The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Respiration and Parturition Affected by Conditional Overexpression of the Ca 2+ -Activated K + Channel Subunit, SK3
Abstract
In excitable cells, small-conductance Ca 2+ -activated potassium channels (SK channels) are responsible for the slow after-hyperpolarization that often follows an action potential. Three SK channel subunits have been molecularly characterized. The SK3 gene was targeted by homologous recombination for the insertion of a gene switch that permitted experimental regulation of SK3 expression while retaining normal SK3 promoter function. An absence of SK3 did not present overt phenotypic consequences. However, SK3 overexpression induced abnormal respiratory responses to hypoxia and compromised parturition. Both conditions were corrected by silencing the gene. The results implicate SK3 channels as potential therapeutic targets for disorders such as sleep apnea or sudden infant death syndrome and for regulating uterine contractions during labor.
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Cites
A Potassium Channel Mutation in Neonatal Human Epilepsy
Biervert, C., Schroeder, B. C., Kubisch, C., Berkovic, S. F., Propping, P., Jentsch, T. J., & Steinlein, O. K. (1998) · Science · doi:10.1126/science.279.5349.403 · Cited by 1,073
Cited by
Ca2+-activated K+ channels: molecular determinants and function of the SK family
Stocker, M. (2004) · Nature Reviews Neuroscience · doi:10.1038/nrn1516 · Cited by 531
Liao, J. J.-L. (2007) · Journal of Medicinal Chemistry · doi:10.1021/jm0608107 · Cited by 507
Hammond, R. S., Bond, C. T., Strassmaier, T., Jennifer Ngo-Anh, T., Adelman, J. P., Maylie, J., & Stackman, R. W. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.4106-05.2006 · Cited by 215
Self-citationPedarzani, P., & Stocker, M. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8216-x · Cited by 173
An inducible and reversible mouse genetic rescue system
Zeng, H., Horie, K., Madisen, L., Pavlova, M. N., Gragerova, G., Rohde, A. D., Schimpf, B. A., Liang, Y., Ojala, E., Kramer, F., et al. (2008) · PLoS Genetics · doi:10.1371/journal.pgen.1000069 · Cited by 87
“Attempts to target both tTA and TRE together into an endogenous gene locus to achieve inducible activation and inactivation were successful in a few cases [24,25,26], but this method is not applicable to most other genes as the TRE is easily subject to activation from nearby enhancers independent from tTA.”
Method
Metadata
- Authors
- Bond, C. T., Sprengel, R., Bissonnette, J. M., Kaufmann, W. A., Pribnow, D., Neelands, T., Storck, T., Baetscher, M., Jerecic, J., Maylie, J., Knaus, H.-G., Seeburg, P. H., & Adelman, J. P.
- Venue
- Science
- Published
- 2000-09-15
- Volume
- 289
- Issue
- 5486
- Pages
- 1942-1946
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2156578605
- Cited by
- 184
- References
- 1
- FWCI
- 3.83
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Respiration and Parturition Affected by Conditional Overexpression of the Ca 2+ -Activated K + Channel Subunit, SK3. https://app.cochat.ai/papers/10.1126/science.289.5486.1942
- The paper
- Bond, C. T., Sprengel, R., Bissonnette, J. M., Kaufmann, W. A., Pribnow, D., Neelands, T., Storck, T., Baetscher, M., Jerecic, J., Maylie, J., Knaus, H.-G., Seeburg, P. H., & Adelman, J. P. (2000). Respiration and Parturition Affected by Conditional Overexpression of the Ca 2+ -Activated K + Channel Subunit, SK3. Science. https://doi.org/10.1126/science.289.5486.1942
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
