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Isolation of T-Cell Tropic HTLV-III-Like Retrovirus from Macaques

Daniel, M. D., Letvin, N. L., King, N. W., Kannagi, M., Sehgal, P. K., Hunt, R. D., Kanki, P. J., Essex, M., Desrosiers, R. C.·1985·Science

Abstract

The isolation of a T-cell tropic retrovirus from three immunodeficient macaques and one macaque with lymphoma is described. The morphology, growth characteristics, and antigenic properties of this virus indicate that it is related to the causative agent of acquired immune deficiency syndrome in humans (HTLV-III or LAV). This virus is referred to as simian T-lymphotropic virus type III (STLV-III) of macaques. The existence of a cytopathic, T-cell tropic virus resembling HTLV-III in monkeys may facilitate study of disease induction and vaccine development in an animal model.

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Metadata

Authors
Daniel, M. D., Letvin, N. L., King, N. W., Kannagi, M., Sehgal, P. K., Hunt, R. D., Kanki, P. J., Essex, M., & Desrosiers, R. C.
Venue
Science
Published
1985-06-07
Volume
228
Issue
4704
Pages
1201-1204
ISSN
  • 0036-8075 (ISSN-L)
  • 1095-9203
OpenAlex
W1987888541
Cited by
920
References
0
FWCI
12.19
Type
journal article
Language
en
Open access
closed

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CoChat. (2026). Citation check: Isolation of T-Cell Tropic HTLV-III-Like Retrovirus from Macaques. https://app.cochat.ai/papers/10.1126/science.3159089
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Daniel, M. D., Letvin, N. L., King, N. W., Kannagi, M., Sehgal, P. K., Hunt, R. D., Kanki, P. J., Essex, M., & Desrosiers, R. C. (1985). Isolation of T-Cell Tropic HTLV-III-Like Retrovirus from Macaques. Science. https://doi.org/10.1126/science.3159089

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.