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Mutagenic Activity of Quercetin and Related Compounds
Abstract
The mutagenic activities of several flavonoids and flavonoid metabolites were examined by means of Salmonella typhimurium mutants that reveal base-pair substitution and frameshift mutagens. Of the compounds tested (naringin, rutin, neohesperetin, hesperetin, dihydroquercetin, quercetin, quercetin pentaacetate, permethylquercetin, m -hydroxyphenylacetic acid, and m , p -dihydroxyphenylacetic acid), only quercetin was mutagenic without microsomal activation. With activation, however, the mutagenic activity of quercetin was increased significantly and that of quercetin pentaacetate was revealed. The health implications of these findings and aspects of flavonoid structural requirements for mutagenic activity are discussed.
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Cited by
Middleton, E., Kandaswami, C., & Theoharides, T. C. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01472-8 · Cited by 4,882
Review of the biology of quercetin and related bioflavonoids
Formica, J. V., & Regelson, W. (1995) · Food and Chemical Toxicology · doi:10.1016/0278-6915(95)00077-1 · Cited by 1,765
Hertog, M. G. L., Hollman, P. C. H., Katan, M. B., & Kromhout, D. (1993) · Nutrition and Cancer · doi:10.1080/01635589309514267 · Cited by 1,216
Identifying Environmental Chemicals Causing Mutations and Cancer
Ames, B. N. (1979) · Science · doi:10.1126/science.373122 · Cited by 586
The effect of quercetin on cell cycle progression and growth of human gastric cancer cells
Yoshida, M., Sakai, T., Hosokawa, N., Marui, N., Matsumoto, K., Fujioka, A., Nishino, H., & Aoike, A. (1990) · FEBS Letters · doi:10.1016/0014-5793(90)80053-l · Cited by 317
Metadata
- Authors
- Bjeldanes, L. F., & Chang, G. W.
- Venue
- Science
- Published
- 1977-08-05
- Volume
- 197
- Issue
- 4303
- Pages
- 577-578
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2038435336
- Cited by
- 348
- References
- 0
- FWCI
- 8.24
- Type
- journal article
- Language
- en
- Open access
- closed
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