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Pol κ: A DNA Polymerase Required for Sister Chromatid Cohesion
Abstract
Establishment of cohesion between sister chromatids is coupled to replication fork passage through an unknown mechanism. Here we report that TRF4 , an evolutionarily conserved gene necessary for chromosome segregation, encodes a DNA polymerase with β-polymerase–like properties. A double mutant in the redundant homologs, TRF4 and TRF5 , is unable to complete S phase, whereas a trf4 single mutant completes a presumably defective S phase that results in a failure of cohesion between the replicated sister chromatids. This suggests that TRF s are a key link in the coordination between DNA replication and sister chromatid cohesion. Trf4 and Trf5 represent the fourth class of essential nuclear DNA polymerases (designated DNA polymerase kappa) in Saccharomyces cerevisiae and probably in all eukaryotes.
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Cited by
Nasmyth, K. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.091334 · Cited by 805
Error-Prone Repair DNA Polymerases in Prokaryotes and Eukaryotes
Goodman, M. F. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.083101.124707 · Cited by 727
Hübscher, U., Maga, G., & Spadari, S. (2002) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.71.090501.150041 · Cited by 691
A New Yeast Poly(A) Polymerase Complex Involved in RNA Quality Control
Vaňáčová, Š., Wolf, J., Martin, G., Blank, D., Dettwiler, S., Friedlein, A., Langen, H., Keith, G., & Keller, W. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030189 · Cited by 567
Bebenek, K., & Kunkel, T. A. (2004) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(04)69005-x · Cited by 258
Metadata
- Authors
- Wang, Z., Castaño, I. B., De Las Peñas, A., Adams, C., & Christman, M. F.
- Venue
- Science
- Published
- 2000-08-04
- Volume
- 289
- Issue
- 5480
- Pages
- 774-779
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2026061099
- Cited by
- 186
- References
- 0
- FWCI
- 9.46
- Type
- journal article
- Language
- en
- Open access
- closed
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- Wang, Z., Castaño, I. B., De Las Peñas, A., Adams, C., & Christman, M. F. (2000). Pol κ: A DNA Polymerase Required for Sister Chromatid Cohesion. Science. https://doi.org/10.1126/science.289.5480.774
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
