Telomere Length Maintenance, Shortening, and Lengthening
Abstract
Telomeres maintain chromosome stability and cell replicative capacity. Telomere shortening occurs concomitant with aging. Short telomeres are associated with some diseases, such as dyskeratosis congenita, idiopathic pulmonary fibrosis, and aplastic anemia. Telomeres are longer in pluripotent stem cells than in somatic cells and lengthen significantly during preimplantation development. Furthermore, telomere elongation during somatic cell reprogramming is of great importance in the acquisition of authentic pluripotency. This review focuses primarily on regulatory mechanisms of telomere length maintenance in pluripotent cells, telomere length extension in early embryo development, and also telomere rejuvenation in somatic cell reprogramming. Telomere related diseases are also discussed in this review. J. Cell. Physiol. 229: 1323–1329, 2014. © 2014 Wiley Periodicals, Inc.
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Homeostasis of the telomeric ends can be regulated by protein parts of the shelterin complex.
“It has been shown that homeostasis of the telomeric ends can be regulated by protein parts of the shelterin complex [186,187].”
From Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy (2024) · cites this paper as [186]
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Current and Future Trends of Colorectal Cancer Treatment: Exploring Advances in Immunotherapy
Nikolouzakis, T. K., Chrysos, E., Docea, A. O., Fragkiadaki, P., Souglakos, J., Tsiaoussis, J., & Tsatsakis, A. (2024) · Cancers · doi:10.3390/cancers16111995 · Cited by 37 · see citing works
Luu, H. N., Qi, M., Wang, R., Adams-Haduch, J., Miljkovic, I., Opresko, P. L., Jin, A., Koh, W.-P., & Yuan, J.-M. (2019) · Clinical and Translational Gastroenterology · doi:10.14309/ctg.0000000000000043 · Cited by 20 · see citing works
Telomeres and telomerase in the clinical management of colorectal cancer
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- Authors
- Zhao, Z., Pan, X., Liu, L., & Liu, N.
- Affiliations
- Nankai University (CN)
- Yale University (US)
- Corresponding author
- Liu, Lin
- Liu, Na
- Venue
- Journal of Cellular Physiology
- Publisher
- Wiley
- Published
- 2014-06-27
- Volume
- 229
- Issue
- 10
- Pages
- 1323-1329
- ISSN
- 0021-9541 (ISSN-L)
- 1097-4652
- OpenAlex
- W1869104478
- Cited by
- 66
- References
- 18
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 8 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 8 · 2018: 9 · 2017: 5 · 2016: 4 · 2015: 3 · 2014: 5
- FWCI
- 0.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Cellular Physiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31000651)
- China MOST National Major Basic Research Program (973 Program) (2012CB911202)
- China Scholarship Council (201208120050)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- telomere maintenance, telomere shortening, telomere elongation, pluripotent stem cells, somatic cell reprogramming, preimplantation embryo development, dyskeratosis congenita, idiopathic pulmonary fibrosis, aplastic anemia, aging, chromosome stability
- MeSH terms
- Animals, Cell Differentiation, Humans, Telomere, Cellular Senescence, Gene Expression Regulation, Developmental, Cell Lineage, Pluripotent Stem Cells, Embryonic Stem Cells, Telomere Homeostasis, Telomere Shortening, Cellular Reprogramming
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