Cited by 148Neurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology ResearchNeural and Behavioral Psychology Studies

Place conditioning with dopamine D1 and D2 agonists injected peripherally or into nucleus accumbens

White, Norman M., Packard, Mark G., Hiroi, Noboru·1991·Psychopharmacology

Abstract

The conditioned place preference technique was used to assess the affective properties of the direct dopamine D1 agonist, SKF38393, and the direct D2 agonist, LY171555 (quinpirole). A three compartment apparatus was used: the animals' pre-experimental preference for the two choice compartments was equal and, within each experimental group, half the rats received drug pairings in each choice compartment. Intraperitoneal injections of SKF38393 produced conditioned place aversions at all doses tested (1.0-4.0 mg/kg); LY171555 produced weak conditioned place preferences at 1.0 and 2.0 mg/kg, but no reliable effect at 4.0 mg/kg. Bilateral intra-accumbens microinjections of SKF38393 produced strong preferences at all doses tested (0.5-2.0 micrograms/side); LY171555 produced strong preferences at two doses (0.5 and 1.0 micrograms/side) and no effect at a third dose (2.0 micrograms/side). These results suggest that activation of either D1 or D2 receptors in the nucleus accumbens can produce reward, and that D1 receptors (and possibly also D2 receptors) located elsewhere in the brain or in the periphery may mediate aversive effects.

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Crossref · 10.1007/bf02244216

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Authors
White, N. M., Packard, M. G., & Hiroi, N.
Affiliations
McGill University (CA)
Venue
Psychopharmacology
Published
1991-02
Volume
103
Issue
2
Pages
271-276
ISSN
  • 0033-3158 (ISSN-L)
  • 1432-2072
OpenAlex
W1972281490
Cited by
148
References
38
Citations by year
2026: 1 · 2025: 3 · 2022: 8 · 2021: 5 · 2020: 3 · 2019: 1 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 6
FWCI
3.01
Type
journal article
Language
en
Open access
closed
Locations
  • Psychopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
conditioned place preference, conditioned place aversion, dopamine D1 receptor, dopamine D2 receptor, SKF 38393, quinpirole, nucleus accumbens, intracerebral microinjection, intraperitoneal injection, reward, aversive effects
MeSH terms
Amphetamine, Animals, Conditioning, Operant, Dose-Response Relationship, Drug, Ergolines, Injections, Male, Nucleus Accumbens, Receptors, Dopamine, Stereotaxic Techniques, Dopamine Agents, 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine, Receptors, Dopamine D1, Receptors, Dopamine D2, Quinpirole, Rats

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