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IgG2a restriction of murine antibodies elicited by viral infections.
Open accessAbstract
The isotypic distribution of IgG antibodies was determined in the serum of mice after infection with a panel of RNA and DNA viruses representative of 11 different genera. The antiviral response induced by all these viruses showed a striking preponderance of the IgG2a subclass whatever the strain of mice tested or the time elapsed after infection. Together with the predominance of IgG1 in antiprotein and of IgG3 in anticarbohydrate response, this IgG2a restriction of antiviral antibodies strongly suggests the existence of highly specific mechanisms for the regulation of individual subclasses in the mouse.
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Citations
Cited by
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692
Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production
Snapper, C. M., & Paul, W. E. (1987) · Science · doi:10.1126/science.3107127 · Cited by 1,920
Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells
Stevens, T. L., Bossie, A., Sanders, V. M., Fernandez-Botran, R., Coffman, R. L., Mosmann, T. R., & Vitetta, E. S. (1988) · Nature · doi:10.1038/334255a0 · Cited by 933
The need for IgG2c specific antiserum when isotyping antibodies from C57BL/6 and NOD mice
Martin, R. M., Brady, J. L., & Lew, A. M. (1998) · Journal of Immunological Methods · doi:10.1016/s0022-1759(98)00015-5 · Cited by 330
Biological sex affects vaccine efficacy and protection against influenza in mice
Fink, A. L., Engle, K., Ursin, R. L., Tang, W.-Y., & Klein, S. L. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805268115 · Cited by 253
Metadata
- Authors
- Coutelier, J. P., van der Logt, J. T., Heessen, F. W., Warnier, G., & Van Snick, J.
- Venue
- The Journal of experimental medicine
- Publisher
- Rockefeller University Press
- Published
- 1987-01-01
- Volume
- 165
- Issue
- 1
- Pages
- 64-69
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2139605631
- Cited by
- 428
- References
- 0
- FWCI
- 8.23
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Coutelier, J. P., van der Logt, J. T., Heessen, F. W., Warnier, G., & Van Snick, J. (1987). IgG2a restriction of murine antibodies elicited by viral infections. The Journal of experimental medicine. https://doi.org/10.1084/jem.165.1.64
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
