Cited by 466Telomeres, Telomerase, and SenescenceAnimal Genetics and ReproductionPluripotent Stem Cells Research

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Extension of Cell Life-Span and Telomere Length in Animals Cloned from Senescent Somatic Cells

Lanza, Robert P., Cibelli, Jose B., Blackwell, Catherine, Cristofalo, Vincent J., Francis, Mary Kay, Baerlocher, Gabriela M., Mak, Jennifer, Schertzer, Michael, Chavez, Elizabeth A., Sawyer, Nancy, Lansdorp, Peter M., West, Michael D.·2000·Science

DOI 10.1126/science.288.5466.665

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Abstract

The potential of cloning depends in part on whether the procedure can reverse cellular aging and restore somatic cells to a phenotypically youthful state. Here, we report the birth of six healthy cloned calves derived from populations of senescent donor somatic cells. Nuclear transfer extended the replicative life-span of senescent cells (zero to four population doublings remaining) to greater than 90 population doublings. Early population doubling level complementary DNA-1 (EPC-1, an age-dependent gene) expression in cells from the cloned animals was 3.5- to 5-fold higher than that in cells from age-matched (5 to 10 months old) controls. Southern blot and flow cytometric analyses indicated that the telomeres were also extended beyond those of newborn (<2 weeks old) and age-matched control animals. The ability to regenerate animals and cells may have important implications for medicine and the study of mammalian aging.

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Authors: Lanza, R. P., Cibelli, J. B., Blackwell, C., Cristofalo, V. J., Francis, M. K., Baerlocher, G. M., Mak, J., Schertzer, M., Chavez, E. A., Sawyer, N., Lansdorp, P. M., & West, M. D.
Affiliations: Advanced Cell Technology (United States) (US)
Thomas Jefferson University (US)
Terry Fox Research Institute (CA)
University of British Columbia (CA)
Corresponding author: Lanza, Robert P.
ORCID: Lanza, Robert P.
Cibelli, Jose B.
Blackwell, Catherine
Baerlocher, Gabriela M.
Chavez, Elizabeth A.
Lansdorp, Peter M.
West, Michael D.
Venue: Science
Publisher: American Association for the Advancement of Science (AAAS)
Published: 2000-04-28
Volume: 288
Issue: 5466
Pages: 665-669
ISSN: 0036-8075 (ISSN-L)
1095-9203
DOI: 10.1126/science.288.5466.665
OpenAlex: W2141926462
Cited by: 466
References: 44
Citations by year: 2025: 4 · 2024: 2 · 2023: 10 · 2022: 8 · 2021: 10 · 2020: 4 · 2019: 9 · 2018: 3 · 2017: 7 · 2016: 7 · 2015: 7 · 2014: 13 · 2013: 16 · 2012: 16
FWCI: 34.86
Type: journal article
Language: en
Open access: closed
Locations: Science (publishedVersion)
PubMed (publishedVersion)
ScholarWorks@UMassAmherst (University of Massachusetts Amherst) (submittedVersion)
Funders: National Institutes of Health (1r01gm056162-01)
National Institute on Aging (AG00378)
National Institute of General Medical Sciences (GM56162)
National Institute of Allergy and Infectious Diseases (AI 29524)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Telomeres, Telomerase, and Senescence
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Animal Genetics and Reproduction
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords: somatic cell nuclear transfer, cloning, cellular aging, replicative lifespan, telomere length, telomere elongation, cloned calves, age-related gene expression, regenerative medicine, mammalian aging
MeSH terms: Pigment Epithelium-Derived Factor, Animals, Cattle, Cell Division, Cells, Cultured, Clone Cells, Embryo Transfer, Eye Proteins, Female, Fibroblasts, Flow Cytometry, Longevity, Nerve Growth Factors, Proteins, RNA, Messenger, Blotting, Southern, Serpins, Matched-Pair Analysis, Telomere, Cellular Senescence, In Situ Hybridization, Fluorescence, DNA, Complementary, Cloning, Organism, Nuclear Transfer Techniques

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Extension of Cell Life-Span and Telomere Length in Animals Cloned from Senescent Somatic Cells

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