The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Regulation of Area Identity in the Mammalian Neocortex by Emx2 and Pax6
Abstract
The contribution of extrinsic and genetic mechanisms in determining areas of the mammalian neocortex has been a contested issue. This study analyzes the roles of the regulatory genes Emx2 and Pax6 , which are expressed in opposing gradients in the neocortical ventricular zone, in specifying areas. Changes in the patterning of molecular markers and area-specific connections between the cortex and thalamus suggest that arealization of the neocortex is disproportionately altered in Emx2 and Pax6 mutant mice in opposing manners predicted from their countergradients of expression: rostral areas expand and caudal areas contract in Emx2 mutants, whereas the opposite effect is seen in Pax6 mutants. These findings suggest that Emx2 and Pax6 cooperate to regulate arealization of the neocortex and to confer area identity to cortical cells.
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Cites
Specification of Cerebral Cortical Areas
Rakic, P. (1988) · Science · doi:10.1126/science.3291116 · Cited by 3,127
Do cortical areas emerge from a protocortex?
O'Leary, D. D. M. (1989) · Trends in Neurosciences · doi:10.1016/0166-2236(89)90080-5 · Cited by 536
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Cited by
The basics of brain development
Stiles, J., & Jernigan, T. L. (2010) · Neuropsychology Review · doi:10.1007/s11065-010-9148-4 · Cited by 2,009
Evolution of the neocortex: a perspective from developmental biology
Rakic, P. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2719 · Cited by 1,565
Distinct Genetic Influences on Cortical Surface Area and Cortical Thickness
Panizzon, M. S., Fennema-Notestine, C., Eyler, L. T., Jernigan, T. L., Prom-Wormley, E., Neale, M., Jacobson, K., Lyons, M. J., Grant, M. D., Franz, C. E., et al. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp026 · Cited by 1,304
Molecular logic of neocortical projection neuron specification, development and diversity
Greig, L. C., Woodworth, M. B., Galazo, M. J., Padmanabhan, H., & Macklis, J. D. (2013) · Nature Reviews Neuroscience · doi:10.1038/nrn3586 · Cited by 863
Patterning and plasticity of the cerebral cortex
Sur, M., & Rubenstein, J. L. R. (2005) · Science · doi:10.1126/science.1112070 · Cited by 677
Metadata
- Authors
- Bishop, K. M., Goudreau, G., & O'Leary, D. D. M.
- Venue
- Science
- Published
- 2000-04-14
- Volume
- 288
- Issue
- 5464
- Pages
- 344-349
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1967679856
- Cited by
- 575
- References
- 2
- FWCI
- 8.21
- Type
- journal article
- Language
- en
- Open access
- closed
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- Bishop, K. M., Goudreau, G., & O'Leary, D. D. M. (2000). Regulation of Area Identity in the Mammalian Neocortex by Emx2 and Pax6. Science. https://doi.org/10.1126/science.288.5464.344
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
