Small-Conductance Ca2+-Activated K+Channel Type 2 (SK2) Modulates Hippocampal Learning, Memory, and Synaptic Plasticity

Place navigation impaired in rats with hippocampal lesions

Morris, R. G. M., Garrud, P., Rawlins, J. N. P., & O'Keefe, J. (1982) · Nature · doi:10.1038/297681a0 · Cited by 6,340 · see citing works

Memory and the hippocampus: A synthesis from findings with rats, monkeys, and humans.

Squire, L. R. (1992) · Psychological Review · doi:10.1037/0033-295x.99.2.195 · Cited by 5,376 · see citing works

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037/0735-7044.106.2.274 · Cited by 3,292 · see citing works

Differential contribution of amygdala and hippocampus to cued and contextual fear conditioning.

Phillips, R. G., & LeDoux, J. E. (1992) · Behavioral Neuroscience · doi:10.1037//0735-7044.106.2.274 · Cited by 3,262 · see citing works

Long-Term Potentiation--A Decade of Progress?

Malenka, R. C., & Nicoll, A. R. A. (1999) · Science · doi:10.1126/science.285.5435.1870 · Cited by 2,729 · see citing works

Modality-Specific Retrograde Amnesia of Fear

Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483 · see citing works

A cortical–hippocampal system for declarative memory

Eichenbaum, H. (2000) · Nature reviews. Neuroscience · doi:10.1038/35036213 · Cited by 1,725 · see citing works

Short-Term Synaptic Plasticity

Zucker, R. S. (1989) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.12.030189.000305 · Cited by 1,450 · see citing works

Fear conditioning induces associative long-term potentiation in the amygdala

Rogan, M. T., Stäubli, U. V., & LeDoux, J. E. (1997) · Nature · doi:10.1038/37601 · Cited by 1,310 · see citing works

Small-Conductance, Calcium-Activated Potassium Channels from Mammalian Brain

Kohler, M.-L., Hirschberg, B., Bond, C. T., Kinzie, J. M., Marrion, N. V., Maylie, J., & Adelman, J. P. (1996) · Science · doi:10.1126/science.273.5282.1709 · Cited by 946 · see citing works

Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze.

Gallagher, M., Burwell, R. D., & Burchinal, M. A. (2015) · Behavioral Neuroscience · doi:10.1037/bne0000080 · Cited by 861 · see citing works

Emotional memory systems in the brain

LeDoux, J. E. (1993) · Behavioural Brain Research · doi:10.1016/0166-4328(93)90091-4 · Cited by 812 · see citing works

Parallel information processing in the water maze: Evidence for independent memory systems involving dorsal striatum and hippocampus

McDonald, R. J., & White, N. M. (1994) · Behavioral and Neural Biology · doi:10.1016/s0163-1047(05)80009-3 · Cited by 722 · see citing works

Severity of spatial learning impairment in aging: Development of a learning index for performance in the Morris water maze.

Gallagher, M., Burwell, R. D., & Burchinal, M. (1993) · Behavioral Neuroscience · doi:10.1037/0735-7044.107.4.618 · Cited by 675 · see citing works

Reversible neural inactivation reveals hippocampal participation in several memory processes

Riedel, G., Micheau, J., Lam, A. G. M., Roloff, E. V. L., Martin, S. J., Bridge, H., de Hoz, L., Poeschel, B., McCulloch, J., & Morris, R. (1999) · Nature Neuroscience · doi:10.1038/13202 · Cited by 478 · see citing works

SK channels and NMDA receptors form a Ca2+-mediated feedback loop in dendritic spines

Ngo‐Anh, T. J., Bloodgood, B. L., Lin, M., Sabatini, B. L., Maylie, J., & Adelman, J. P. (2005) · Nature Neuroscience · doi:10.1038/nn1449 · Cited by 442 · see citing works

An apamin-sensitive Ca 2+ -activated K + current in hippocampal pyramidal neurons

Stocker, M., Krause, M., & Pedarzani, P. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.8.4662 · Cited by 389 · see citing works

Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task

Logue, S. F., Paylor, R., & Wehner, J. M. (1997) · Behavioral Neuroscience · doi:10.1037/0735-7044.111.1.104 · Cited by 385 · see citing works

Hippocampal lesions cause learning deficits in inbred mice in the Morris water maze and conditioned-fear task.

Logue, S. F., Paylor, R. E., & Wehner, J. M. (1997) · Behavioral Neuroscience · doi:10.1037//0735-7044.111.1.104 · Cited by 379 · see citing works

Differential Distribution of Three Ca2+-Activated K+ Channel Subunits, SK1, SK2, and SK3, in the Adult Rat Central Nervous System

Stocker, M., & Pedarzani, P. (2000) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2000.0842 · Cited by 374 · see citing works

The hippocampus and mechanisms of declarative memory

Eichenbaum, H. (1999) · Behavioural Brain Research · doi:10.1016/s0166-4328(99)00044-3 · Cited by 353 · see citing works

LTP is accompanied by commensurate enhancement of auditory-evoked responses in a fear conditioning circuit

Rogan, M. T., & LeDoux, J. E. (1995) · Neuron · doi:10.1016/0896-6273(95)90070-5 · Cited by 292 · see citing works

Small Conductance Ca2+-Activated K+ Channel Knock-Out Mice Reveal the Identity of Calcium-Dependent Afterhyperpolarization Currents

Bond, C. T. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0182-04.2004 · Cited by 291 · see citing works

Small Conductance Ca2+-Activated K+Channels Modulate Synaptic Plasticity and Memory Encoding

Stackman, R. W., Hammond, R., Linardatos, E., Gerlach, A. C., Maylie, J., Adelman, J. P., & Tzounopoulos, T. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10163.2002 · Cited by 275 · see citing works

Unique Roles of SK and Kv4.2 Potassium Channels in Dendritic Integration

Cai, X., Liang, C. W., Muralidharan, S., Kao, J. P. Y., Tang, C., & Thompson, S. M. (2004) · Neuron · doi:10.1016/j.neuron.2004.09.026 · Cited by 266 · see citing works

SK channels regulate excitatory synaptic transmission and plasticity in the lateral amygdala

Faber, E. S. L., Delaney, A., & Sah, P. (2005) · Nature Neuroscience · doi:10.1038/nn1450 · Cited by 237 · see citing works

Regional Differences in Distribution and Functional Expression of Small-Conductance Ca2+-Activated K+Channels in Rat Brain

Sailer, C. A., Hu, H., Kaufmann, W. A., Trieb, M., Schwarzer, C., Storm, J. F., & Knaus, H. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-22-09698.2002 · Cited by 202 · see citing works

The Role of the Amygdala in Emotional Learning

Davis, M. (1994) · International review of neurobiology · doi:10.1016/s0074-7742(08)60305-0 · Cited by 187 · see citing works

Comparative immunohistochemical distribution of three small-conductance Ca2+-activated potassium channel subunits, SK1, SK2, and SK3 in mouse brain

Sailer, C. A., Kaufmann, W. A., Marksteiner, J., & Knaus, H. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.03.002 · Cited by 185 · see citing works

Respiration and Parturition Affected by Conditional Overexpression of the Ca 2+ -Activated K + Channel Subunit, SK3

Bond, C. T., Sprengel, R., Bissonnette, J. M., Kaufmann, W. A., Pribnow, D. G., Neelands, T. R., Storck, T., Baetscher, M., Jerecı̀ć, J., Maylie, J., et al. (2000) · Science · doi:10.1126/science.289.5486.1942 · Cited by 184 · see citing works

A Novel Mechanism for the Facilitation of Theta-Induced Long-Term Potentiation by Brain-Derived Neurotrophic Factor

Kramár, E. A., Lin, B., Lin, C., Arai, A., Gall, C. M., & LYNCH, G. S. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.0800-04.2004 · Cited by 177 · see citing works

Watermaze Learning Enhances Excitability of CA1 Pyramidal Neurons

Oh, M. M., Kuo, A. G., Wu, W., Sametsky, E. A., & Disterhoft, J. F. (2003) · Journal of Neurophysiology · doi:10.1152/jn.01177.2002 · Cited by 165 · see citing works

Single Spine Ca2+Signals Evoked by Coincident EPSPs and Backpropagating Action Potentials in Spiny Stellate Cells of Layer 4 in the Juvenile Rat Somatosensory Barrel Cortex

Nevian, T., & Sakmann, B. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3332-03.2004 · Cited by 147 · see citing works

Small-conductance, Ca2+-activated K+ channel SK3 generates age-related memory and LTP deficits

Blank, T., Nijholt, I. M., Kye, M. J., Radulović, J., & Spiess, J. (2003) · Nature Neuroscience · doi:10.1038/nn1101 · Cited by 118 · see citing works

AHP reductions in rabbit hippocampal neurons during conditioning correlate with acquisition of the learned response

Disterhoft, J. F., Golden, D. T., Read, H. L., Coulter, D. A., & Alkon, D. L. (1988) · Brain Research · doi:10.1016/0006-8993(88)90593-8 · Cited by 96 · see citing works

A Novel Isoform of SK2 Assembles with Other SK Subunits in Mouse Brain

Strassmaier, T., Bond, C. T., Sailer, C. A., Knaus, H. G., Maylie, J., & Adelman, J. P. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413125200 · Cited by 86 · see citing works

Aging and Learning-Specific Changes in Single-Neuron Activity in CA1 Hippocampus During Rabbit Trace Eyeblink Conditioning

McEchron, M. D., Weible, A. P., & Disterhoft, J. F. (2001) · Journal of Neurophysiology · doi:10.1152/jn.2001.86.4.1839 · Cited by 79 · see citing works

Inhibition of apamin-sensitive calcium dependent potassium channels facilitate the induction of long-term potentiation in the CA1 region of rat hippocampus in vitro

Behnisch, T., & Reymann, K. G. (1998) · Neuroscience Letters · doi:10.1016/s0304-3940(98)00612-0 · Cited by 77 · see citing works

The small conductance Ca2+‐activated K+ channel SK3 is localized in nerve terminals of excitatory synapses of cultured mouse hippocampal neurons

Obermair, G. J., Kaufmann, W. A., Knaus, H., & Flucher, B. E. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.02488.x · Cited by 74 · see citing works

Distribution of the messenger RNA for the small conductance calcium-activated potassium channel SK3 in the adult rat brain and correlation with immunoreactivity

Tacconi, S., Carletti, R., Bunnemann, B., Plumpton, C., Pich, E. M., & Terstappen, G. C. (2001) · Neuroscience · doi:10.1016/s0306-4522(00)00486-3 · Cited by 72 · see citing works

Enhancing Synaptic Plasticity and Memory: A Role for Small-Conductance Ca2+-Activated K+ Channels

Tzounopoulos, T., & Stackman, R. W. (2003) · The Neuroscientist · doi:10.1177/1073858403259282 · Cited by 34 · see citing works

Identification of common genetic risk variants for autism spectrum disorder

Autism Spectrum Disorder Working Group of the Psychiatric Genomics Consortium, Grove, J., BUPGEN, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium, 23andMe Research Team, Ripke, S., Als, T. D., Mattheisen, M., Walters, R. K., Won, H., et al. (2019) · Nature Genetics · doi:10.1038/s41588-019-0344-8 · Cited by 2,421 · see citing works

Small-Conductance Ca2+-Activated K+Channels: Form and Function

Adelman, J. P., Maylie, J., & Sah, P. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-020911-153336 · Cited by 454 · see citing works

Age matters

McCutcheon, J. E., & Marinelli, M. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06648.x · Cited by 279 · see citing works

Ca²⁺-Activated K⁺Channels: From Protein Complexes to Function

Berkefeld, H., Fakler, B., & Schulte, U. (2010) · Physiological Reviews · doi:10.1152/physrev.00049.2009 · Cited by 274 · see citing works

The role of synaptic ion channels in synaptic plasticity

Voglis, G., & Tavernarakis, N. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400830 · Cited by 252 · see citing works

SK2 channel plasticity contributes to LTP at Schaffer collateral–CA1 synapses

Lin, M. T., Luján, R., Watanabe, M., Adelman, J. P., & Maylie, J. (2008) · Nature Neuroscience · doi:10.1038/nn2041 · Cited by 236 · see citing works

K+Channel Modulators for the Treatment of Neurological Disorders and Autoimmune Diseases

Wulff, H., & Zhorov, B. S. (2008) · Chemical Reviews · doi:10.1021/cr078234p · Cited by 224 · see citing works

Naphtho[1,2-d]thiazol-2-ylamine (SKA-31), a New Activator of KCa2 and KCa3.1 Potassium Channels, Potentiates the Endothelium-Derived Hyperpolarizing Factor Response and Lowers Blood Pressure

Sankaranarayanan, A., Raman, G., Busch, C., Schultz, T., Zimin, P. I., Hoyer, J. D., Köhler, R., & Wulff, H. (2008) · Molecular Pharmacology · doi:10.1124/mol.108.051425 · Cited by 215 · see citing works

Toward a Neurocentric View of Learning

Titley, H. K., Brunel, N., & Hansel, C. (2017) · Neuron · doi:10.1016/j.neuron.2017.05.021 · Cited by 201 · see citing works

The sigma‐1 receptor modulates NMDA receptor synaptic transmission and plasticity via SK channels in rat hippocampus

Martina, M., B.‐Turcotte, M., Halman, S., & Bergeron, R. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.116178 · Cited by 187 · see citing works

Active dendrites: colorful wings of the mysterious butterflies

Johnston, D., & Narayanan, R. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.03.004 · Cited by 186 · see citing works

Facilitation of Long-Term Potentiation by Muscarinic M1 Receptors Is Mediated by Inhibition of SK Channels

Buchanan, K. A., Petrovic, M. M., Chamberlain, S. E. L., Marrion, N. V., & Mellor, J. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.11.018 · Cited by 184 · see citing works

Molecular and cellular basis of small- and intermediate-conductance, calcium-activated potassium channel function in the brain

Pedarzani, P., & Stocker, M. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-8216-x · Cited by 173 · see citing works

Calcium-Activated Chloride Channels (CaCCs) Regulate Action Potential and Synaptic Response in Hippocampal Neurons

Huang, W. C., Xiao, S., Huang, F., Harfe, B. D., Jan, Y. N., & Jan, L. Y. (2012) · Neuron · doi:10.1016/j.neuron.2012.01.033 · Cited by 172 · see citing works

Intrinsic Plasticity Complements Long-Term Potentiation in Parallel Fiber Input Gain Control in Cerebellar Purkinje Cells

Belmeguenaï, A., Hosy, E., Bengtsson, F., Pedroarena, C. M., Piochon, C., Teuling, E., He, Q., Ohtsuki, G., de Jeu, M. T. G., Elgersma, Y., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3226-10.2010 · Cited by 158 · see citing works

M1 Muscarinic Receptors Boost Synaptic Potentials and Calcium Influx in Dendritic Spines by Inhibiting Postsynaptic SK Channels

Giessel, A. J., & Sabatini, B. L. (2010) · Neuron · doi:10.1016/j.neuron.2010.09.004 · Cited by 156 · see citing works

Learning to learn – Intrinsic plasticity as a metaplasticity mechanism for memory formation

Sehgal, M., Song, C., Ehlers, V. L., & Moyer, J. R. (2013) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2013.07.008 · Cited by 150 · see citing works

Cytokine and Growth Factor Activation In Vivo and In Vitro after Spinal Cord Injury

García, E., Aguilar-Cevallos, J., Silva‐García, R., & Ibarra, A. (2016) · Mediators of Inflammation · doi:10.1155/2016/9476020 · Cited by 152 · see citing works

Selective Positive Modulator of Calcium-Activated Potassium Channels Exerts Beneficial Effects in a Mouse Model of Spinocerebellar Ataxia Type 2

Kasumu, A. W., Hougaard, C. Ø., Rode, F., Jacobsen, T. A., Sabatier, J., Eriksen, B. L., Strøbæk, D., Liang, X., Egorova, P. A., Vorontsova, D., et al. (2012) · Chemistry & Biology · doi:10.1016/j.chembiol.2012.07.013 · Cited by 148 · see citing works

Dendritic ion channel trafficking and plasticity

Shah, M. M., Hammond, R., & Hoffman, D. A. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.03.002 · Cited by 138 · see citing works

UBE3A Regulates Synaptic Plasticity and Learning and Memory by Controlling SK2 Channel Endocytosis

Sun, J., Zhu, G., Liu, Y., Standley, S., Ji, A., Tunuguntla, R., Wang, Y., Claus, C., Luo, Y., Baudry, M., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.06.023 · Cited by 131 · see citing works

FUNCTIONS OF SK CHANNELS IN CENTRAL NEURONS

Faber, E. S. L., & Sah, P. (2007) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2007.04725.x · Cited by 120 · see citing works

Early presynaptic and postsynaptic calcium signaling abnormalities mask underlying synaptic depression in presymptomatic Alzheimer’s disease mice

Chakroborty, S., Kim, J., Schneider, C., Jacobson, C., Molgo, J., & Stutzmann, G. E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0936-12.2012 · Cited by 118 · see citing works

Pharmacology of Small- and Intermediate-Conductance Calcium-Activated Potassium Channels

Brown, B. M., Shim, H., Christophersen, P., & Wulff, H. (2019) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-010919-023420 · Cited by 113 · see citing works

Modulation of SK Channel Trafficking by Beta Adrenoceptors Enhances Excitatory Synaptic Transmission and Plasticity in the Amygdala

Faber, E. S. L., Delaney, A., Power, J., Sedlak, P. L., Crane, J. W., & Sah, P. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.1796-08.2008 · Cited by 114 · see citing works

Rapamycin reverses status epilepticus-induced memory deficits and dendritic damage

Brewster, A. L., Lugo, J. N., Patil, V. V., Lee, W. L., Qian, Y., Vanegas, F., & Anderson, A. E. (2013) · PLoS ONE · doi:10.1371/journal.pone.0057808 · Cited by 112 · see citing works

Functional Roles of a Ca 2+ -Activated K + Channel in Atrioventricular Nodes

Zhang, Q., Timofeyev, V., Lü, L., Li, N., Singapuri, A., Long, M., Bond, C. T., Adelman, J. P., & Chiamvimonvat, N. (2007) · Circulation Research · doi:10.1161/circresaha.107.161778 · Cited by 112 · see citing works

SK2 Channel Modulation Contributes to Compartment-Specific Dendritic Plasticity in Cerebellar Purkinje Cells

Ohtsuki, G., Piochon, C., Adelman, J. P., & Hansel, C. (2012) · Neuron · doi:10.1016/j.neuron.2012.05.025 · Cited by 110 · see citing works

New sites of action for GIRK and SK channels

Luján, R., Maylie, J., & Adelman, J. P. (2009) · Nature reviews. Neuroscience · doi:10.1038/nrn2668 · Cited by 107 · see citing works

Chronic Intermittent Ethanol Exposure Enhances the Excitability and Synaptic Plasticity of Lateral Orbitofrontal Cortex Neurons and Induces a Tolerance to the Acute Inhibitory Actions of Ethanol

Nimitvilai, S., Lopez, M. F., Mulholland, P. J., & Woodward, J. J. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.250 · Cited by 99 · see citing works

International Union of Basic and Clinical Pharmacology. C. Nomenclature and Properties of Calcium-Activated and Sodium-Activated Potassium Channels

Kaczmarek, L. K., Aldrich, R. W., Chandy, K. G., Grissmer, S., Wei, A. D., & Wulff, H. (2016) · Pharmacological Reviews · doi:10.1124/pr.116.012864 · Cited by 105 · see citing works

Regulation of Surface Localization of the Small Conductance Ca2+-activated Potassium Channel, Sk2, through Direct Phosphorylation by cAMP-dependent Protein Kinase

Ren, Y., Barnwell, L. F., Alexander, J. C., Lubin, F. D., Adelman, J. P., Pfaffinger, P. J., Schrader, L. A., & Anderson, A. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m513125200 · Cited by 103 · see citing works

Endothelial Small-Conductance and Intermediate-Conductance KCa Channels

Wulff, H., & Köhler, R. (2012) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0b013e318279ba20 · Cited by 94 · see citing works

Emerging pathways driving early synaptic pathology in Alzheimer's disease

Briggs, C. A., Chakroborty, S., & Stutzmann, G. E. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.088 · Cited by 91 · see citing works

Potassium Channels: Newly Found Players in Synaptic Plasticity

Kim, J., & Hoffman, D. A. (2007) · The Neuroscientist · doi:10.1177/1073858408315041 · Cited by 89 · see citing works

Functions and Modulation of Neuronal SK Channels

Faber, E. S. L. (2009) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-009-9062-7 · Cited by 91 · see citing works

Sustaining Sleep Spindles through Enhanced SK2-Channel Activity Consolidates Sleep and Elevates Arousal Threshold

Wimmer, R. D., Astori, S., Bond, C. T., Rovó, Z., Chatton, J.-Y., Adelman, J. P., Franken, P., & Lüthi, A. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2313-12.2012 · Cited by 90 · see citing works

Common risk variants identified in autism spectrum disorder

Grove, J., Ripke, S., Als, T. D., Mattheisen, M., Walters, R., Won, H., Pallesen, J., Agerbo, E., Andreassen, O. A., Anney, R., et al. (2017) · doi:10.1101/224774 · Cited by 89 · see citing works

Critical roles of a small conductance Ca2+-activated K+ channel (SK3) in the repolarization process of atrial myocytes

Zhang, X.-D., Timofeyev, V., Li, N., Myers, R. E., Zhang, D., Singapuri, A., Lau, V. C., Bond, C. T., Adelman, J. P., Lieu, D. K., et al. (2013) · Cardiovascular Research · doi:10.1093/cvr/cvt262 · Cited by 86 · see citing works

Small conductance calcium-activated potassium channels: From structure to function

Weatherall, K. L., Goodchild, S. J., Jane, D. E., & Marrion, N. V. (2010) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2010.03.002 · Cited by 84 · see citing works

Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity

Johnson, S. L., Kuhn, S. A. C., Franz, C., Ingham, N. J., Furness, D. N., Knipper, M., Steel, K. P., Adelman, J. P., Holley, M. C., & Marcotti, W. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219578110 · Cited by 80 · see citing works

Signaling in dendritic spines and spine microdomains

Chen, Y., & Sabatini, B. L. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.03.003 · Cited by 80 · see citing works

SK2 Channels Are Neuroprotective for Ischemia-Induced Neuronal Cell Death

Allen, D., Nakayama, S., Kuroiwa, M., Nakano, T., Palmateer, J., Kosaka, Y., Ballesteros, C., Watanabe, M., Bond, C. T., Luján, R., et al. (2011) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2011.90 · Cited by 75 · see citing works

Inhibition of the Ca2+-Dependent K+Channel,KCNN4/KCa3.1, Improves Tissue Protection and Locomotor Recovery after Spinal Cord Injury

Bouhy, D., Ghasemlou, N., Lively, S. S., Redensek, A., Rathore, K. I., Schlichter, L. C., & David, S. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0047-11.2011 · Cited by 75 · see citing works

Selective phosphorylation modulates the PIP2 sensitivity of the CaM–SK channel complex

Zhang, M., Meng, X.-Y., Cui, M., Pascal, J. M., Logothetis, D. E., & Zhang, J.-F. (2014) · Nature Chemical Biology · doi:10.1038/nchembio.1592 · Cited by 74 · see citing works

Neurotransmitter Modulation of Small-Conductance Ca2+-Activated K+ Channels by Regulation of Ca2+ Gating

Maingret, F., Coste, B., Hao, J., Giamarchi, A., Allen, D., Crest, M., Litchfield, D. W., Adelman, J. P., & Delmas, P. (2008) · Neuron · doi:10.1016/j.neuron.2008.05.026 · Cited by 72 · see citing works

A CAG repeat polymorphism of KCNN3 predicts SK3 channel function and cognitive performance in schizophrenia

Grube, S., Gerchen, M. F., Adamcio, B., Pardo, L. A., Martin, S., Malzahn, D., Papiol, S., Begemann, M., Ribbe, K., Friedrichs, H., et al. (2011) · EMBO Molecular Medicine · doi:10.1002/emmm.201100135 · Cited by 71 · see citing works

Small Conductance Calcium-Activated Potassium Type 2 Channels Regulate Alcohol-Associated Plasticity of Glutamatergic Synapses

Mulholland, P. J., Becker, H. C., Woodward, J. J., & Chandler, L. J. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.09.025 · Cited by 68 · see citing works

Optogenetic photochemical control of designer K+channels in mammalian neurons

Fortin, D. L., Dunn, T., Fedorchak, A. V., Allen, D., Montpetit, R., Banghart, M. R., Trauner, D. H., Adelman, J. P., & Krämer, R. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00251.2011 · Cited by 68 · see citing works

Intrinsic Excitability Increase in Cerebellar Purkinje Cells after Delay Eye-Blink Conditioning in Mice

Titley, H. K., Watkins, G. V., Lin, C., Weiss, C., McCarthy, M., Disterhoft, J. F., & Hansel, C. (2020) · Journal of Neuroscience · doi:10.1523/jneurosci.2259-19.2019 · Cited by 67 · see citing works

SK (KCa2) Channels Do Not Control Somatic Excitability in CA1 Pyramidal Neurons But Can Be Activated by Dendritic Excitatory Synapses and Regulate Their Impact

Gu, N., Hu, H., Vervaeke, K., & Storm, J. F. (2008) · Journal of Neurophysiology · doi:10.1152/jn.90433.2008 · Cited by 65 · see citing works

An Amino Acid Outside the Pore Region Influences Apamin Sensitivity in Small Conductance Ca2+-activated K+ Channels

Nolting, A., Ferraro, T., D’hoedt, D., & Stocker, M. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m607213200 · Cited by 66 · see citing works

Tuning the excitability of midbrain dopamine neurons by modulating the Ca2+ sensitivity of SK channels

Ji, H., Hougaard, C. Ø., Herrik, K. F., Strøbæk, D., Christophersen, P., & Shepard, P. D. (2009) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2009.06735.x · Cited by 64 · see citing works

SK channel blockade reverses cognitive and motor deficits induced by nigrostriatal dopamine lesions in rats

Chen, L., Deltheil, T., Turle-Lorenzo, N., Liberge, M., Rosier, C., Watabe, I., Sréng, L., Amalric, M., & Mourre, C. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000236 · Cited by 64 · see citing works

Blockade of IP3-mediated SK channel signaling in the rat medial prefrontal cortex improves spatial working memoryPreprint

Brennan, A. R., Dolinsky, B., Vu, M.-A. T., Stanley, M., Yeckel, M. F., & Arnsten, A. F. T. (2008) · Learning & Memory · doi:10.1101/lm.767408 · Cited by 63 · see citing works

Complementary functions of SK and Kv7/M potassium channels in excitability control and synaptic integration in rat hippocampal dentate granule cells

Mateos‐Aparicio, P., Murphy, R., & Storm, J. F. (2013) · The Journal of Physiology · doi:10.1113/jphysiol.2013.267872 · Cited by 61 · see citing works

In vivo characterisation of the small-conductance KCa (SK) channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) as a potential anticonvulsant

Anderson, N. J., Slough, S., & Watson, W. P. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.07.007 · Cited by 61 · see citing works

Sizing up Ethanol‐Induced Plasticity: The Role of Small and Large Conductance Calcium‐Activated Potassium Channels

Mulholland, P. J., Hopf, F. W., Bukiya, A. N., Martin, G. E., Liu, J., Dopico, A. M., Bonci, A., Treistman, S. N., & Chandler, L. J. (2009) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2009.00936.x · Cited by 61 · see citing works

The SK2-long isoform directs synaptic localization and function of SK2-containing channels

Allen, D., Bond, C. T., Luján, R., Ballesteros‐Merino, C., Lin, M. T., Wang, K., Klett, N. J., Watanabe, M., Shigemoto, R., Stackman, R. W., et al. (2011) · Nature Neuroscience · doi:10.1038/nn.2832 · Cited by 59 · see citing works

Bee Venom for the Treatment of Parkinson Disease – A Randomized Controlled Clinical Trial

Hartmann, A., Muellner, J., Meier, N., Hesekamp, H., van Meerbeeck, P., Habert, M., Kas, A., Tanguy, M., Mazmanian, M., Hervé, O., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0158235 · Cited by 59 · see citing works

Amnestic Concentrations of Sevoflurane Inhibit Synaptic Plasticity of Hippocampal CA1 Neurons through γ-Aminobutyric Acid–mediated Mechanisms

Ishizeki, J., Nishikawa, K., Kubo, K., Saito, S., & Goto, F. (2008) · Anesthesiology · doi:10.1097/aln.0b013e318164cfba · Cited by 58 · see citing works

Calcium Microdomains Near R-Type Calcium Channels Control the Induction of Presynaptic Long-Term Potentiation at Parallel Fiber to Purkinje Cell Synapses

Myoga, M. H., & Regehr, W. G. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5252-10.2011 · Cited by 56 · see citing works

Genetic KCa3.1-Deficiency Produces Locomotor Hyperactivity and Alterations in Cerebral Monoamine Levels

Lambertsen, K. L., Gramsbergen, J. B., Sivasaravanaparan, M., Ditzel, N., Møller, L. S., Oliván‐Viguera, A., Rabjerg, M., Wulff, H., & Köhler, R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047744 · Cited by 54 · see citing works

KCNN Genes that Encode Small-Conductance Ca2+-Activated K+ Channels Influence Alcohol and Drug Addiction

Padula, A. E., Griffin, W. C., Lopez, M. F., Nimitvilai, S., Cannady, R., McGuier, N. S., Chesler, E. J., Miles, M. F., Williams, R. W., Randall, P. K., et al. (2015) · Neuropsychopharmacology · doi:10.1038/npp.2015.42 · Cited by 54 · see citing works

In vivo pharmacological manipulation of small conductance Ca2+-activated K+ channels influences motor behavior, object memory and fear conditioning

Vick, K. A., Guidi, M., & Stackman, R. W. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.11.008 · Cited by 53 · see citing works

The therapeutic potential of small-conductance KCa2 channels in neurodegenerative and psychiatric diseases

Lam, J., Coleman, N., Garing, A. L. A., & Wulff, H. (2013) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2013.823161 · Cited by 52 · see citing works

Variants in the SK2 channel gene (KCNN2) lead to dominant neurodevelopmental movement disorders

Mochel, F., Rastetter, A., Ceulemans, B., Platzer, K., Yang, S., Shinde, D. N., Helbig, K. L., Lopergolo, D., Mari, F., Renieri, A., et al. (2020) · Brain · doi:10.1093/brain/awaa346 · Cited by 52 · see citing works

Negative Gating Modulation by (R)-N-(Benzimidazol-2-yl)-1,2,3,4-tetrahydro-1-naphthylamine (NS8593) Depends on Residues in the Inner Pore Vestibule: Pharmacological Evidence of Deep-Pore Gating of KCa2 Channels

Jenkins, D. P., Strøbæk, D., Hougaard, C. Ø., Jensen, M. L., Hummel, R., Sørensen, U. S., Christophersen, P., & Wulff, H. (2011) · Molecular Pharmacology · doi:10.1124/mol.110.069807 · Cited by 51 · see citing works

Dyshomeostatic modulation of Ca2+-activated K+ channels in a human neuronal model of KCNQ2 encephalopathy

Simkin, D., Marshall, K. A., Vanoye, C. G., Desai, R. R., Bustos, B. I., Piyevsky, B. N., Ortega, J. A., Forrest, M. P., Robertson, G. L., Penzes, P., et al. (2021) · eLife · doi:10.7554/elife.64434 · Cited by 51 · see citing works

Small-conductance, Ca2+-activated K+ channel 2 is the key functional component of SK channels in mouse urinary bladder

Thorneloe, K. S., Knorn, A. M., Doetsch, P. E., Lashinger, E. S. R., Liu, A. X., Bond, C. T., Adelman, J. P., & Nelson, M. T. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00840.2006 · Cited by 51 · see citing works

Intellectual Disability and Potassium Channelopathies: A Systematic Review

Kessi, M., Chen, B., Peng, J., Tang, Y., Olatoutou, E., He, F. P., Yang, L., & Yin, F. (2020) · Frontiers in Genetics · doi:10.3389/fgene.2020.00614 · Cited by 48 · see citing works

Enhanced dendritic spine number of neurons of the prefrontal cortex, hippocampus, and nucleus accumbens in old rats after chronic donepezil administration

Alcántara-González, F., Juárez, I., Solís, Ó., Martínez‐Téllez, R. I., Camacho‐Abrego, I., Masliah, E., Mena, R., & Flores, G. (2010) · Synapse · doi:10.1002/syn.20787 · Cited by 47 · see citing works

Physiological and pathophysiological control of synaptic GluN2B-NMDA receptors by the C-terminal domain of amyloid precursor protein

Pousinha, P., Mouska, X., Raymond, E., Gwizdek, C., Dhib, G., Poupon, G., Zaragosi, L., Giudici, C., Bethus, I., Pacary, E., et al. (2017) · eLife · doi:10.7554/elife.25659 · Cited by 39 · see citing works

Increasing SK2 channel activity impairs associative learning

McKay, B. M., Oh, M. M., Galvez, R., Burgdorf, J. S., Kroes, R. A., Weiss, C., Adelman, J. P., Moskal, J. R., & Disterhoft, J. F. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00025.2012 · Cited by 45 · see citing works

SK2 channel regulation of neuronal excitability, synaptic transmission, and brain rhythmic activity in health and diseases

Sun, J., Liu, Y., Baudry, M., & Bi, X. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2020.118834 · Cited by 45 · see citing works

Disruption of the Ether-à-go-go K+Channel Gene BEC1/KCNH3 Enhances Cognitive Function

Miyake, A., Takahashi, S., Nakamura, Y., Inamura, K., Matsumoto, S., Mochizuki, S., & Katou, M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0901-09.2009 · Cited by 43 · see citing works

Developmental profile of SK2 channel expression and function in CA1 neurons

Ballesteros‐Merino, C., Lin, M. T., Wu, W., Ferrándiz‐Huertas, C., Cabañero, M. J., Watanabe, M., Fukazawa, Y., Shigemoto, R., Maylie, J., Adelman, J. P., et al. (2011) · Hippocampus · doi:10.1002/hipo.20986 · Cited by 43 · see citing works

Role of Calcium-activated Potassium Channels in Atrial Fibrillation Pathophysiology and Therapy

Diness, J. G., Bentzen, B. H., Sørensen, U. S., & Grunnet, M. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000249 · Cited by 42 · see citing works

Trafficking of Intermediate (KCa3.1) and Small (KCa2.x) Conductance, Ca2+‐Activated K+ Channels: a Novel Target for Medicinal Chemistry Efforts?

Balut, C., Hamilton, K. L., & Devor, D. C. (2012) · ChemMedChem · doi:10.1002/cmdc.201200226 · Cited by 41 · see citing works

The Amyloid Precursor Protein C-Terminal Domain Alters CA1 Neuron Firing, Modifying Hippocampus Oscillations and Impairing Spatial Memory Encoding.

Pousinha, P., Mouska, X., Bianchi, D., Temido-Ferreira, M., Rajão-Saraiva, J., Gomes, R., Fernandez, S., Salgueiro-Pereira, A. R., Gandin, C., Raymond, E., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.08.103 · Cited by 29 · see citing works

Increased Small Conductance Calcium-Activated Potassium Type 2 Channel-Mediated Negative Feedback on N-methyl-D-aspartate Receptors Impairs Synaptic Plasticity Following Context-Dependent Sensitization to Morphine

Fakira, A. K., Portugal, G. S., Carusillo, B., Melyan, Z., & Morón, J. A. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.026 · Cited by 41 · see citing works

KCa2 and KCa3 Channels in Learning and Memory Processes, and Neurodegeneration

Kuiper, E. F. E., Nelemans, A., Luiten, P. G. M., Nijholt, I. M., Dolga, A. M., & Eisel, U. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00107 · Cited by 39 · see citing works

Dopamine and Aging: Intersecting Facets

Rollo, C. D. (2008) · Neurochemical Research · doi:10.1007/s11064-008-9858-7 · Cited by 37 · see citing works

Increasing small conductance Ca2+‐activated potassium channel activity reverses ischemia‐induced impairment of long‐term potentiation

Orfila, J. E., Shimizu, K., Garske, A. K., Deng, G., Maylie, J., Traystman, R. J., Quillinan, N., Adelman, J. P., & Herson, P. S. (2014) · European Journal of Neuroscience · doi:10.1111/ejn.12683 · Cited by 37 · see citing works

METAPLASTICITY: NEW INSIGHTS THROUGH ELECTROPHYSIOLOGICAL INVESTIGATIONS

Mockett, B. G., & Hulme, S. R. (2008) · Journal of Integrative Neuroscience · doi:10.1142/s0219635208001782 · Cited by 37 · see citing works

Prefrontal Cortex KCa2 Channels Regulate mGlu5-Dependent Plasticity and Extinction of Alcohol-Seeking Behavior

Cannady, R., McGonigal, J. T., Newsom, R. J., Woodward, J. J., Mulholland, P. J., & Gass, J. T. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.2873-16.2017 · Cited by 35 · see citing works

Neonatal exposure to sevoflurane caused cognitive deficits by dysregulating SK2 channels and GluA2-lacking AMPA receptors in juvenile rat hippocampus

Yu, X., Zhang, F., & Shi, J. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.08.014 · Cited by 34 · see citing works

Modulating fear extinction memory by manipulating SK potassium channels in the infralimbic cortex

Criado‐Marrero, M., Santini, E., & Porter, J. T. (2014) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2014.00096 · Cited by 33 · see citing works

CyPPA, a Positive SK3/SK2 Modulator, Reduces Activity of Dopaminergic Neurons, Inhibits Dopamine Release, and Counteracts Hyperdopaminergic Behaviors Induced by Methylphenidate1

Herrik, K. F., Redrobe, J. P., Holst, D., Hougaard, C. Ø., Sandager‐Nielsen, K., Nielsen, A. N., Ji, H., Holst, N. M., Rasmussen, H. B., Nielsen, E. Ø., et al. (2012) · Frontiers in Pharmacology · doi:10.3389/fphar.2012.00011 · Cited by 33 · see citing works

SK3 Channel Overexpression in Mice Causes Hippocampal Shrinkage Associated with Cognitive Impairments

Martin, S., Lazzarini, M., Dullin, C., Balakrishnan, S., Gomes, F. V., Ninković, M., Hady, A. E., Pardo, L. A., Stühmer, W., & Bel, E. A. D. (2016) · Molecular Neurobiology · doi:10.1007/s12035-015-9680-6 · Cited by 32 · see citing works

Diverse Structural Features of Potassium Channels Characterized by Scorpion Toxins as Molecular Probes

Zhao, Y., Chen, Z., Cao, Z., Li, W., & Wu, Y. (2019) · Molecules · doi:10.3390/molecules24112045 · Cited by 31 · see citing works

Genetics of autosomal recessive non‐syndromic mental retardation: recent advances

Basel‐Vanagaite, L. (2007) · Clinical Genetics · doi:10.1111/j.1399-0004.2007.00881.x · Cited by 30 · see citing works

Ataxias and cerebellar dysfunction: involvement of synaptic plasticity deficits?

Rinaldo, L., & Hansel, C. (2010) · PubMed · Cited by 30 · see citing works

Overexpression of SK2 Channels Enhances Efferent Suppression of Cochlear Responses Without Enhancing Noise Resistance

Maison, S. F., Parker, L. L., Young, L., Adelman, J. P., Zuo, J., & Liberman, M. C. (2007) · Journal of Neurophysiology · doi:10.1152/jn.01183.2006 · Cited by 29 · see citing works

Infection‐induced endothelial amyloids impair memory

Balczon, R., Pittet, J., Wagener, B. M., Moser, S. A., Voth, S. B., Vorhees, C. V., Williams, M. T., Bridges, J. P., Alvarez, D. F., Koloteva, A., et al. (2019) · The FASEB Journal · doi:10.1096/fj.201900322r · Cited by 27 · see citing works

A Single Prior Injection of Methamphetamine Enhances Methamphetamine Self-Administration (SA) and Blocks SA-Induced Changes in DNA Methylation and mRNA Expression of Potassium Channels in the Rat Nucleus Accumbens

Jayanthi, S., Torres, O. V., Ladenheim, B., & Cadet, J. L. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-01830-3 · Cited by 29 · see citing works

Two Conserved Arginine Residues from the SK3 Potassium Channel Outer Vestibule Control Selectivity of Recognition by Scorpion Toxins

Feng, J. Q., Hu, Y., Yi, H., Yin, S., Han, S. H., Hu, J., Chen, Z., Yang, W., Cao, Z., WAARD, M. M. D., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.433888 · Cited by 28 · see citing works

Selective cognitive deficits and reduced hippocampal brain-derived neurotrophic factor mRNA expression in small-conductance calcium-activated K+ channel deficient mice

Jacobsen, J. P. R., Redrobe, J. P., Hansen, H. H., Petersen, S., Bond, C. T., Adelman, J. P., Mikkelsen, J. D., & Mirza, N. R. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.05.062 · Cited by 27 · see citing works

Early derailment of firing properties in CA1 pyramidal cells of the ventral hippocampus in an Alzheimer's disease mouse model

Spoleti, E., Krashia, P., Barbera, L. L., Nobili, A., Lupaşcu, C. A., Giacalone, E., Keller, F., Migliore, M., Renzi, M., & D’Amelio, M. (2021) · Experimental Neurology · doi:10.1016/j.expneurol.2021.113969 · Cited by 28 · see citing works

Channelopathy of small- and intermediate-conductance Ca2+-activated K+ channels

Nam, Y., Downey, M., Rahman, M. A., Cui, M., & Zhang, M. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00935-1 · Cited by 28 · see citing works

Small Conductance Ca2+-Activated K+Channels Modulate Synaptic Plasticity and Memory Encoding

Stackman, R. W., Hammond, R., Linardatos, E., Gerlach, A. C., Maylie, J., Adelman, J. P., & Tzounopoulos, T. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-23-10163.2002 · Cited by 275 · see citing works

Contextual memory deficits observed in mice overexpressing small conductance Ca2+-activated K+ type 2 (KCa2.2, SK2) channels are caused by an encoding deficitPreprint

Stackman, R. W., Bond, C. T., & Adelman, J. P. (2008) · Learning & Memory · doi:10.1101/lm.906808 · Cited by 20 · see citing works

The small conductance Ca2+-activated K+ channel activator GW542573X impairs hippocampal memory in C57BL/6J mice

Rice, C. A., & Stackman, R. W. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.109960 · Cited by 4 · see citing works

Small Conductance Ca2+-Activated K+ Channels as Targets of CNS Drug Development

Blank, T., Nijholt, I. M., Kye, M. J., & Spiess, J. (2004) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1568007043337472 · Cited by 78 · see citing works

Cellular/Molecular Small Conductance Ca 2 �-Activated K � Channel Knock-Out Mice Reveal the Identity of Calcium-Dependent Afterhyperpolarization Currents

Bond, C. T., Herson, P. S., Strassmaier, T., Hammond, R., Stackman, R. W., Maylie, J., & Adelman, J. P. (2013)