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Structure of the RNA Polymerase Domain of E. coli Primase
Abstract
All cellular organisms use specialized RNA polymerases called “primases” to synthesize RNA primers for the initiation of DNA replication. The high-resolution crystal structure of a primase, comprising the catalytic core of the Escherichia coli DnaG protein, was determined. The core structure contains an active-site architecture that is unrelated to other DNA or RNA polymerase palm folds, but is instead related to the “toprim” fold. On the basis of the structure, it is likely that DnaG binds nucleic acid in a groove clustered with invariant residues and that DnaG is positioned within the replisome to accept single-stranded DNA directly from the replicative helicase.
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Cites
Protein Structure Comparison by Alignment of Distance Matrices
Holm, L., & Sander, C. (1993) · Journal of Molecular Biology · doi:10.1006/jmbi.1993.1489 · Cited by 3,984
DNA Polymerases: Structural Diversity and Common Mechanisms
Steitz, T. A. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.25.17395 · Cited by 848
Cited by
Nucleases: diversity of structure, function and mechanism
Yang, W. (2011) · Quarterly Reviews of Biophysics · doi:10.1017/s0033583510000181 · Cited by 692
RNA-Dependent RNA Polymerases, Viruses, and RNA Silencing
Ahlquist, P. (2002) · Science · doi:10.1126/science.1069132 · Cited by 462
On the origin of genomes and cells within inorganic compartments
Koonin, E. V., & Martin, W. (2005) · Trends in Genetics · doi:10.1016/j.tig.2005.09.006 · Cited by 406
The origin of DNA genomes and DNA replication proteins
Forterre, P. (2002) · Current Opinion in Microbiology · doi:10.1016/s1369-5274(02)00360-0 · Cited by 190
Trends in protein evolution inferred from sequence and structure analysis
Aravind, L., Mazumder, R., Vasudevan, S., & Koonin, E. V. (2002) · Current Opinion in Structural Biology · doi:10.1016/s0959-440x(02)00334-2 · Cited by 148
Metadata
- Authors
- Keck, J. L., Roche, D. D., Lynch, A. S., & Berger, J. M.
- Venue
- Science
- Published
- 2000-03-31
- Volume
- 287
- Issue
- 5462
- Pages
- 2482-2486
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2065857906
- Cited by
- 161
- References
- 2
- FWCI
- 14.16
- Type
- journal article
- Language
- en
- Open access
- closed
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- Keck, J. L., Roche, D. D., Lynch, A. S., & Berger, J. M. (2000). Structure of the RNA Polymerase Domain of E. coli Primase. Science. https://doi.org/10.1126/science.287.5462.2482
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
