The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Mechanism-Based Target Identification and Drug Discovery in Cancer Research
Abstract
Cancer as a disease in the human population is becoming a larger health problem, and the medicines used as treatments have clear limitations. In the past 20 years, there has been a tremendous increase in our knowledge of the molecular mechanisms and pathophysiology of human cancer. Many of these mechanisms have been exploited as new targets for drug development in the hope that they will have greater antitumor activity with less toxicity to the patient than is seen with currently used medicines. The fruition of these efforts in the clinic is just now being realized with a few encouraging results.
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Cites
Sherr, C. J. (1996) · Science · doi:10.1126/science.274.5293.1672 · Cited by 5,379
Herbert, B.-S., Pitts, A. E., Baker, S. I., Hamilton, S. E., Wright, W. E., Shay, J. W., & Corey, D. R. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.25.14276 · Cited by 539
For Better or Worse? Telomerase Inhibition and Cancer
de Lange, T., & Jacks, T. (1999) · Cell · doi:10.1016/s0092-8674(00)81955-8 · Cited by 119
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Kitano, H. (2002) · Science · doi:10.1126/science.1069492 · Cited by 4,265
Proliferation, cell cycle and apoptosis in cancer
Evan, G. I., & Vousden, K. H. (2001) · Nature · doi:10.1038/35077213 · Cited by 2,724
The STATs of cancer — new molecular targets come of age
Yu, H., & Jove, R. (2004) · Nature Reviews Cancer · doi:10.1038/nrc1275 · Cited by 2,278
The role of natural product chemistry in drug discovery
Butler, M. S. (2004) · Journal of Natural Products · doi:10.1021/np040106y · Cited by 1,381
Transcription factors as targets for cancer therapy
Darnell, J. E. (2002) · Nature Reviews Cancer · doi:10.1038/nrc906 · Cited by 1,194
Metadata
- Authors
- Gibbs, J. B.
- Venue
- Science
- Published
- 2000-03-17
- Volume
- 287
- Issue
- 5460
- Pages
- 1969-1973
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2000196730
- Cited by
- 606
- References
- 3
- FWCI
- 29.50
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
