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Cooperative Regulation of Cell Polarity and Growth by Drosophila Tumor Suppressors
Abstract
Loss of cell polarity and tissue architecture are characteristics of malignant cancers derived from epithelial tissues. We provide evidence from Drosophila that a group of membrane-associated proteins act in concert to regulate both epithelial structure and cell proliferation. Scribble (Scrib) is a cell junction–localized protein required for polarization of embryonic and, as demonstrated here, imaginal disc and follicular epithelia. We show that the tumor suppressors lethal giant larvae ( lgl ) and discs-large ( dlg ) have identical effects on all three epithelia, and that scrib also acts as a tumor suppressor. Scrib and Dlg colocalize and overlap with Lgl in epithelia; activity of all three genes is required for cortical localization of Lgl and junctional localization of Scrib and Dlg. scrib , dlg , and lgl show strong genetic interactions. Our data indicate that the three tumor suppressors act together in a common pathway to regulate cell polarity and growth control.
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Localization of apical epithelial determinants by the basolateral PDZ protein Scribble
Bilder, D., & Perrimon, N. (2000) · Nature · doi:10.1038/35001108 · Cited by 716
Self-citation
Research works printed but not linked: 26
- Harrison D. A., Perrimon N., Curr. Biol. 3, 424 (1993); · DOI
- Jacob L., Opper M., Metzroth B., Phannavong B., Mechler B. M., Cell 50, 215 (1987). · DOI
- 10.1083/jcb.127.5.1345 · DOI
- Goode S., Perrimon N., Genes Dev. 11, 2532 (1997). · DOI
- 10.1016/0092-8674(81)90009-X · DOI · Paper page
- 10.1093/genetics/144.4.1673 · DOI · Paper page
- Tepass U., Theres C., Knust E., Cell 61, 787 (1990). · DOI · Paper page
- Perrimon N., Dev. Biol. 127, 392 (1988). · DOI
- Woods D. F., Bryant P. J., Dev. Biol. 134, 222 (1989). · DOI · Paper page
- Manfruelli P., Arquier N., Hanratty W. P., Semeriva M., Development 122, 2283 (1996). · DOI
- Bryant P. J., Dev. Genet. 20, 75 (1997). · doi:10.1002/(sici)1520-6408(1997)20:2<75::aid-dvg1>3.0.co;2-5
- 10.1242/jcs.1994.Supplement_18.4 · DOI
- 10.1083/jcb.134.6.1469 · DOI · Paper page
- Gateff E., Schneiderman H. A., Natl. Cancer Inst. Monogr. 31, 365 (1969).
- Tepass U., Bioessays 19, 673 (1997). · DOI
- 10.1016/S0896-6273(00)80472-9 · DOI · Paper page
- 10.1083/jcb.146.1.125 · DOI
- 10.1002/j.1460-2075.1996.tb01039.x · DOI · Paper page
- 10.1016/S0092-8674(00)81435-X · DOI · Paper page
- 10.1126/science.287.5458.1606 · DOI · Paper page
- Koyama K., et al., Cytogenet. Cell Genet. 72, 78 (1996). · doi:10.1159/000134167
- Strand D., et al., Oncogene 11, 291 (1995).
- Dimitratos S. D., Woods D. F., Stathakis D. G., Bryant P. J., Bioessays 21, 912 (1999). · DOI · Paper page
- 10.1126/science.272.5264.1020 · DOI · Paper page
- Mukherjee A., Lakhotia S. C., Roy J. K., Mech. Dev. 51, 227 (1995). · DOI
- I. Davis C. H. Girdham P. H. O'Farrell Dev. Biol. 170 726 (1995). · doi:10.1006/dbio.1995.1251
Cited by
Bissell, M. J., & Radisky, D. (2001) · Nature Reviews Cancer · doi:10.1038/35094059 · Cited by 2,180
Cox, T. R., & Erler, J. T. (2011) · Disease Models & Mechanisms · doi:10.1242/dmm.004077 · Cited by 1,569
Regulation of Cerebral Cortical Size by Control of Cell Cycle Exit in Neural Precursors
Chenn, A., & Walsh, C. A. (2002) · Science · doi:10.1126/science.1074192 · Cited by 1,431
Adaptation of core mechanisms to generate cell polarity
Nelson, W. J. (2003) · Nature · doi:10.1038/nature01602 · Cited by 716
scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila
Brumby, A. M., & Richardson, H. E. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg548 · Cited by 628
Metadata
- Authors
- Bilder, D., Li, M., & Perrimon, N.
- Venue
- Science
- Published
- 2000-07-07
- Volume
- 289
- Issue
- 5476
- Pages
- 113-116
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W1976577398
- Cited by
- 919
- References
- 2
- FWCI
- 18.71
- Type
- journal article
- Language
- en
- Open access
- closed
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