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- Youn, H.-D., Sun, L., Prywes, R., & Liu, J. O. (1999). Apoptosis of T Cells Mediated by Ca 2+ -Induced Release of the Transcription Factor MEF2. Science. https://doi.org/10.1126/science.286.5440.790
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