The DOI matches its Crossref record; 8 of the 9 references it cites were found in a registry or an index.
The Phosphoinositide 3-Kinase Pathway
Abstract
Phosphorylated lipids are produced at cellular membranes during signaling events and contribute to the recruitment and activation of various signaling components. The role of phosphoinositide 3-kinase (PI3K), which catalyzes the production of phosphatidylinositol-3,4,5-trisphosphate, in cell survival pathways; the regulation of gene expression and cell metabolism; and cytoskeletal rearrangements are highlighted. The PI3K pathway is implicated in human diseases including diabetes and cancer, and understanding the intricacies of this pathway may provide new avenues for therapuetic intervention.
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“Activation of phosphoinositide-3-kinase (PI3K) by ligation of growth factors to their cellular receptors promotes recruitment of Akt to the plasma membrane and its subsequent activation 28.”
From Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes (2010) · cites this paper as [28]
Citations
Cites
Fruman, D. A., Meyers, R. E., & Cantley, L. C. (1998) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.67.1.481 · Cited by 1,382
Self-citationBrunet, A., Datta, S. R., & Greenberg, M. E. (2001) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00211-7 · Cited by 1,208
Lawlor, M. A., & Alessi, D. R. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.16.2903 · Cited by 1,068
Regulation of C. elegans Life-Span by Insulinlike Signaling in the Nervous System
Wolkow, C. A., Kimura, K. D., Lee, M. S., & Ruvkun, G. (2000) · Science · doi:10.1126/science.290.5489.147 · Cited by 681
PTEN: a tumour suppressor that functions as a phospholipid phosphatase
Maehama, T. (1999) · Trends in Cell Biology · doi:10.1016/s0962-8924(99)01519-6 · Cited by 599
Clark, A. S., West, K. A., Streicher, S. A., & Dennis, P. A. (2002) · PubMed · Cited by 589
The lipid phosphatase SHIP2 controls insulin sensitivity
Clément, S., Krause, U., Desmedt, F., Tanti, J., Behrends, J., Pesesse, X., Sasaki, T., Penninger, J. M., Doherty, M., Malaisse, W. J., et al. (2001) · Nature · doi:10.1038/35051094 · Cited by 377
Identification of CISK, a new member of the SGK kinase family that promotes IL-3-dependent survival
Liu, D., Xiao-hong, Y., & Songyang, Z. (2000) · Current Biology · doi:10.1016/s0960-9822(00)00733-8 · Cited by 135
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1 of the 9 references couldn’t be matched to a known paper.
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ROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
Cancer genes and the pathways they control
Vogelstein, B., & Kinzler, K. W. (2004) · Nature Medicine · doi:10.1038/nm1087 · Cited by 4,346
Mitochondrial membrane permeabilization in cell death
Kroemer, G., Galluzzi, L., & Brenner, C. (2007) · Physiological Reviews · doi:10.1152/physrev.00013.2006 · Cited by 3,598
Mechanisms of type-I- and type-II-interferon-mediated signalling
Platanias, L. C. (2005) · Nature reviews. Immunology · doi:10.1038/nri1604 · Cited by 3,631
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Engelman, J. A., Luo, J., & Cantley, L. C. (2006) · Nature Reviews Genetics · doi:10.1038/nrg1879 · Cited by 3,330
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Metadata
- Authors
- Cantley, L. C.
- Affiliations
- Beth Israel Deaconess Medical Center (US)
- Corresponding author
- Cantley, Lewis C.
- ORCID
- Cantley, Lewis C.
- Venue
- Science
- Published
- 2002-05-31
- Volume
- 296
- Issue
- 5573
- Pages
- 1655-1657
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2070732456
- Cited by
- 5,621
- References
- 9
- Citations by year
- 2026: 87 · 2025: 137 · 2024: 134 · 2023: 182 · 2022: 200 · 2021: 203 · 2020: 216 · 2019: 215 · 2018: 232 · 2017: 276 · 2016: 243 · 2015: 297 · 2014: 292 · 2013: 306 · 2012: 325
- FWCI
- 76.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM041890)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- phosphatidylinositol 3-kinase, PI3K signaling, phosphatidylinositol 3,4,5-trisphosphate, cell survival signaling, gene expression regulation, cellular metabolism, cytoskeletal rearrangement, diabetes mellitus, cancer, therapeutic target
- MeSH terms
- Animals, Cell Membrane, Cell Physiological Phenomena, Diabetes Mellitus, Type 2, Humans, Models, Biological, Neoplasms, Phosphorylation, Protein Kinases, Proto-Oncogene Proteins, Signal Transduction, Protein Serine-Threonine Kinases, Phosphatidylinositol Phosphates, Phosphatidylinositol 4,5-Diphosphate, Phosphatidylinositol 3-Kinases, Proto-Oncogene Proteins c-akt, 3-Phosphoinositide-Dependent Protein Kinases
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