The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Increased Cortical Oxidative Metabolism Due to Sensory Stimulation: Implications for Functional Brain Imaging
Abstract
Modern functional brain mapping relies on interactions of neuronal electrical activity with the cortical microcirculation. The existence of a highly localized, stimulus-evoked initial deoxygenation has remained a controversy. Here, the activity-dependent oxygen tension changes in the microcirculation were measured directly, using oxygen-dependent phosphorescence quenching of an exogenous indicator. The first event after sensory stimulation was an increase in oxygen consumption, followed by an increase in blood flow. Because oxygen consumption and neuronal activity are colocalized but the delayed blood flow is not, functional magnetic resonance imaging focused on this initial phase will yield much higher spatial resolution, ultimately enabling the noninvasive visualization of fundamental processing modules in the human brain.
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Cites
Dynamic magnetic resonance imaging of human brain activity during primary sensory stimulation.
Kwong, K. K., Belliveau, J. W., Chesler, D. A., Goldberg, I. E., Weisskoff, R. M., Poncelet, B. P., Kennedy, D. N., Hoppel, B. E., Cohen, M. S., & Turner, R. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.12.5675 · Cited by 4,212
Functional mapping of the human visual cortex by magnetic resonance imaging
Belliveau, J. W., Kennedy, D. N., McKinstry, R. C., Buchbinder, B. R., Weisskoff, R. M., Cohen, M. S., Vevea, J. M., Brady, T. J., & Rosen, B. R. (1991) · Science · doi:10.1126/science.1948051 · Cited by 1,883
Nonoxidative Glucose Consumption During Focal Physiologic Neural Activity
Fox, P. T., Raichle, M. E., Mintun, M. A., & Dence, C. (1988) · Science · doi:10.1126/science.3260686 · Cited by 1,796
Kleinfeld, D., Mitra, P. P., Helmchen, F., & Denk, W. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.26.15741 · Cited by 832
RELATION BETWEEN PHYSIOLOGICAL FUNCTION AND ENERGY METABOLISM IN THE CENTRAL NERVOUS SYSTEM
Sokoloff, L. (1977) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1977.tb03919.x · Cited by 807
Mapping human visual cortex with positron emission tomography
Fox, P. T., Mintun, M. A., Raichle, M. E., Miezin, F. M., Allman, J. M., & Van Essen, D. C. (1986) · Nature · doi:10.1038/323806a0 · Cited by 422
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Neurovascular regulation in the normal brain and in Alzheimer's disease
Iadecola, C. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1387 · Cited by 2,213
Shedding light onto live molecular targets
Weissleder, R., & Ntziachristos, V. (2003) · Nature Medicine · doi:10.1038/nm0103-123 · Cited by 1,909
Raichle, M. E., & Mintun, M. A. (2006) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.29.051605.112819 · Cited by 1,630
What does fMRI tell us about neuronal activity?
Heeger, D. J., & Ress, D. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn730 · Cited by 1,085
Beyond the Visible???Imaging the Human Brain With Light
Obrig, H., & Villringer, A. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200301000-00001 · Cited by 892
Metadata
- Authors
- Vanzetta, I., & Grinvald, A.
- Venue
- Science
- Published
- 1999-11-19
- Volume
- 286
- Issue
- 5444
- Pages
- 1555-1558
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2030364645
- Cited by
- 319
- References
- 6
- FWCI
- 22.79
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
