The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Promoter Region of the Human Harvey ras Proto-Oncogene: Similarity to the EGF Receptor Proto-Oncogene Promoter
Abstract
Regulation of transcription of members of the ras gene family undoubtably plays an important role in controlling cellular growth. Examination of this level of regulation requires identification of the promoter regions of the ras proto-oncogenes. Four major transcriptional start sites were detected in the human Harvey ras 1 proto-oncogene. The promoter region contains neither a TATA box nor a CAAT box in their characteristic upstream positions, has an extremely high G+C content (80 percent), and contains multiple GC boxes including seven CCGCCC repeats and three repeats of the inverted complement, GGGCGG. This region has strong promoter activity when placed upstream from the chloramphenicol acetyl transferase gene and transfected into monkey CV1 cells. In these ways the Harvey ras 1 proto-oncogene promoter resembles the promoter of the gene encoding the epidermal growth factor (EGF) receptor. The similarity between the two proto-oncogene promoters may be relevant to the mechanism by which the expression of such "growth control" genes is regulated.
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Cites
Mechanism of activation of a human oncogene
Tabin, C. J., Bradley, S. M., Bargmann, C. I., Weinberg, R. A., Papageorge, A. G., Scolnick, E. M., Dhar, R., Lowy, D. R., & Chang, E. H. (1982) · Nature · doi:10.1038/300143a0 · Cited by 1,393
In vivo sequence requirements of the SV40 early promoter region
Benoist, C., & Chambon, P. (1981) · Nature · doi:10.1038/290304a0 · Cited by 1,074
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Basler, K., Oesch, B., Scott, M., Westaway, D., Wälchli, M., Groth, D. F., McKinley, M. P., Prusiner, S. B., & Weissmann, C. (1986) · Cell · doi:10.1016/0092-8674(86)90662-8 · Cited by 835
c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I.
Fujii, M., Sassone-Corsi, P., & Verma, I. M. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.22.8526 · Cited by 351
Itoh, H., Toyama, R., Kozasa, T., Tsukamoto, T., Matsuoka, M., & Kaziro, Y. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)68692-2 · Cited by 271
Abbott, C. A., McCaughan, G. W., Baker, E., & Sutherland, G. R. (1994) · Immunogenetics · doi:10.1007/bf01246674 · Cited by 177
Metadata
- Authors
- Ishii, S., Merlino, G. T., & Pastan, I.
- Venue
- Science
- Published
- 1985-12-20
- Volume
- 230
- Issue
- 4732
- Pages
- 1378-1381
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2016167564
- Cited by
- 219
- References
- 2
- FWCI
- 10.80
- Type
- journal article
- Language
- en
- Open access
- closed
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- Ishii, S., Merlino, G. T., & Pastan, I. (1985). Promoter Region of the Human Harvey ras Proto-Oncogene: Similarity to the EGF Receptor Proto-Oncogene Promoter. Science. https://doi.org/10.1126/science.2999983
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