Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases

Parkinson's Disease

Dauer, W., & Przedborski, S. (2003) · Neuron · doi:10.1016/s0896-6273(03)00568-3 · Cited by 5,469 · see citing works

Parkinson's Disease

Lang, A. E., & Lozano, A. M. (1998) · New England Journal of Medicine · doi:10.1056/nejm199810083391506 · Cited by 2,041 · see citing works

Apoptosis in the nervous system

Yuan, J., & Yankner, B. A. (2000) · Nature · doi:10.1038/35037739 · Cited by 1,862 · see citing works

Requirement of JNK for Stress- Induced Activation of the Cytochrome c-Mediated Death Pathway

Tournier, C., Hess, P., Yang, D. D., Xu, J., Turner, T. K., Nimnual, A., Bar-Sagi, D., Jones, S. N., Flavell, R. A., & Davis, R. J. (2000) · Science · doi:10.1126/science.288.5467.870 · Cited by 1,728 · see citing works

Selective degradation of mitochondria by mitophagy

Kim, I., Rodriguez-Enriquez, S., & Lemasters, J. J. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.03.034 · Cited by 1,558 · see citing works

Superoxide Anion Radical (O·̄2), Superoxide Dismutases, and Related Matters

Fridovich, I. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.30.18515 · Cited by 1,337 · see citing works

Huntington Disease

Vonsattel, J. P., & DiFiglia, M. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199805000-00001 · Cited by 1,305 · see citing works

Aggregated α‐synuclein activates microglia: a process leading to disease progression in Parkinson's disease

Zhang, W., Wang, T., Pei, Z., Miller, D. S., Wu, X., Block, M. L., Wilson, B., Zhang, W., Zhou, Y., Hong, J.-S., et al. (2005) · The FASEB Journal · doi:10.1096/fj.04-2751com · Cited by 1,265 · see citing works

Lesion of striatal neurons with kainic acid provides a model for Huntington's chorea

Coyle, J. T., & Schwarcz, R. M. (1976) · Nature · doi:10.1038/263244a0 · Cited by 1,255 · see citing works

Ca 2+ -Induced Apoptosis Through Calcineurin Dephosphorylation of BAD

Wang, H., Pathan, N., Ethell, I. M., Krajewski, S., Yamaguchi, Y., Shibasaki, F., McKeon, F., Bobo, T., Franke, T. F., & Reed, J. C. (1999) · Science · doi:10.1126/science.284.5412.339 · Cited by 1,132 · see citing works

Glutamate-mediated excitotoxicity and neurodegeneration in Alzheimer?s disease

HYND, M. (2004) · Neurochemistry International · doi:10.1016/j.neuint.2004.03.007 · Cited by 938 · see citing works

Calpain and caspase: can you tell the difference?

Wang, K. (2000) · Trends in Neurosciences · doi:10.1016/s0166-2236(99)01479-4 · Cited by 912 · see citing works

Aβ Oligomers Induce Neuronal Oxidative Stress through an N-Methyl-D-aspartate Receptor-dependent Mechanism That Is Blocked by the Alzheimer Drug Memantine

De Felice, F. G., Velasco, P. T., Lambert, M. P., Viola, K., Fernandez, S. J., Ferreira, S. T., & Klein, W. L. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607483200 · Cited by 882 · see citing works

Duplication of biochemical changes of Huntington's chorea by intrastriatal injections of glutamic and kainic acids

McGeer, E. G., & McGeer, P. L. (1976) · Nature · doi:10.1038/263517a0 · Cited by 836 · see citing works

Autophagy, amyloidogenesis and Alzheimer disease

Nixon, R. A. (2007) · Journal of Cell Science · doi:10.1242/jcs.019265 · Cited by 749 · see citing works

Apoptosis and increased generation of reactive oxygen species in Down's syndrome neurons in vitro

Busciglio, J., & Yankner, B. A. (1995) · Nature · doi:10.1038/378776a0 · Cited by 741 · see citing works

Dopamine Oxidation Alters Mitochondrial Respiration and Induces Permeability Transition in Brain Mitochondria

Berman, S. B., & Hastings, T. G. (1999) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1999.0731127.x · Cited by 664 · see citing works

The mitochondrial energy transduction system and the aging process

Navarro, A., & Boveris, A. (2007) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00213.2006 · Cited by 646 · see citing works

Antioxidant Therapy in Acute Central Nervous System Injury: Current State

Gilgun-Sherki, Y., Rosenbaum, Z., Melamed, E., & Offen, D. (2002) · Pharmacological Reviews · doi:10.1124/pr.54.2.271 · Cited by 568 · see citing works

Molecular determinants of NMDA receptor internalization

Roche, K. W., Standley, S., McCallum, J., Dune Ly, C., Ehlers, M. D., & Wenthold, R. J. (2001) · Nature Neuroscience · doi:10.1038/90498 · Cited by 550 · see citing works

Oxidative mechanisms in nigral cell death in Parkinson's disease.

Jenner, P. G. (1998) · PubMed · doi:10.1002/mds.870131304 · Cited by 511 · see citing works

Mitochondrial regulation of apoptotic cell death

Orrenius, S. (2004) · Toxicology Letters · doi:10.1016/j.toxlet.2003.12.017 · Cited by 482 · see citing works

Levodopa motor complications in Parkinson's disease

Obeso, J. A., Olanow, C. W., & Nutt, J. G. (2000) · Trends in Neurosciences · doi:10.1016/s1471-1931(00)00031-8 · Cited by 478 · see citing works

Ketones inhibit mitochondrial production of reactive oxygen species production following glutamate excitotoxicity by increasing NADH oxidation

Maalouf, M., Sullivan, P. G., Davis, L. M., Kim, D., & Rho, J. M. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.11.065 · Cited by 477 · see citing works

Inflammatory Neurodegeneration Mediated by Nitric Oxide, Glutamate, and Mitochondria

Brown, G. C., & Bal‐Price, A. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:3:325 · Cited by 461 · see citing works

Alzheimer’s disease pathogenesis and therapeutic interventions

Parihar, M. S., & Hemnani, T. (2004) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2003.12.007 · Cited by 434 · see citing works

Roles of Mitochondria in Health and Disease

Duchen, M. R. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s96 · Cited by 425 · see citing works

N-Methyl-d-aspartate (NMDA) receptor function and excitotoxicity in Huntington's disease

FAN, M., & Raymond, L. A. (2006) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2006.11.003 · Cited by 410 · see citing works

The NMDA receptor antagonist memantine as a symptomatological and neuroprotective treatment for Alzheimer's disease: preclinical evidence

Danysz, W., & Parsons, C. G. (2003) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.938 · Cited by 404 · see citing works

NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress.

Wu, H., & Lozano, G. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32128-2 · Cited by 354 · see citing works

Mitochondria and cell death

Halestrap, A. P., Doran, E., Gillespie, J. P., & O’Toole, A. (2000) · Biochemical Society Transactions · doi:10.1042/bst0280170 · Cited by 320 · see citing works

Crosstalk Between Autophagy and Apoptosis in Heart Disease

Nishida, K., Yamaguchi, O., & Otsu, K. (2008) · Circulation Research · doi:10.1161/circresaha.108.175448 · Cited by 316 · see citing works

Say NO to Alzheimer's disease: the putative links between nitric oxide and dementia of the Alzheimer's type

Law, A. (2001) · Brain Research Reviews · doi:10.1016/s0165-0173(00)00051-5 · Cited by 312 · see citing works

The role of specific ions in glutamate neurotoxicity

Olney, J. W., Price, M. T., Samson, L., & Labruyere, J. (1986) · Neuroscience Letters · doi:10.1016/0304-3940(86)90121-7 · Cited by 297 · see citing works

Polyglutamine-expanded huntingtin promotes sensitization of N-methyl-D-aspartate receptors via post-synaptic density 95

Sun, Y., Savanenin, A., Reddy, P. H., & Liu, Y. F. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m103501200 · Cited by 297 · see citing works

Mitochondrial dysfunction and glutamate excitotoxicity studied in primary neuronal cultures.

Nicholls, D. (2004) · Current molecular medicine · doi:10.2174/1566524043479239 · Cited by 276 · see citing works

Spare Respiratory Capacity Rather Than Oxidative Stress Regulates Glutamate Excitotoxicity after Partial Respiratory Inhibition of Mitochondrial Complex I with Rotenone

Yadava, N., & Nicholls, D. G. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.0212-07.2007 · Cited by 272 · see citing works

Neuroprotection by memantine against neurodegeneration induced by β-amyloid(1–40)

Miguel-Hidalgo, J. J., Alvarez, X. A., Cacabelos, R., & Quack, G. (2002) · Brain Research · doi:10.1016/s0006-8993(02)03731-9 · Cited by 265 · see citing works

Phosphorylation of inositol 1,4,5-trisphosphate receptors by protein kinase B/Akt inhibits Ca 2+ release and apoptosis

Szado, T., Vanderheyden, V., Parys, J. B., SMEDT, H. D., Rietdorf, K., Kotelevets, L., Chastre, E., Khan, F., Landegren, U. D., Söderberg, O., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711324105 · Cited by 262 · see citing works

Apoptosis of T Cells Mediated by Ca 2+ -Induced Release of the Transcription Factor MEF2

Youn, H., Sun, L., Prywes, R., & Liu, J. O. (1999) · Science · doi:10.1126/science.286.5440.790 · Cited by 258 · see citing works

Aging: An important factor for the pathogenesis of neurodegenerative diseases

Farooqui, T., & Farooqui, A. A. (2008) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2008.11.006 · Cited by 244 · see citing works

Amyloid beta peptides and glutamatergic synaptic dysregulation

Parameshwaran, K., Dhanasekaran, M., & Suppiramaniam, V. D. (2007) · Experimental Neurology · doi:10.1016/j.expneurol.2007.10.008 · Cited by 232 · see citing works

Genetically engineered mouse models of neurodegenerative diseases

Wong, P. C., Cai, H., Borchelt, D., & Price, D. L. (2002) · Nature Neuroscience · doi:10.1038/nn0702-633 · Cited by 232 · see citing works

Critical Role of Calpain-mediated Cleavage of Calcineurin in Excitotoxic Neurodegeneration

Wu, H.-Y., Tomizawa, K., Oda, Y., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m309767200 · Cited by 230 · see citing works

Recent advances in the genetics and pathogenesis of Parkinson disease

Mouradian, M. M. (2002) · Neurology · doi:10.1212/wnl.58.2.179 · Cited by 227 · see citing works

Astrocytes regulate GluR2 expression in motor neurons and their vulnerability to excitotoxicity

Damme, P. V., Bogaert, E., Dewil, M., Hersmus, N., Kiraly, D., Scheveneels, W., Bockx, I., Braeken, D., Verpoorten, N., Verhoeven, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705046104 · Cited by 216 · see citing works

Nuclear Factor κB Nuclear Translocation Upregulates c-Myc and p53 Expression during NMDA Receptor-Mediated Apoptosis in Rat Striatum

Qin, Z., Chen, R., Wang, Y., Nakai, M., Chuang, D., & Chase, T. N. (1999) · Journal of Neuroscience · doi:10.1523/jneurosci.19-10-04023.1999 · Cited by 211 · see citing works

Mutant Huntingtin Enhances Excitotoxic Cell Death

Zeron, M. M., Chen, N., Moshaver, A., Lee, A. T. C., Wellington, C. L., Hayden, M. R., & Raymond, L. A. (2001) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0909 · Cited by 197 · see citing works

Ca 2+ signals and death programmes in neurons

Berliocchi, L., Bano, D., & Nicotera, P. (2005) · Philosophical Transactions of the Royal Society B Biological Sciences · doi:10.1098/rstb.2005.1765 · Cited by 174 · see citing works

Loss of wild-type huntingtin influences motor dysfunction and survival in the YAC128 mouse model of Huntington disease

Raamsdonk, J. M. V., Pearson, J., Rogers, D. A., et al. (2005) · Human Molecular Genetics · doi:10.1093/hmg/ddi147 · Cited by 174 · see citing works

Excitotoxicity hypothesis

Rothstein, J. D. (1996) · Neurology · doi:10.1212/wnl.47.4_suppl_2.19s · Cited by 172 · see citing works

Role of Rel-related factors in control of c-myc gene transcription in receptor-mediated apoptosis of the murine B cell WEHI 231 line.

Lee, H., Arsura, M., Wu, M., et al. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.181.3.1169 · Cited by 164 · see citing works

Nuclear Factor-κB Contributes to Excitotoxin-Induced Apoptosis in Rat Striatum

Qin, Z., Wang, Y., Nakai, M., & Chase, T. N. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.1.33 · Cited by 163 · see citing works

The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage

Aleyasin, H., Rousseaux, M. W. C., Phillips, M., Kim, R. H., Bland, R. J., Callaghan, S. M., Slack, R. S., During, M. J., Mak, T. W., & Park, D. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709379104 · Cited by 160 · see citing works

Aβ as a bioflocculant: implications for the amyloid hypothesis of Alzheimer’s disease

Robinson, S. R., & Bishop, G. M. (2002) · Neurobiology of Aging · doi:10.1016/s0197-4580(01)00342-6 · Cited by 153 · see citing works

Na-K-Cl Cotransporter Contributes to Glutamate-Mediated Excitotoxicity

Beck, J., Lenart, B. A., Kintner, D. B., & Sun, D. (2003) · Journal of Neuroscience · doi:10.1523/jneurosci.23-12-05061.2003 · Cited by 146 · see citing works

An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid

Wang, Y., Han, R., Zhong-qin, L., Wu, J.-C., Zhang, X., Gu, Z.-L., & Qin, Z.-H. (2008) · Autophagy · doi:10.4161/auto.5369 · Cited by 134 · see citing works

Pruning and loss of excitatory synapses by the parkin ubiquitin ligase

Helton, T. D., Otsuka, T., Lee, M.-C., Mu, Y., & Ehlers, M. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0802280105 · Cited by 127 · see citing works

Full length mutant huntingtin is required for altered Ca2+ signaling and apoptosis of striatal neurons in the YAC mouse model of Huntington's disease

Zhang, H., Li, Q., Graham, R. K., Slow, E., Hayden, M. R., & Борисович, Б. И. (2008) · Neurobiology of Disease · doi:10.1016/j.nbd.2008.03.010 · Cited by 123 · see citing works

Intrastriatal Dopamine Injection Induces Apoptosis Through Oxidation-Involved Activation of Transcription Factors AP-1 and NF-κB in Rats

Luo, Y., Hattori, A., Munoz, J. R., Qin, Z.-H., & Roth, G. S. (1999) · Molecular Pharmacology · doi:10.1124/mol.56.2.254 · Cited by 120 · see citing works

Nitric oxide mediates neurodegeneration and breakdown of the blood-brain barrier in tPA-dependent excitotoxic injury in mice

Parathath, S. R., Parathath, S., & Tsirka, S. E. (2006) · Journal of Cell Science · doi:10.1242/jcs.02734 · Cited by 111 · see citing works

NF-kappa B-like factors mediate interleukin 1 induction of c-myc gene transcription in fibroblasts.

Kessler, D. J., Duyao, M. P., Spicer, D. B., et al. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.3.787 · Cited by 110 · see citing works

Kainic Acid‐Induced Apoptosis in Rat Striatum Is Associated with Nuclear Factor‐κB Activation

Nakai, M., Qin, Z., Chen, J., Wang, Y., & Chase, T. N. (2000) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2000.740647.x · Cited by 104 · see citing works

A “Protease Activation Cascade” in the Pathogenesis of Alzheimer's Disease

Nixon, R. A. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb05570.x · Cited by 102 · see citing works

Coenzyme Q10 Provides Neuroprotection in Iron-Induced Apoptosis in Dopaminergic Neurons

Kooncumchoo, P., SHARMA, S. K., Porter, J. E., Govitrapong, P., & Ebadi, M. (2006) · Journal of Molecular Neuroscience · doi:10.1385/jmn:28:2:125 · Cited by 100 · see citing works

Lipid Rafts and Oxidative Stress–Induced Cell Death

Morgan, M. J., Kim, Y., & Liu, Z.-G. (2007) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.1658 · Cited by 99 · see citing works

Neurodegenerative disorders: Parkinson's disease and Huntington's disease

Hague, S. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.060186 · Cited by 97 · see citing works

Expression of Polyglutamine-expanded Huntingtin Induces Tyrosine Phosphorylation of N-Methyl-D-aspartate Receptors

Song, C., Zhang, Y., Parsons, C. G., & Liu, Y. F. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m304240200 · Cited by 97 · see citing works

Biochemical changes associated with selective neuronal death following short-term cerebral ischaemia

Sims, N. R., & Zaidan, E. (1995) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/1357-2725(95)00026-l · Cited by 94 · see citing works

RCAN1 (DSCR1) increases neuronal susceptibility to oxidative stress: a potential pathogenic process in neurodegeneration

Porta, S., Serra, S. A., Huch, M., et al. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm049 · Cited by 93 · see citing works

Dual roles of NF-κB in cell survival and implications of NF-κB inhibitors in neuroprotective therapy

Qin, Z., Tao, L., & Chen, X. (2007) · Acta Pharmacologica Sinica · doi:10.1111/j.1745-7254.2007.00741.x · Cited by 92 · see citing works

Further Evidence for Mitochondrial Dysfunction in Progressive Supranuclear Palsy

Albers, D. S., Swerdlow, R. H., Manfredi, G., Gajewski, C. D., Yang, L., Parker, W. D., & Beal, M. F. (2001) · Experimental Neurology · doi:10.1006/exnr.2000.7607 · Cited by 72 · see citing works

The role of excitatory amino acids in neuropsychiatric illness

Javitt, D. C., & Zukin, S. R. (1990) · Journal of Neuropsychiatry · doi:10.1176/jnp.2.1.44 · Cited by 71 · see citing works

Role of N-methyl-D-aspartate receptors in polychlorinated biphenyl mediated neurotoxicity

Ndountse, L. T., & Chan, H. M. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2008.10.013 · Cited by 65 · see citing works

Contributions of autophagic and apoptotic mechanisms to CrTX-induced death of K562 cells

Yan, C., Liang, Z., Gu, Z., Yang, Y., Reid, P. F., & Qin, Z. (2006) · Toxicon · doi:10.1016/j.toxicon.2006.01.010 · Cited by 64 · see citing works

Denbinobin induces apoptosis in human lung adenocarcinoma cells via Akt inactivation, Bad activation, and mitochondrial dysfunction

Kuo, C.-T., Hsu, M.-J., Chen, B.-C., Chen, C.-C., Teng, C.-M., Pan, S.-L., & Lin, C.-H. (2008) · Toxicology Letters · doi:10.1016/j.toxlet.2007.12.009 · Cited by 62 · see citing works

Ca2+-Independent Excitotoxic Neurodegeneration in Isolated Retina, an Intact Neural Net: A Role for Cl− and Inhibitory Transmitters

Chen, Q., Olney, J. W., Lukasiewicz, P. D., Almli, T., & Romano, C. (1998) · Molecular Pharmacology · doi:10.1124/mol.53.3.564 · Cited by 60 · see citing works

A Novel Antioxidant Function for the Tumor-Suppressor Gene p53 in the Retinal Ganglion Cell

O'Connor, J. C., Wallace, D., O'Brien, C. J., & Cotter, T. G. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1963 · Cited by 60 · see citing works

Optical Imaging of Hippocampal Neurons with a Chloride‐Sensitive Dye: Early Effects of In Vitro Ischemia

Inglefield, J. R., & Schwartz‐Bloom, R. D. (1998) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1998.70062500.x · Cited by 59 · see citing works

CALCIUM: A Role for Neuroproduction and Sustained Adaptation

Friedman, L. K. (2006) · Molecular Interventions · doi:10.1124/mi.6.6.5 · Cited by 53 · see citing works

Pharmaceutical, cellular and genetic therapies for Huntington's disease

Handley, O., Naji, J. J., Dunnett, S. B., & Rosser, A. (2005) · Clinical Science · doi:10.1042/cs20050148 · Cited by 51 · see citing works

Augmentation of nitrite therapy in cerebral ischemia by NMDA receptor inhibition

Jung, K., Chu, K., Lee, S., Park, H.-K., Kim, J.-H., Kang, K., Kim, M., Lee, S. K., & Roh, J. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2008.11.081 · Cited by 48 · see citing works

Psychopathology and autobiographical memory in stroke and non‐stroke hospitalized patients

Sampson, M., Kinderman, P., Watts, S., & Sembi, S. (2002) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.763 · Cited by 46 · see citing works

The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival

Lee, H., Zhu, X., Casadesús, G., Pallàs, M., Camins, A., O'Neill, M. J., Nakanishi, S., Perry, G. L., & Smith, M. A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.055 · Cited by 43 · see citing works

Nitric oxide and MPP+-induced hydroxyl radical generation

Obata, T. (2006) · Journal of Neural Transmission · doi:10.1007/s00702-005-0415-0 · Cited by 43 · see citing works

Dual roles of NF-KB in cell survival and implications of NF-KB inhibitors in neuroprotective therapy

Zhenghong, Qin, L., Luyang, Tao, T., Xin, & Chen (2007) · 中国药理学报：英文版 · Cited by 41 · see citing works

Co-stimulation of cyclic-AMP-linked metabotropic glutamate receptors in rat striatum attenuates excitotoxin-induced nuclear factor-κB activation and apoptosis

Wang, Y., Qin, Z., Nakai, M., Chen, R.-W., Chuang, D. M., & Chase, T. N. (1999) · Neuroscience · doi:10.1016/s0306-4522(99)00264-x · Cited by 34 · see citing works

Lysosomal enzyme cathepsin B is involved in kainic acid-induced excitotoxicity in rat striatum

Wang, Y., Gu, Z., Cao, Y., Liang, Z., Han, R., Bennett, M. C., & Qin, Z. (2006) · Brain Research · doi:10.1016/j.brainres.2005.10.074 · Cited by 33 · see citing works

Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity.

Liang, Z.-Q., Wang, X., Wang, Y.-M., Chuang, D. M., DiFiglia, M., Chase, T., & Qin, Z.-H. (2005) · Neurobiology of Disease · doi:10.1016/j.nbd.2005.04.011 · Cited by 31 · see citing works

Effects of KR-33028, a novel Na+/H+ exchanger-1 inhibitor, on glutamate-induced neuronal cell death and ischemia-induced cerebral infarct

Lee, B. K., Lee, D. H., Park, S., et al. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.061 · Cited by 30 · see citing works

Nuclear factor‐κB‐dependent cyclin D1 induction and DNA replication associated with N‐methyl‐D‐aspartate receptor‐mediated apoptosis in rat striatum

Liang, Z., Wang, X., Li, L., et al. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21248 · Cited by 27 · see citing works

Treatment of Vasogenic Brain Edema with the Novel Cl − Transport Inhibitor Torasemide

Staub, F., Stoffel, M. H., Berger, S., et al. (1994) · Journal of Neurotrauma · doi:10.1089/neu.1994.11.679 · Cited by 22 · see citing works

Enhancement of inhibitory synaptic transmission in large aspiny neurons after transient cerebral ischemia

Li, Y., Lei, Z., & Xu, Z. C. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2008.12.046 · Cited by 20 · see citing works

Inhibition of I h in Striatal Cholinergic Interneurons Early after Transient Forebrain Ischemia

Deng, P., Zhang, Y., & Xu, Z. C. (2007) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600583 · Cited by 17 · see citing works

Ca2+‐independent, but voltage‐ and activity‐dependent regulation of the NMDA receptor outward K+ current in mouse cortical neurons

Ichinose, T., Yu, S., Yu, S., et al. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.041723 · Cited by 17 · see citing works

Interaction of the NMDA receptor noncompetitive antagonist MK-801 with model and native membranes

Moring, J., Niego, L. A., Ganley-Leal, L. M., Trumbore, M. W., & Herbette, L. G. (1994) · Biophysical Journal · doi:10.1016/s0006-3495(94)80724-6 · Cited by 16 · see citing works

Selective apoptosis induction in the hippocampal mossy fiber pathway by exposure to CT105, the C-terminal fragment of Alzheimer's amyloid precursor protein

Jinno, S., Araki, K., Matsumoto, Y., Suh, Y., & Yamamoto, T. (2008) · Brain Research · doi:10.1016/j.brainres.2008.10.052 · Cited by 7 · see citing works

Matrix metalloproteinases and nervous diseases

Zhang, H. (2007) · Zhongguo yaolixue tongbao · Cited by 1 · see citing works

Function and therapeutic value of astrocytes in neurological diseases

Lee, H.-G., Wheeler, M. A., & Quintana, F. J. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00390-x · Cited by 662 · see citing works

A Molecular Web: Endoplasmic Reticulum Stress, Inflammation, and Oxidative Stress

Chaudhari, N., Talwar, P., Parimisetty, A., Lefebvre d’Hellencourt, C., & Ravanan, P. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00213 · Cited by 600 · see citing works

The Therapeutic Potential of Anthocyanins: Current Approaches Based on Their Molecular Mechanism of Action

Salehi, B., Sharifi-Rad, J., Cappellini, F., Reiner, Ž., Zorzan, D., Imran, M., Sener, B., Kilic, M., El-Shazly, M., Fahmy, N. M., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.01300 · Cited by 293 · see citing works

The olfactory bulb as the entry site for prion-like propagation in neurodegenerative diseases

Rey, N. L., Wesson, D. W., & Brundin, P. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.12.013 · Cited by 257 · see citing works

Brain glutamate levels measured by magnetic resonance spectroscopy in patients with bipolar disorder: a meta-analysis.

Gigante, A. D., Bond, D. J., Lafer, B., Lam, R. W., Young, L. T., & Yatham, L. N. (2012) · Bipolar Disorders · doi:10.1111/j.1399-5618.2012.01033.x · Cited by 226 · see citing works

Neuronal damage and protection in the pathophysiology and treatment of psychiatric illness: stress and depression

Duman, R. S. (2009) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2009.11.3/rsduman · Cited by 210 · see citing works

Nuclear Tau and Its Potential Role in Alzheimer’s Disease

Bukar Maina, M., Al-Hilaly, Y., & Serpell, L. (2016) · Biomolecules · doi:10.3390/biom6010009 · Cited by 161 · see citing works

Neuropharmacological Effects of Quercetin: A Literature-Based Review

Islam, M. S., Quispe, C., Hossain, R., Islam, M. T., Al-Harrasi, A., Al-Rawahi, A., Martorell, M., Mamurova, A., Seilkhan, A., Altybaeva, N., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.665031 · Cited by 165 · see citing works

Neuroinflammation as an etiological trigger for depression comorbid with inflammatory bowel disease

Craig, C. F., Filippone, R. T., Stavely, R., Bornstein, J. C., Apostolopoulos, V., & Nurgali, K. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02354-1 · Cited by 124 · see citing works

Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration

Gómez de San José, N., Massa, F., Halbgebauer, S., Oeckl, P., Steinacker, P., & Otto, M. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-021-02411-2 · Cited by 112 · see citing works

Human iPSC-derived neuronal model of Tau-A152T frontotemporal dementia reveals tau-mediated mechanisms of neuronal vulnerability

Silva, M. C., Cheng, C., Mair, W., Almeida, S., Fong, H., Biswas, M. H. U., Zhang, Z., Huang, Y., Temple, S., Coppola, G., et al. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.08.001 · Cited by 103 · see citing works

Maternal inflammation leads to impaired glutamate homeostasis and up-regulation of glutamate carboxypeptidase II in activated microglia in the fetal/newborn rabbit brain

Zhang, Z., Bassam, B., Thomas, A. G., Williams, M., Liu, J., Nance, E., Rojas, C., Slusher, B. S., & Kannan, S. (2016) · Neurobiology of Disease · doi:10.1016/j.nbd.2016.06.010 · Cited by 84 · see citing works

Water extract from the leaves of Withania somnifera protect RA differentiated C6 and IMR-32 cells against glutamate-induced excitotoxicity

Kataria, H., Wadhwa, R., Kaul, S. C., & Kaur, G. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037080 · Cited by 77 · see citing works

Potential Role of Natural Polyphenols against Protein Aggregation Toxicity: In Vitro, In Vivo, and Clinical Studies

Henríquez, G., Gomez, A., Guerrero, E., & Narayan, M. (2020) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.0c00381 · Cited by 83 · see citing works

Microglia activation contributes to quinolinic acid-induced neuronal excitotoxicity through TNF-α

Feng, W., Wang, Y., Liu, Z.-Q., Zhang, X., Han, R., Miao, Y.-Z., & Qin, Z.-H. (2017) · Apoptosis · doi:10.1007/s10495-017-1363-5 · Cited by 53 · see citing works

CSF1R inhibitors induce a sex-specific resilient microglial phenotype and functional rescue in a tauopathy mouse model

Johnson, N. R., Yuan, P., Castillo, E., Lopez, T. P., Yue, W., Bond, A., Rivera, B. M., Sullivan, M. C., Hirouchi, M., Giles, K., et al. (2023) · Nature Communications · doi:10.1038/s41467-022-35753-w · Cited by 46 · see citing works

Unified theory of Alzheimer’s disease (UTAD): implications for prevention and curative therapy

Nehls, M. (2016) · Journal of Molecular Psychiatry · doi:10.1186/s40303-016-0018-8 · Cited by 41 · see citing works

Analysis of synaptic gene expression in the neocortex of primates reveals evolutionary changes in glutamatergic neurotransmission

Muntané, G., Horvath, J. E., Hof, P. R., Ely, J. J., Hopkins, W. D., Raghanti, M. A., Lewandowski, A. H., Wray, G. A., & Sherwood, C. C. (2015) · Cerebral Cortex · doi:10.1093/cercor/bht354 · Cited by 36 · see citing works

Chronic Caffeine Exposure Attenuates Blast-Induced Memory Deficit in Mice

Ning, Y.-L., Yang, N., Chen, X., Zhao, Z.-A., Zhang, X.-Z., Chen, X.-Y., Li, P., Zhao, Y., & Zhou, Y.-G. (2015) · Chinese Journal of Traumatology · doi:10.1016/j.cjtee.2015.10.003 · Cited by 24 · see citing works

Predictors of response to repeated ketamine infusions in depression with suicidal ideation: An ROC curve analysis

Zhou, Y., Liu, W., Zheng, W., Wang, C., Zhan, Y., Lan, X., Zhang, B., Zhang, C., & Ning, Y. (2020) · Journal of Affective Disorders · doi:10.1016/j.jad.2020.01.001 · Cited by 23 · see citing works

Discrimination exposure impacts unhealthy processing of food cues: Crosstalk between the brain and gut

Zhang, X., Wang, H., Kilpatrick, L. A., Dong, T. S., Gee, G. C., Labus, J. S., Osadchiy, V., Beltran-Sanchez, H., Wang, M. C., Vaughan, A., et al. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00134-9 · Cited by 20 · see citing works

A compound CP-31398 suppresses excitotoxicity-induced neurodegeneration

Fujiwara, T., & Morimoto, K. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.08.052 · Cited by 5 · see citing works

Neuroprotective Effects of Daphnetin against NMDA Receptor-Mediated Excitotoxicity

Yang, L., Yang, Q., Zhang, K., Li, Y., Wu, Y., Liu, S., Zheng, L., & Zhao, M. (2014) · Molecules · doi:10.3390/molecules190914542 · Cited by 36 · see citing works

Review paper Neurogenesis and neuroprotection in postischemic brain neurodegeneration with Alzheimer phenotype: is there a role for curcumin?

Pluta, R., Bogucka-Kocka, A., Ułamek-Kozioł, M., Furmaga-Jabłońska, W., Januszewski, S., Brzozowska, J., Jabłoński, M., & Kocki, J. (2015) · Folia Neuropathologica · doi:10.5114/fn.2015.52405 · Cited by 34 · see citing works

Pharmacological strategies related to ocular neuroprotection

Garhöfer, G. (2013) · Acta Ophthalmologica · doi:10.1111/j.1755-3768.2013.1641.x

Excitotoxicity‐induced endocytosis mediates neuroprotection by TAT‐peptide‐linked JNK inhibitor

Vaslin, A., Naegele‐Tollardo, S., Puyal, J., et al. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07535.x · Cited by 20 · see citing works